NDLI: Data-Driven Optimization of Brain SPECT Processing for Voxel-Based Statistical Analysis

Content Provider	IEEE Xplore Digital Library
Author	Barnden, L.R. Behin-Ain, S.
Copyright Year	1963
Abstract	Brain SPECT processing methods were assessed by reprocessing a SPECT study of aging in brain perfusion that revealed both localized preservation and losses. Each analysis was characterized by the Z statistic for linear regression of SPECT versus age in six locations: three with preservation, three with accelerated loss. We investigated the effect of reconstruction (FBP or OSEM), scatter subtraction (SS), removal of facial and scalp activity, global scaling to the whole-brain and cerebellum, and spatial normalization with both SPM99 and SPM2. Facial activity was edited manually. Scalp activity was removed using a generic weighting image after an initial affine spatial normalization. Global scaling was performed with SPMs "proportional scaling," or a scalp-free mean applied either as a nuisance variable (ANCOVA) or to prescale the images. Stronger statistics resulted from FBP with SS, removal of facial and scalp activity and nonlinear spatial normalization. Proportional scaling was biased and yielded very strong SPECT preservation but no significant SPECT loss. The scalp-free mean as a nuisance variable yielded both significant SPECT preservation and losses, but statistics were strongest when it was used to prescale the images. These scaling effects arose from age-dependence in the global means. Scaling to the cerebellum mean yielded weaker results than the whole brain. SPM99 yielded similar results to SPM2. Scaling of brain SPECT images should utilize a scalp-free mean and age should be included as a covariate in regional SPECT analysis
Sponsorship	IEEE Nuclear and Plasma Sciences Society Computer Applications in Nuclear and Plasma Sciences (CANPS) Lawrence Berkeley Lab. Lawrence Livermore Nat. Lab. APS College of William and Mary Continuous Electron Beam Accelerator Facility NASA Defence Nuclear Agency Sandia National Laboratories Jet Propulsion Laboratory Brookhaven Nat. Lab. Lawrence Livermore Nat. Lab IEEE/NPPS Radiat. Effects Committee Defence Nuclear Agency/DoD Sandia National Laboratories/DOE Jet Propulsion Laboratory/NASA Phillips Lab./DoD
Starting Page	2822
Ending Page	2826
Page Count	5
File Size	476342
File Format	PDF
ISSN	00189499
Volume Number	53
Issue Number	5
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-10-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Statistical analysis Scalp Statistics Hospitals Australia Image reconstruction Atrophy Linear regression Accelerated aging Scattering voxel-based analysis Brain SPECT optimization
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Electrical and Electronic Engineering Nuclear Energy and Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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