NDLI: A New Method for Hot-Spot Quantification of Hybrid SPECT/CT Cardiac Images: Methodology and Preliminary Phantom Validation

Content Provider	IEEE Xplore Digital Library
Author	Yi-Hwa Liu Fernando, G.P. Sinusas, A.J.
Copyright Year	1963
Abstract	We present a new method for quantification of "hot-spot" cardiac single-photon-emission computerized tomography (SPECT) and preliminary phantom validation. Our quantification method was developed based on the circumferential count profiles of reference perfusion and focal hot-spot SPECT images. Normal hot-spot limit was estimated from the circumferential count profiles using the Bayes estimator and joint entropy maximization. Focal hot-spot uptake in the myocardium was calculated based on the normal hot-spot limit. The quantification method was validated using a cardiac phantom filled with ²⁰¹Tl solution simulating normal myocardial perfusion. A hot-spot insert was filled with a series of different concentrations (5 muCi/mL-25 muCi/mL) of ⁹⁹mTc solution to simulate a wide range of myocardial focal hot-spot uptake. A spherical point source filled with a known dose of ^99mTc solution was used as an external reference. No extra cardiac and background activities were simulated. Dual-isotope images were acquired simultaneously using a hybrid SPECT/CT imaging system. Acquired images were reconstructed with and without CT-based attenuation correction and were quantified using the new quantification method. Correlation between SPECT quantified activities and actual hot-spot activities measured in a dose calibrator was fair without CT attenuation correction (r=0.78) and was improved with CT attenuation correction (r=0.84 and 0.997). Hot-spot activity was considerably underestimated in the absence of attenuation correction (Mean error=-146 muCi). Accuracy of the quantified hot-spot activity was markedly improved when the attenuation correction was employed (Mean error=-50 muCi and -10 muCi). In conclusion, our method for assessment of absolute hot-spot activity with incorporation of the CT-based attenuation correction may allow for accurate quantification of myocardial hot-spot uptake
Sponsorship	IEEE Nuclear and Plasma Sciences Society Computer Applications in Nuclear and Plasma Sciences (CANPS) Lawrence Berkeley Lab. Lawrence Livermore Nat. Lab. APS College of William and Mary Continuous Electron Beam Accelerator Facility NASA Defence Nuclear Agency Sandia National Laboratories Jet Propulsion Laboratory Brookhaven Nat. Lab. Lawrence Livermore Nat. Lab IEEE/NPPS Radiat. Effects Committee Defence Nuclear Agency/DoD Sandia National Laboratories/DOE Jet Propulsion Laboratory/NASA Phillips Lab./DoD
Starting Page	2814
Ending Page	2821
Page Count	8
File Size	1282265
File Format	PDF
ISSN	00189499
Volume Number	53
Issue Number	5
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-10-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Computed tomography Imaging phantoms Myocardium Cardiology Biomedical imaging Entropy Image reconstruction Attenuation measurement Visualization Application software single-photon-emission computerized tomography (SPECT) Computerized tomography (CT) hot-spot phantom quantification
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Electrical and Electronic Engineering Nuclear Energy and Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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