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| Content Provider | Directory of Open Access Journals (DOAJ) |
|---|---|
| Author | Abbey Lightfoot Helen M. McGettrick Asif J. Iqbal |
| Abstract | Leukocyte recruitment to the site of injury is a crucial event in the regulation of an inflammatory response. Tight regulation of interactions between the endothelium and circulating leukocytes is necessary to ensure a protective response to injury does not result in inflammatory disease. Rising interest in the broad immunoregulatory roles displayed by members of the glycan-binding galectin family suggests that these proteins could be an attractive target for therapeutic intervention, since their expression is significantly altered in disease. The focus of this review is to summarize current knowledge on the role of galectins in leukocyte trafficking during inflammation and the clinical approaches being taken to target these interactions for treatment of inflammatory disease. |
| e-ISSN | 16643224 |
| DOI | 10.3389/fimmu.2021.687711 |
| Journal | Frontiers in Immunology |
| Volume Number | 12 |
| Language | English |
| Publisher | Frontiers Media S.A. |
| Publisher Date | 2021-06-01 |
| Publisher Place | Switzerland |
| Access Restriction | Open |
| Subject Keyword | Immunologic Diseases. Allergy Galectins Leukocyte Trafficking Glycan-binding Protein Endothelial Cell Vascular Biology |
| Content Type | Text |
| Resource Type | Article |
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