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| Content Provider | Directory of Open Access Journals (DOAJ) |
|---|---|
| Author | Elise Gradhand Steffen Kunzmann Stefanie Y. Zimmermann Shahrzad Bakhtiar Milica Miladinovic Boris Wittekindt Sebastian Fischer Thomas Klingebiel Rolf Schlösser Thomas Lehrnbecher |
| Abstract | Chronic granulomatous disease (CGD) is a primary immunodeficiency, which is diagnosed in most patients between one and three years of age. Here we report on a boy who presented at birth with extensive skin lesions and lymphadenopathy which were caused by CGD. An analysis of the literature revealed 24 patients with CGD who became symptomatic during the first six weeks of life. Although pulmonary complications and skin lesions due to infection were the leading symptoms, clinical features were extremely heterogenous. As follow-up was not well specified in most patients, the long-term prognosis of children with very early onset of CGD remains unknown. |
| e-ISSN | 16643224 |
| DOI | 10.3389/fimmu.2021.663883 |
| Journal | Frontiers in Immunology |
| Volume Number | 12 |
| Language | English |
| Publisher | Frontiers Media S.A. |
| Publisher Date | 2021-03-01 |
| Publisher Place | Switzerland |
| Access Restriction | Open |
| Subject Keyword | Immunologic Diseases. Allergy Chronic Granulomatous Disease Neonate Early Onset Symptoms Outcome |
| Content Type | Text |
| Resource Type | Article |
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