NDLI: Effects of Chondroadherin on Cartilage Nanostructure and Biomechanics via Murine Model

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Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments

Determination of Layer and Region Specific Mechanical Properties of Intraluminal Thrombus (ILT): The Importance of Biaxial Tensile Testing

Region-Specific Medial Fiber Micro-Architecture in the Longitudinal-Radial and Circumferential-Radial Planes of Ascending Thoracic Aortic Aneurysm Among Bicuspid and Tricuspid Aortic Valve Patients

Abdominal Aortic Aneurysm Rupture Risk Assessment Exploiting Dynamic (4D) CT Based Wall Motion Data and Finite Element Analysis

Progression of Abdominal Aortic Aneurysm: Effect of Lagrangian Transport and Hemodynamic Parameters

Wall Shear Stress and Intraluminal Thrombus Changes in Abdominal Aortic Aneurysms: Study With Longitudinal Patients

AAA Rupture Risk Assessment in the Clinic: Wall Stress or Geometric Characterization?

Necking and Failure of Constrained Contractile 3D Microtissues: Role of Geometry and Stiffness

Effect of Boundary Stiffness on Contractility Profile of Valvular Interstitial Cells

Versatility of a Collagen Adaptation Model That Includes Strain-Dependent Degeneration and Cell Traction

Temperature Control During Fibrillogenesis Allows for Improved Magnetic Alignment of Collagen

Electrochemical Compaction of the Collagen: Effects on Matrix Mechanics and MSC Response

Investigating the Effect of Mechanical Stimuli on Omental Mesothelium Differentiation

Distributed Live Muscle Actuators Controlled by Optical Stimuli

Local Anisotropic Mechanical Behavior of Human Carotid Atherosclerotic Plaques: Characterization Using Indentation Test and Inverse Finite Element Analysis

CFD and VH-IVUS Biomechanical Analysis of Coronary Artery Disease With One Year Follow-Up

Experimental and Numerical Study of Ascending Aorta Hemodynamics Through 3D Particle Tracking Velocimetry and Computational Fluid Dynamics

Head Rotation Effects on the Flow and Hemodynamics of the Human Carotid Bifurcation

Estimation of Atherosclerotic Plaque Material Properties: A Mixed Method of Strain Imaging and Inverse Finite Element Analysis

Platelet Activity State in Human, Bovine, and Ovine Species Under Constant Shear Stress: A Comparative Study

Role of Hemodynamic Shear Stress Abnormalities in the Early Pathogenesis of Bicuspid Aortic Valve Calcification

Intra-Aneurysmal Flow Complexity Quantification Using Flowlines Geometry

Aneurismal Arteries are Vulnerable to Mechanical Buckling

Effects of Valve Geometry and Tissue Anisotropy on the Radial Stretch and Coaptation Area of Tissue-Engineered Heart Valves

Multi-Phase Blood Flow Modeling in Intracranial Aneurysms Considering Possible Transition to Turbulence

Spline Based Microstructural Mapping for Soft Biological Tissues: Application to Aortic Valves

Validation of Cerebral Blood Flow in Intracranial Aneurysms: CFD Versus 7 Tesla 4D PC-MRI

Geometrical and Morphological Assessment of Human Endarterectomy Specimens In Vitro

Aortic Valve Sinus Vorticity Dynamics and the Potential Role of Coronary Flow

Combined Analysis of Pathology and Hemodynamics of Human Unruptured Cerebral Aneurysm With Thin-Walled Region

Aging Endothelial Cells Exhibit Decreased Response to Atheroprotective Shear Stress

Ascending Thoracic Aorta Exhibits Anisotropic Failure Behavior in Shear Lap Testing

Hemodynamics of Abdominal Aortic Aneurysm and its Clinical Relevance in Patients With Infrarenal Stent-Graft Implantation

The Chink in the Armor of the Mitral Valve Annulus: The Irregular Distribution of Mechanical Properties

Advanced Human Coronary Plaque Wall Thickness Correlates Positively With Flow Shear Stress and Negatively With Plaque Wall Stress: An IVUS-Based FSI Study

Reduction in Mechanical Wall Strain Precedes Intimal Hyperplasia Formation in a Murine Model of Arterial Occlusive Disease

Sudden Death in Coronary Artery Disease are Associated With High 3D Critical Plaque Wall Stress: A 3D Multi-Patient FSI Study Based on Ex Vivo MRI of Coronary Plaques

Numerical Modelling of the Mass Transport of Blood-Borne Species in Cerebral Aneurysms of the Basilar Artery

Small Scale Flow Structure Evolution During Mechanical Heart Valve Closure

Optimal Constitutive Parameters and Subject Specific Variability: An Application to the Aortic Sinuses

Experimental Determination of the Mechanical and Biological Properties of Carotid Artery Plaques

Innovative Design and Manufacturing Techniques for Patient Specific Abdominal Aortic Aneurysm Flexible Benchtop Models

A Novel Device for the Microindentation of Soft Biomaterials With Application to Aortic Valve Leaflets

Identification of the Toughness Properties of Mitral Valve Leaflets

Treatment With Non-Nucleoside Reverse Transcriptase Inhibitor Efavirenz Leads to Increase of Carotid Intima-Media Thickness in Mice

Development of a 1D Model for Assessing the Aortic Root Pressure Drop With Viscosity and Compliance

Investigation of the Fatigue Properties of Mitral Valve Leaflets

AView: A Clinical Tool for Hemodynamic and Morphological Analysis of Intracranial Aneurysms

Interlayer Micromechanics of Semilunar Heart Valve Leaflets

Uvula Dynamic Characteristics

An Investigation Into the Molecular Pathways of Airway Smooth Muscle Relaxation

In Vitro Evaluation of Shear-Induced Platelet Activation in the MicroMed DeBakey Ventricular Assist Device With Antiplatelet Therapy

The Impact of Tissue Viscoelasticity on the Flow Dynamics of an Anti-HIV Microbicidal Gel: Numerical Simulations

Obstetrician Hand Pressures During Mock Deliveries

Experimental Study of Hemodynamics in the Circle of Willis

Computational Fluid Dynamics Simulation of Airflow Alteration in the Trachea Before and After Vascular Ring Surgery

Computational Fluid Dynamics Analysis of Early Embryonic Aortic Arch-Ligation

Rheology Effects on Mucus Plug Rupture

Phosphotungstic Acid Diffusion in Porcine Ocular Tissue for MicroCT Shape Reconstruction

The Impact of Boundary Conditions on Surface Curvature Measurements of Polypropylene Mesh in Response to Uniaxial Loading

Effects of Channel Size and Shear Rate on Platelet Margination

Whole Eye Model for Estimating Accommodation-Induced Strains in the Trabecular Meshwork

Imaging-Based Multiscale Models of the Respiratory System That Account for Regional Heterogeneity in Health and Disease

Age Dependent and Anisotropic Material Properties of Immature Porcine Sclera

A Continuum Material Model for Urogynecogical Meshes

Characterizing Swelling Pressure and Hydration Relationship for Porcine Corneal Stroma

Nycthemeral Rhythm of the Frequency and Biomechanical Energy of High Frequency Intraocular Pressure Fluctuations

Calcium Regulation in Lymphatic Endothelial Cells Under Flow

Phenomenology of Hemolysis in Turbulent Flows

Using Journal Clubs to Teach Biomechanics: A Two-Year Review

RescuShell: A Biomechanical Design Epistemic Game for First-Year Engineering Education and Potentially Increased Retention of Women

An Interdisciplinary Capstone Experience Involving Engineering and Business Students and a Manufacturing Rotation

WPI iCREATE: Graduate Training in Innovative Translation

Problem Based Learning Biomechanics Lab: Running Shoes: Friend or Foe

WPI iCREATE: Innovation and Translation in Senior Level Biomedical Engineering Course

A New Interdisciplinary PhD Program in Bioinnovation at Tulane University

Supplementing Basic Graduate Level Courses With Conference-Based Research Communication Experiences

The Role of Motion Analysis in Biomedical Engineering Education and Interdisciplinary Research

Research-Focused Undergraduate Laboratory Exercises in Biomechanics

Developing Entrepreneurial Thinking in University of Kansas Bioengineering Students

An Engineering Approach Investigating the Uptake and Phytotoxicity of One Type of Engineered Nanoparticle (CdSe/ZnS Quantum Dots) by Solanum Lycopersicum

Effect of Temperature and Cryoprotectant Solutes on Water Permeability of SF21 Cell Membrane

Evaluation of Temperature Transients at Various Body Temperature Measuring Sites Using a Fast Response Thermistor Bead Sensor

Effect of Tumor Heterogeneity on Interstitial Pressure and Fluid Flow

Effect of Vascular Network on Conventional Cryosurgery and Nano-Cryosurgery

Reducing the Osmotic Damage of RBCs During the Removal of CPAs From Cryopreserved Blood by the Dilution-Concentration Method: Extended Dilution Region

Assessment of an Exponential Scaling Relationship for Backflow Length in Brain Tissue

Increasing the Removal Efficiency of CPAs by the Dilution-Concentration Method: Adaptive Optimization of Diluent Flow Rates

Synthesis of Poly (L-Lactic Acid) Scaffolds Under Controlled Freezing Conditions

Testing Image Processing Algorithms for Melanoma Detection

Effect of CPA Transmembrane Flux on Cell Volume Change During Freezing and its Application in Biopreservation

Surface Modified Nitinol Stents Release Metal Ions in Blood

Theoretical Simulation of Temperature Elevations in Tumors Using Monte Carlo Method and Comparison to Experimental Measurements During Laser Photothermal Therapy

Nonlinear Derating of High-Intensity Therapeutic Ultrasound Beams Using Gaussian Modal Sums

Simulation of Velocity and Concentration Fields in Artificial Kidneys

Theoretical Predictions of Body Tissue and Blood Temperature During Cold Water Immersion Using a Whole Body Model

Numerical Study of Temperature Profile During ADV Enhanced HIFU Thermal Ablation of Tumor

Effect of Superparamagnetism Nanoparticles on Microwave Rewarming Process of Cryopreserved Tissues

Numerical Study of the Influence of Water Evaporation on Radiofrequency Ablation

A Virtual Test Bench to Study Transport Phenomena in 3D Porous Scaffolds Using Lattice Boltzmann Simulations

Skin Perfusion, Arterial and Venous Blood Flow, and Soft Tissue Thickness in Relation to Pressure Ulcers

A 3D Microfluidic Tumor Construct to Determine Transport and Photothermal Properties of Single Walled Nanohorns

Tissue Hydration Influences Bursting Pressure of Fused Arteries

Simulation and Analysis of a Flow Profile and Reaction Rate Within a 3D Microfluidic Cell Culture Array

Characterization of Microscale Particles Using a Microfluidic Flow Cytometer Equipped With a Multi-Plex Photon Counter

The Feasibility of Using Millimeter Wave Heating for Non-Invasive Measurement of Skin Blood Flow in Humans

Artificial Swimmer Powered by Cardiomyocytes

A Novel Bio-Microelectromechanical System for In Vivo Diagnostic Monitoring of Fracture Healing

Enhancement of Prediction for Hip Fractures Using Stochastic Assessment of Bone Mineral Density Distribution From DXA Images

Systemic PTH Release During Exercise Enhances Trabecular Bone Architecture

3D In Vivo Bone Dynamic Imaging of PTH’s Anabolic Action

Spaceflight Related Changes in Structure and Strength of Mouse Trabecular and Cortical Bone From the STS-118 Space Shuttle Mission

Multiscale Experimental and Computational Investigation of Cortical Bone Fracture

Generation of Grade Specific Finite Element Model of Lumbar Spines

Finite Element Predictions of Cartilage Contact Mechanics in Hips With Retroverted Acetabula

Effect of Asymmetry on Finite Element Model of Cervical Spine

Development of a Biomechanical Model Producing Proximal Pedicle Pullout of Long Fusion Spinal Constructs

In Vivo Biomechanics of Thumb Carpometacarpal Joint: A Preliminary Study of Gender Differences

Strength of Materials Based Prediction of Critical Stresses at the Proximal Femur: Validation by Finite Element Analysis

Biaxial Response of Ovine Spinal Cord Dura Mater

Selective Densitometry of the Lumbar Spine

Changes in Endplate Thickness and Apparent Density After Disc Herniation

Changes in Foraminal Geometry With Anterior Decompression Versus Keyhole Foraminotomy in the Cervical Spine: A Biomechanical Investigation

Biomedical Evaluation of Polymerized Biodegradable Cement vs. PMMA Cement in Kyphoplasty for Vertebral Compressive Fractures

Fluid-Structure Interaction Modelling Predicts That Strain Transfer Through Focal Attachments of Osteoblast Cells are the Primary Mediators of Mechanical Stimulation Under Fluid Flow

Characterization of In Vivo Lumbar Range of Motion During Flexion in Healthy Subjects

Dependence of Human Lumbar Vertebral Trabecular Bone (HVTB) Mechanical Anisotropy Ratio on QCT–Based Apparent Density

Simulation of the Whole Human Spine Using Finite Elements: P & H Version Convergence

Effect of Fibers on the Fracture Strength of Bone-Cement Interfaces

Pressure Gradients in the Trabecular Pore Space of Femurs During Physiologic Loading

Development of a Biomechanical Model for Sacroiliac Range of Motion

A Computationally Efficient and Accurate Lumbar Spine Model

Validation of Digital Image Correlation Techniques for Strain Measurement in Biomechanical Test Models

Impact Behavior of Graded Porous Hip Joint

Effects of Freeze-Thaw Cycling on Material Properties of Cancellous Cervine Bone as Characterized by Nanoindentation

Effects of Spine Soft Tissue Stiffening on Biomechanics of Lumbar Spine: A FEA Study

Assessment of the Vascular and Trabecular Microstructures Using Micro Computed Tomography, Vascular Network Perfusion, and Image Registration Techniques

Direct Structured Finite Element Mesh Generation From Three-Dimensional Medical Images

The Complex Shear Modulus of Humpback Whale Blubber

Comparison of Mechanical Variable Identifiers of Brain Injury

Anisotropic Behavior of White Matter in Shear and Implications for Transversely Isotropic Models

Practical Challenges in Collecting Head Impact Biomechanics Data in Real-World Scenarios via a Helmet-Based Accelerometer System

Quantification of Shockwave Transmission Through the Cranium Using an Experimental Model

Comparing In Vivo Head Impact Kinematics From American Football With Laboratory Drop and Linear Impactors

Experimental Determination of Pressure Wave Transmission to the Brain During Head-Neck Blast Tests

Do Infarcts Really Expand or Compact? Relationship Between Changing Material Properties and Apparent Infarct Remodeling

Effect of Thermosensitive Hydrogel Injection on Mechanical Behavior of Porcine Myocardium

Bioengineered SDF-1a Analogue Delivered as an Angiogenic Therapy Significantly Normalizes Elastic and Viscoelastic Material Properties of Infarcted Cardiac Muscle

Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Cellular and Hemodynamic Changes in a Mouse Model

Selective Electrical Stimulation of Adult Cardiomyocyte for Studying Intercellular Mechanical Transmission

Patient-Specific Hemodynamic Simulations in a Group of Patients With Coronary Artery Aneurysms Caused by Kawasaki Disease

A Novel Flow Diverter for Direct Treatment of Cerebral Aneurysms

Patient-Specific Stented Coronary Bifurcations: Numerical Analysis of Near-Wall Quantities and the Bulk Flow

Computational Hemodynamic Assessment of a Novel Modular Anastomotic Valve Device for Improving Hemodialysis Vascular Access Patency

Patient Specific Stent Malapposition in Challenging Anatomy: An FEA Methodology to Understand Numerically the Extent of Malapposition of Latest Generation Stents

A Treatment for Chronic Deep Venous Insufficiency Utilizing Induced Pluripotent Stem Cell Derived Endothelial Cells

The Use of Stentrievers in Acute Ischemic Stroke: Performance Evaluation in a Patient-Specific Vascular Replica

Modal Characteristics of Self-Excited Oscillations in Collapsible Tube With Low Elastic Modulus

Shape Analysis for Automatic and Objective Visualization of Pathological Cardiovascular Remodeling From Cine Cardiac MRI

Investigation of the Spatial Structure of the Microcirculation in a Capillary Bundle From Rat Spinotrapezius Muscle Tissue

Effects of Wall Distensibility on the Numerical Simulation of Arteriovenous Fistulae

The Biomechanical Properties of Arterial Elastin With Glucose Effect

Image Based Flow Computations Without User Generated Meshes

Tensile Strength of the Aorta can be Estimated From Mechanical Parameters Which Depends on Degree of Intramural Collagen Fiber Alignment

Speeding Up Fluid-Structure Interaction Simulation of the Blood Flow in a Flexible Artery Using Sub-Cycling: Stability and Accuracy

Fluid-Structure Interaction Predictions of Ascending Aorta Hemodynamics Under Tricuspid and Bicuspid Aortic Valve Flows

Constitutive Modeling of Biaxial Mechanical Response of Arteries Subjected to Gradual Elastin Degradation

Rheological Study of Collagen Gel With Different Surface Conditions

The Experimental Investigation of Flow Separation Downstream of an Axisymmetric Stenosis in Newtonian and Non-Newtonian Flow Environments

Postnatal Time Course of Arterial Mechanics in a Mouse Model of Pathological Remodeling due to Decreased Elastin Amounts

An Efficient Preconditioner for Linear System Solution in Multi-Domain Modeling of the Circulatory System

Assessment of Aortic Stenosis Severity Using Pressure Drop Coefficient: A Retrospective Study in Humans

Active Stress in the Porcine Renal Artery

Longitudinal Effect of Pressure Drop on the Intima-Media Thickening of the Venous Segment of the Arteriovenous Fistula

3D Computational Fluid-Structure Interaction Model of Canine Heart With Different Patch Materials for Optimal Myocardium Regeneration

Automated Hexahedral Mesh Generation in a Complex Vascular Tree: The Extended Treemesh Method

Cerebrospinal Fluid Dynamics in the Cervical Spine: Importance of Fine Anatomical Structures

Hemodynamic and Structural Implications of Asymmetric Deployment of Transcatheter Aortic Valves: An In Vitro Study

High-Throughput Microtissue Contractility Assay for In Vitro Analysis of Vascular Mechanics

In Vivo Measurements of Blood Transport Patterns and Stasis in the Human Left Ventricle

Predilections of Cardiogenic Embolic Transport to the Cerebral Versus Peripheral Arteries

Mechanical Effects of Myofibril Disarray on Cardiac Function

Experimental Validation of a Computational Algorithm for the Zero Pressure Geometry Derivation of Blood Vessels

Quantitative In Vivo Evaluation of Neointimal Hyperplasia Using High-Resolution Contrast-Enhanced Cone-Beam Computed Tomography

A Feature-Based Morphing Methodology for In-Vivo Strain Assessment in Biological Structures

A Public Repository of Image-Based Computational Models and Patient-Specific Blood Flow Simulation Results

Improved Assessment of Coronary Flow Impairment Using N-13 Ammonia Positron Emission Tomography

Imaging-Based Wave Intensity Analysis: Applications in Congenital Heart Disease

Improving 3D Cine Phase Contrast MRI Aortic Hemodynamics In Vivo Measurements by Means of an Anisotropic Diffusion Filter

Development of Framework to Examine the Focal Association Between Wall Shear Stress and Coronary Artery Disease Progression in the Clinical Setting

Modeling Unstable Brain Aneurysms: MR Molecular Imaging of Myeloperoxidase in Vascular Wall and Correlation With Human Pathology

Retention and Transport of Hydrophobic and Hydrophilic Drug Surrogate Molecules in Coronary Arteries Measured Nondestructively With Photoacoustic Ultrasound

Simulation of the Role of Oscillatory Shear Stress on Mesenchymal Stem Cell Proliferation and Extracellular Matrix Production in Engineered Heart Valve Tissue Formation

Collagen-Hyaluronic Acid Hydrogels Provide Enhanced EMT of Endocardial Cells

Steady Flow Preconditioning of Endothelial Outgrowth Cells on Ex Vivo and In Vivo ePTFE Grafts

Towards a Clinically Applicable Tissue Engineered Vascular Graft

Assessment of Induced Pluripotent Stem Cell-Derived Cardiomyocyte Contractility Using Micropost Arrays

Novel Tissue-Engineered Heart Valve

Finite Element Predictions of Joint Contact Mechanics and Acetabular Curvature in Dysplastic Human Hips

The Effect of Creep on Human Lumbar Intervertebral Disc Impact Mechanics

Comparison of Intervertebral Disc Displacements Measured Under Applied Loading With MRI at 3.0T and 9.4T

The Changing Depth Dependant Properties of Articular Cartilage During Postnatal Development

Effects of Chondroadherin on Cartilage Nanostructure and Biomechanics via Murine Model

Contributions of Proteoglycans to the Biotransport and Electrical Properties of Articular Cartilage: An Experimental Study

Cell Adhesion on a Wavy Surface

Expression of Primary Cilia on Liver Stem and Progenitor Cells: Potential Role for Mechanosensing in Liver Development

Spatial Actin Structure Does Not Correlate With Nuclear Organization

Development of a Biodegradable Regenerative Implant for the Treatment of Long Bone Comminuted Fractures

Engineered Microtissues for Real-Time Characterization of Cardiomyocyte Function

Computational Modeling of Cell Orientation in 3D Micro-Constructs

The Strain Response of Lung Myofibroblasts Cultured on Electrospun Polycaprolactone Nanofibers

Murine Osteochondral Stem Cells Express Collagen Type I More Strongly on PDMS Substrates Than on Tissue Culture Plastic

Hemodynamic Forces Regulate Collagen Deposition in the Embryonic Chicken Outflow Tract

Proliferation of Cells From a Mouse Model of Regeneration

Red Blood Cell Surface Receptor Expression of BCAM/Lu is Regulated by Protein Kinase A Activity

Understanding the Mechanical Properties of Microalgae Using Atomic Force Microscopy

A Study on the Mechanical Properties of Acellular Dermal Matrices and Their Interface Properties After Implantation in an Acute Abdominal Wall Defect in a Primate

Calcium Signaling is a Key Regulator of Mesenchymal Stem Cell Response to Hydrostatic Pressure

Material Composition Gradients and Protein Release for Tracheal Defect Repair

Fluid Dynamic Gauging-Based Assays for High-Throughput Investigation of Cellular Mechanotransduction

Differences in Engineered Cartilage From Human Chondrocytes and Mesenchymal Stem Cells in Pellet and Construct Culture

Augmented and Magnetically-Aligned Type I Collagen-GAG Scaffolds for Cartilage Tissue Engineering

Fabrication of Hybrid Cell-Microbead Constructs Using Laser Direct-Write of Alginate Microbeads and Adherent Breast Cancer Cells

Contrasting the Thrombotic Phenotype of Donor-Matched Endothelial Outgrowth Cells and Endothelial Cells

Cellular Traction Forces Measured With Microposts Made by Hot Embossing of Polystyrene

Trajectory-Based Tissue Engineering for Cartilage Repair: Correlation Between Maturation Rate and Integration Capacity

A Novel Multi-Stimuli Bioreactor for Tissue Engineering Cartilage

In Situ Calcium Signaling of Chondrocytes Under Non-Serum and Serum Culture

Electrospun Hyaluronic Acid Scaffolds Containing Microspheres for Protein Delivery to Support Peripheral Nerve Growth

The Effects of Mechanical and Chemical Stimuli on Mesenchymal Stem Cell Vascular Trans-Differentiation and Paracrine Signaling

Platelet Activity of Coaxial Electrospun Scaffolds for Applications in Cardiovascular Tissue Engineering

In Vitro Biocompatibility of Coaxial Electrospun Scaffolds for Cardiovascular Tissue Engineering

Implementation and Validation of Planar Soft Tissue Structural Constitutive Model

Phototherapy Enhanced Exclusion of Aneurysms From the Cerebral Circulation

Numerical Modeling of the Flow in Cerebral Aneurysms Can Predict Thrombus Deposition Regions Following Vascular Interventions

Flow Diversion in Rabbit Aneurysm Models

Hemodynamics and Natural History Outcome in Unruptured Intracranial Aneurysms: A Prospective Longitudinal Cohort Study

Regularization of Phase-Contrast MRI Velocity Measurements: Initial In Vivo Experience in a Canine Aneurysm Model

Computational Models of Cerebral Aneurysms Using Intravascular Hemodynamic Measurements

Computational Modeling and Analysis of Hemodynamic Effects of Diastolic Heart Dysfunction During the Whole Cardiac Cycle

An Uncoupled Multi-Scale CFD Approach to Cell Motion in the Human Left Coronary Artery: Relation to Plaque Progression

Fractional Flow Reserve Estimation in Coronary Arteries by Forward Geometrical Modeling

Electrical Analog Models to Simulate the Impact of Partial Hepatectomy on Hepatic Hemodynamics

An Automated Simulation Protocol for Exercise Physiology in Fontan Patients Using a Closed-Loop Lumped-Parameter Model

The Influence of Pulmonary Hemodynamics on Right Ventricular Function in Pulmonary Hypertension

Expediting Spinal Cord Stimulation Lead Design With Anatomical Bench Modeling

Cost Optimization of a Multilayer Microchannel Dialyzer

Solid and Fluid Simulations of Vertebral Artery Stenosis Treated With Stents With Different Shapes of Link

Bioabsorbable Cross Pin vs Endobutton for ACL Reconstruction: A Biomechanical Study in Porcine Model

Numerical Investigation of a Novel Microfluidic System and its Application in Achieving Ultra-Fast Cooling/Warming Rates for Cell Vitrification Cryopreservation

Stroke Rehabilitation Enhancement With DVD-Guided Visualization

GPU-Based Algorithm for Fast Computation of Cartilage Contact Patterns During Simulations of Movement

Parameters Influencing Distal Tip Loading of Pacemaker and Defibrillator Leads

Customized Release of Metronidazole From Composite Casted Rings of Poly-Caprolactone/Alginate for Periodontal Drug Delivery

A 3D Motion Phantom for Assessing the Accuracy and Precision of Dynamic Magnetic Resonance Measurement of In Vivo Knee Kinematics

A New Device for an Early Rehabilitation of the Ankle Joint and its Effects on Brain Activation: A NIRS and EEG Study

Development and Preliminary Testing of a Rehabilitation Game to Improve Listening in Background Noise

Development of a Laboratory Model of Aortic Valve Calcification

Design Analysis: Modular Reverse Total Shoulder Prosthetic Failure Without Proximal Bone Support

Macro- and Microscale Analysis of Bearing Surface Damage on Total Shoulder Replacements

Structure and Mechanical Properties of PCL/PG Devices Prepared by Selective Laser Sintering for Drug Delivery Applications

Application of Residence Time Distribution Analysis in Microchannel Hemodialysis Devices

Heparin Leakage by Advective-Diffusive Transport in Central Venous Catheters

Segmentation of Rat Brain MR Images Using Artificial Neural Network Classifier

Assessment of Carotid Stent Performance: Virtual Tools for a Geometrical Analysis

Design of Retinal Stent Using Finite Element Analysis

High Performance Microfluidic-Based DNA Isolation Chip

Liver Perfusion Analysis Model for Transplantation Using Hybrid Computational Fluid Dynamics Model With Porous Media

Prediction of Interference Free Positions of the Humeral Implant in Preparation of Joint Replacement Procedures

Preliminary Fabrication Capabilities of a 2-Axis Photolithography System Based on Optical Drive Motors and Laser Diodes

Repeatability, Reproducibility, and Calibration of the MyotonPro® on Tissue Mimicking Phantoms

Degradation Behavior of Nanostructured Stent Materials Using Cold Spray

Effects of Body Weight Modification on Internal Knee Contact Forces During Gait

Thermal Residual Limb Manikin to Test Novel Cooling Technologies for Prosthetic Sockets

Validation of an Open Source Framework for the Simulation of Blood Flow in Rigid and Deformable Vessels

Dynamic Simulation of Muscle Loading During ARED Squat Exercise on the International Space Station

Knee Angle Analysis Using a Wearable Motion Analysis System for Detection and Rehabilitation of Mild Traumatic Brain Injury

An Anchoring Mechanism Used to Implant a Biosensor in the Small Intestine

Identifying the Presence of Dyskinesia in Patients With Parkinson’s Disease From Accelerometer Data

Test Chamber Design for Remotely Deployed Migratory Tracking Tags Used on Large Whales

Effect of Vascular Convexity on Diffusive Delivery of Blood-Borne Substances in Normal and Tumor Tissues

Applying Polynomial Chaos Expansions to Evaluate the Effect of Tissue Non-Homogeneous Properties in Biotransport

Experimental Study of a Hybrid Renal Replacement System

Targeting the Tumor-Draining Lymph Node With Adjuvant Nanoparticles for Cancer Immunotherapy

Blood-Tumor Barrier Normalization Effects on Cytotoxic Drug Delivery to Brain Tumors

Predictions of Drug Distribution During Infusions Into the Brain Using an Axisymmetric Finite Element Biphasic Model That Includes Backflow

Modeling Diffusion and Vesiculation in Defective Human Erythrocyte Membrane

Biofabrication of Multi-Material 3D Neural Constructs Embedded With Patterned PC12 Neural Cell Lines

Elastin-Sprayed Tubular Scaffolds With Microstructures and Nanotextures for Vascular Tissue Engineering

A Novel Perfusion Bioreactor for 3D Cell Culture in Microgravity Conditions

Engineered Microvessels Subjected to Interstitial Flow

Engineered Fibrillar Microenvironments With Controllable Architecture and Mechanics for Studying Cellular Stiffness Sensing

Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions

Turbo Expo: Power for Land, Sea, and Air

Verification and Validation

Water Quality, Drought, Human Health and Engineering Conference

Wind Energy Symposium

World Conference on Innovative Virtual Reality

World Tribology Congress

Effects of Chondroadherin on Cartilage Nanostructure and Biomechanics via Murine Model

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Batista, Michael Hadi, T. Nia Cox, Karen Ortiz, Christine Alan, J. Grodzinsky Heinegård, Dick Han, Lin
Copyright Year	2013
Abstract	While small leucine rich proteins/proteoglycans (SLRPs) are present in very low concentrations in the extracellular matrix (ECM), they have been shown to be critical determinants of the proper ECM assembly and function in connective tissues [1] including bone [2], cornea [3], and cartilage [4]. However, their direct and indirect roles in matrix biomechanics and the potential for osteoarthritis-related dysfunction of cartilage remain unclear. With the advent of new high resolution nanotechnological tools, the direct quantification of cartilage biomechanical properties using murine models can provide important insights into how secondary ECM molecules, such as SLRPs, affect the function and pathology of cartilage [5]. Previous nanoindentation studies of murine cartilage have assessed the effects of maturation and osteoarthritis-like degradation of cartilage on its biomechanical properties [6, 7]. Recently, murine models have received increased attention because of the availability of specific gene-knockout and gene alteration technologies [8]. For example, chondroadherin (CHAD) is a non-collagenous small leucine-rich proteoglycan (SLRP) with α-helix and β-sheet secondary structure, spatially localized in the territorial matrix (MW = 38 kDa) [9]. In articular cartilage, CHAD is distributed non-uniformly with depth [10], and binds to type II collagen and the α2β1 integrin and is hypothesized to function in the communication between chondrocytes and their surrounding matrix, as well as in the regulation of collagen fibril assembly [11, 12] (Fig. 1). The objective of the present study is to explore the role of CHAD and its depletion on the structure and nanomechanical properties of both superficial and middle/deep zone cartilage. The current methods thereby enabled depth-dependent analysis of cartilage nanostructure and dynamic energy-dissipative mechanisms.
Sponsorship	Bioengineering Division
File Format	PDF
ISBN	9780791855607
DOI	10.1115/SBC2013-14516
Volume Number	Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
Conference Proceedings	ASME 2013 Summer Bioengineering Conference
Language	English
Publisher Date	2013-06-26
Publisher Place	Sunriver, Oregon, USA
Access Restriction	Subscribed
Subject Keyword	Biomechanics Proteins Cartilage Cornea Biological tissues Chondrocytes Nanoindentation Manufacturing Bone Resolution (optics) Osteoarthritis
Content Type	Text
Resource Type	Article

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