NDLI: Implementation and Validation of Planar Soft Tissue Structural Constitutive Model

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Fan, Rong Michael, S. Sacks
Copyright Year	2013
Abstract	Constitutive modeling is of fundamental important for numerical simulation and analysis of soft biological tissues. The mechanical behaviors of soft tissues are usually highly nonlinear and anisotropic. The complex behavior is the results from the interaction of tissue microstructure. By incorporating information of fiber orientation and distribution at tissue microscopic scale, the structural model avoids ambiguities in material characterization. Moreover, structural models produce much more information than just simple stress-strain results, but can provide much insight into how soft tissues internally reorganize to external loads by adjusting their internal microstructure. Moreover, it is only through simulation of an entire organ system can such information be derived and provide insight into physiological function. However, accurate implementation and rigorous validation of these models remains very limited. In the present study we implemented a structural constitutive model into a commercial finite element package. The structural model was verified against experiential test data for native bovine pericardium and fetal membrane. In addition to prediction of the mechanical response, we demonstrate how a structural model can provide deeper insights into fiber reorientation and fiber recruitment.
Sponsorship	Bioengineering Division
File Format	PDF
ISBN	9780791855607
DOI	10.1115/SBC2013-14809
Volume Number	Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
Conference Proceedings	ASME 2013 Summer Bioengineering Conference
Language	English
Publisher Date	2013-06-26
Publisher Place	Sunriver, Oregon, USA
Access Restriction	Subscribed
Subject Keyword	Mechanical behavior Membranes Computer simulation Biological tissues Modeling Stress Soft tissues Fibers Simulation Anisotropy Physiology Finite element analysis Constitutive equations Ambiguity
Content Type	Text
Resource Type	Article

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