NDLI: Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis.

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Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kouro, Taku Ichii, Michiko Nishida, Makoto Yokota, Takafumi Garrett, Karla P. Satoh, Yusuke Kincade, Paul W. Oritani, Kenji Takahashi, Isao Kanakura, Yuzuru
Description	Country affiliation: Japan Author Affiliation: Yokota T ( Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.)
Abstract	It has long been known that lymphopoiesis is transiently suppressed during pregnancy, which can be experimentally simulated by estrogen treatment. We now confirm with Rag1/GFP reporter mice that early lymphoid progenitors in the lineage marker(-) c-kit(high) ScaI(+), hematopoietic stem cell-enriched fraction of bone marrow are particularly depressed in these circumstances. Hematopoietic and environmental cells are both potential hormone targets and, because of this complexity, very little is known regarding mechanisms. We have now identified soluble Frizzled-related protein (sFRP)1 as an estrogen-inducible gene in stromal cells, whose expression corresponded to inability to support lymphopoiesis. Bone-lining stromal cells express sFRP1, and the transcripts were elevated by pregnancy or estrogen injection. Estrogen receptor-alpha was essential for both lymphoid suppression and induction of the sFRP family. SFRP1 has been mainly described as an antagonist for complex Wnt signals. However, we found that sFRP1, like Wnt3a, stabilized beta-catenin and blocked early lymphoid progression. Myeloerythroid progenitors were less affected by sFRP1 in culture, which was similar to estrogen with respect to lineage specificity. Hematopoietic stem cells expressed various Frizzled receptors, which markedly declined as they differentiated to lymphoid lineage. Thus, hormonal control of early lymphopoiesis in adults might partly relate to sFRP1 levels.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	9
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bone Marrow Cells Immunology Metabolism Estrogen Receptor Alpha Physiology Glycoproteins Biosynthesis Growth Inhibitors Lymphopoiesis Animals Cells, Cultured Down-regulation Genetics Mice Mice, Inbred Balb C Mice, Knockout Mice, Mutant Strains Pregnancy Solubility Stromal Cells Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Soluble Frizzled-Related Protein 1 Is Estrogen Inducible in Bone Marrow Stromal Cells and Suppresses the Earliest Events in Lymphopoiesis

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Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis.

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Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis.