NDLI: PTPN22 alters the development of regulatory T cells in the thymus.

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PTPN22 alters the development of regulatory T cells in the thymus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Stanford, Stephanie M. Cheung, Jocelyn Bottini, Nunzio Sherman, Linda A. Hamilton-Williams, Emma E. Maine, Christian J. Wicker, Linda S.
Description	Country affiliation: United States Author Affiliation: Maine CJ ( Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA.)
Abstract	PTPN22 encodes a tyrosine phosphatase that inhibits Src-family kinases responsible for Ag receptor signaling in lymphocytes and is strongly linked with susceptibility to a number of autoimmune diseases. As strength of TCR signal is critical to the thymic selection of regulatory T cells (Tregs), we examined the effect of murine PTPN22 deficiency on Treg development and function. In the thymus, numbers of pre-Tregs and Tregs increased inversely with the level of PTPN22. This increase in Tregs persisted in the periphery and could play a key part in the reduced severity observed in the PTPN22-deficient mice of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. This could explain the lack of association of certain autoimmune conditions with PTPN22 risk alleles.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1200150
Journal	The Journal of Immunology
Issue Number	11
Volume Number	188
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Encephalomyelitis, Autoimmune, Experimental Enzymology Immunology Protein Tyrosine Phosphatase, Non-receptor Type 22 Physiology T-lymphocytes, Regulatory Thymus Gland Animals Pathology Mice Mice, Inbred C57bl Mice, Knockout Multiple Sclerosis Biosynthesis Deficiency Up-regulation Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization.

Selective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development.

PTPN22 controls the germinal center by influencing the numbers and activity of T follicular helper cells.

CCR6 regulates the migration of inflammatory and regulatory T cells.

IL7R contributes to experimental autoimmune encephalomyelitis through altered T cell responses and nonhematopoietic cell lineages.

Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation.

Systemic lack of canonical histamine receptor signaling results in increased resistance to autoimmune encephalomyelitis.

Kv1.3 deletion biases T cells towards an immuno-regulatory phenotype and renders mice resistant to autoimmune $encephalomyelitis^{}$

IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development.

PTPN22 alters the development of regulatory T cells in the thymus.

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The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization.

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PTPN22 alters the development of regulatory T cells in the thymus.