NDLI: E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.

Please wait, while we are loading the content...

A quantitative trait locus on chromosome 4 affects cycling of hematopoietic stem and progenitor cells through regulation of TGF-beta 2 responsiveness.

Fas expression on antigen-specific T cells has costimulatory, helper and downregulatory functions in vivo for cytotoxic T cell responses but not for T cell-dependent B cell responses

IL-23 promotes maintenance but not commitment to the Th17 lineage.

OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells.

Calcitonin gene-related peptide biases Langerhans cells toward Th2-type immunity.

Intraclonal competition inhibits the formation of high-affinity antibody-secreting cells.

Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells.

Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis.

Selective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development.

Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen

Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.

Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells.

Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition.

Mycobacterium bovis bacille Calmette-Guérin infection in the CNS suppresses experimental autoimmune encephalomyelitis and Th17 responses in an IFN-gamma-independent manner.

n-3 polyunsaturated fatty acids suppress the localization and activation of signaling proteins at the immunological synapse in murine CD4+ T cells by affecting lipid raft formation.

Loss of protein kinase C theta, Bcl10, or Malt1 selectively impairs proliferation and NF-kappa B activation in the CD4+ T cell subset.

Distinct CDR3 conformations in TCRs determine the level of cross-reactivity for diverse antigens, but not the docking orientation.

Ikaros regulates Notch target gene expression in developing thymocytes.

Polymorphic sites away from the Bw4 epitope that affect interaction of Bw4+ HLA-B with KIR3DL1.

Complete characterization of killer Ig-like receptor (KIR) haplotypes in Mauritian cynomolgus macaques: novel insights into nonhuman primate KIR gene content and organization.

An indispensable role for the chemokine receptor CCR10 in IgA antibody-secreting cell accumulation.

Ly49h-deficient C57BL/6 mice: a new mouse cytomegalovirus-susceptible model remains resistant to unrelated pathogens controlled by the NK gene complex.

Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells.

Prolonged microglial cell activation and lymphocyte infiltration following experimental herpes encephalitis.

Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors.

Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire.

MyD88 signaling is not essential for induction of antigen-specific B cell responses but is indispensable for protection against Streptococcus pneumoniae infection following oral vaccination with attenuated Salmonella expressing PspA antigen.

Functional dichotomy of dendritic cells following interaction with Leishmania braziliensis: infected cells produce high levels of TNF-alpha, whereas bystander dendritic cells are activated to promote T cell responses.

Reversal of thymic stromal lymphopoietin-induced airway inflammation through inhibition of Th2 responses.

Immunodominant epitopes in herpes simplex virus type 2 glycoprotein D are recognized by CD4 lymphocytes from both HSV-1 and HSV-2 seropositive subjects.

Strategic nonmyeloablative conditioning: CD154:CD40 costimulatory blockade at primary bone marrow transplantation promotes engraftment for secondary bone marrow transplantation after engraftment failure.

Immunization with a mimotope of GD2 ganglioside induces CD8+ T cells that recognize cell adhesion molecules on tumor cells.

Year: 2008 Volume: 181 Issue: 8

Year: 2008 Volume: 181 Issue: 7

Year: 2008 Volume: 181 Issue: 6

Year: 2008 Volume: 181 Issue: 5

Year: 2008 Volume: 181 Issue: 4

Year: 2008 Volume: 181 Issue: 3

Year: 2008 Volume: 181 Issue: 2

E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bernstein, Irwin D. Borghesi, Lisa Yang, Qi St Leger, Anthony Martincic, Kathleen Milcarek, Christine Kardava, Lela Varnum-Finney, Barbara
Description	Country affiliation: United States Author Affiliation: Yang Q ( Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.)
Abstract	Little is known about the transcriptional regulators that control the proliferation of multipotent bone marrow progenitors. Understanding the mechanisms that restrict proliferation is of significant interest since the loss of cell cycle integrity can be associated with hematopoietic exhaustion, bone marrow failure, or even oncogenic transformation. Herein, we show that multipotent LSKs (lineage(-)Sca(high)c-kit(+)) from E47-deficient mice exhibit a striking hyperproliferation associated with a loss of cell cycle quiescence and increased susceptibility to in vivo challenge with a mitotoxic drug. Total LSKs contain long-term self-renewing hematopoietic stem cells and downstream multipotential progenitors (MPPs) that possess very limited or no self-renewal ability. Within total LSKs, we found specific developmental and functional deficits in the MPP subset. E47 knockout mice have grossly normal numbers of self-renewing hematopoietic stem cells but a 50-70% reduction in nonrenewing MPPs and downstream lineage-restricted populations. The residual MPPs in E47 knockout mice fail to fully up-regulate flk2 or initiate V(D)J recombination, hallmarks of normal lymphoid lineage progression. Consistent with the loss of normal cell cycle restraints, we show that E47-deficient LSKs have a 50% decrease in p21, a cell cycle inhibitor and known regulator of LSK proliferation. Moreover, enforced expression studies identify p21 as an E47 target gene in primary bone marrow LSKs. Thus, E47 appears to regulate the developmental and functional integrity of early hematopoietic subsets in part through effects on p21-mediated cell cycle quiescence.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	9
Volume Number	181
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2008-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Cycle Immunology Cell Differentiation Hematopoietic Stem Cells Metabolism Multipotent Stem Cells G0 Phase Tcf Transcription Factors Physiology Animals Genetics Cell Line Cell Lineage Cyclin-dependent Kinase Inhibitor P21 Gene Targeting Cytology Mice Mice, Knockout Mice, Transgenic Biosynthesis Deficiency Transcription Factor 7-like 1 Protein Transduction, Genetic Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors1

Cell-intrinsic in vivo requirement for the E47-p21 pathway in long-term hematopoietic stem cells.

The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal.

Hematopoietic Multipotent Progenitors and Plasma Cells: Neighbors or Roommates in the Mouse Bone Marrow Ecosystem?

Direction-selective retinal ganglion cells arise from molecularly specified multipotential progenitors.

Ascorbate depletion increases quiescence and self-renewal potential in hematopoietic stem cells and multipotent progenitors

Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.

Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo.

Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin.

E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.

Similar Documents

E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors1

Cell-intrinsic in vivo requirement for the E47-p21 pathway in long-term hematopoietic stem cells.

The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal.

Hematopoietic Multipotent Progenitors and Plasma Cells: Neighbors or Roommates in the Mouse Bone Marrow Ecosystem?

Direction-selective retinal ganglion cells arise from molecularly specified multipotential progenitors.

Ascorbate depletion increases quiescence and self-renewal potential in hematopoietic stem cells and multipotent progenitors

Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.

Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo.

Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin.

E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.