NDLI: Vaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic.

Please wait, while we are loading the content...

The IL-2 diphtheria toxin fusion protein denileukin diftitox modulates the onset of diabetes in female nonobese diabetic animals in a time-dependent manner and breaks tolerance in male nonobese diabetic animals.

Redundant and nonredundant functions of ATM and H2AX in ß T-lineage lymphocytes.

B7-CD28 costimulatory signals control the survival and proliferation of murine and human Î³Î´ T cells via IL-2 production.

Cutting edge: Clec9A+ dendritic cells mediate the development of experimental cerebral malaria.

Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.

Helminth infection impairs autophagy-mediated killing of bacterial enteropathogens by macrophages.

Substrate rigidity regulates human T cell activation and proliferation.

Species selectivity in poxviral complement regulators is dictated by the charge reversal in the central complement control protein modules.

µ-chain-deficient mice possess B-1 cells and produce IgG and IgE, but not IgA, following systemic sensitization and inhalational challenge in a fungal asthma model.

Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice.

Critical role for CCAAT/enhancer-binding protein ß in immune complex-induced acute lung injury.

Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity.

Virologically suppressed HIV patients show activation of NK cells and persistent innate immune activation.

Human bocavirus NP1 inhibits IFN-ß production by blocking association of IFN regulatory factor 3 with IFNB promoter.

Vaccines expressing the innate immune modulator EAT-2 elicit potent effector memory T lymphocyte responses despite pre-existing vaccine immunity.

Cathepsin B controls the persistence of memory CD8+ T lymphocytes.

Multieffector-functional immune responses of HMBPP-specific VÎ³2VÎ´2 T cells in nonhuman primates inoculated with Listeria monocytogenes ΔactA prfA*.

Vaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic.

Retinal laser burn-induced neuropathy leads to substance P-dependent loss of ocular immune privilege.

Transcriptional regulator Id2 is required for the CD4 T cell immune response in the development of experimental autoimmune encephalomyelitis.

Extracellularly delivered single-stranded viral RNA causes neurodegeneration dependent on TLR7.

Cell-cell interaction with APC, not IL-23, is required for naive CD4 cells to acquire pathogenicity during Th17 lineage commitment.

Diet-induced obesity alters dendritic cell function in the presence and absence of tumor growth.

Cutting edge: in the absence of TGF-ß signaling in T cells, fewer CD103+ regulatory T cells develop, but exuberant IFN-Î³ production renders mice more susceptible to helminth infection.

The peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics.

Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells.

Chronic activation of the kinase IKKß impairs T cell function and survival.

Targeting Stat3 induces senescence in tumor cells and elicits prophylactic and therapeutic immune responses against breast cancer growth mediated by NK cells and CD4+ T cells.

A protective role for human IL-10-expressing CD4+ T cells in colitis.

Chronic alcohol consumption impairs distribution and compromises circulation of B cells in B16BL6 melanoma-bearing mice.

Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development.

The adjuvant LT-K63 can restore delayed maturation of follicular dendritic cells and poor persistence of both protein- and polysaccharide-specific antibody-secreting cells in neonatal mice.

A regulatory role for IL-10 receptor signaling in development and B cell help of T follicular helper cells in mice.

Noncanonical Notch signaling modulates cytokine responses of dendritic cells to inflammatory stimuli.

Mesenchymal stem/stromal cells induce the generation of novel IL-10-dependent regulatory dendritic cells by SOCS3 activation.

Cutting edge: CTLA-4 on effector T cells inhibits in trans.

Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation.

Endoplasmic reticulum stress response promotes cytotoxic phenotype of CD8 ß+ intraepithelial lymphocytes in a mouse model for Crohn's disease-like ileitis.

Transgenic overexpression of G5PR that is normally augmented in centrocytes impairs the enrichment of high-affinity antigen-specific B cells, increases peritoneal B-1a cells, and induces autoimmunity in aged female mice.

Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3.

Year: 2012 Volume: 189 Issue: 2

Year: 2012 Volume: 189 Issue: 1

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Vaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Piaskowski, Shari M. McCluskie, Michael Ullah, Jakir H. Merson, James R. Trajkovic, Dusko Hammond, Daisy Beheler, Kerry A. Loudon, Peter T. Pierce, Brian G. Fernandes, Carla Muscat-King, Sophie Shoieb, Ahmed Nimityongskul, Francesca A. Christy, Clare Rieger, Melanie Goodwin, David A. Zhang, Ningli Janies, Juliann Sacha, Jonah B. Nixon, Douglas F. Sheppard, Neil C. Wildeboer, Samantha Rakasz, Eva Schenkman, Daniel I. Newman, Laura P. Rong, Sing Simmons, Heather A. Jones, R. Brad Reed, Jason S. Gardner, Joseph P. Ostrowski, Mario A. Chen, Lianchun Kim, In-Jeong Rumpel, Klaus Gebhard, Douglas H. Castrovinci, Philip Gifford, Robert J. Lappin, Patrick B. Tharmanathan, Tharsika Pruimboom-Brees, Ingrid M. Von Pelchrzim, Frederike
Description	Country affiliation: United States Author Affiliation: Sacha JB ( AIDS Vaccine Laboratory and Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53705, USA.)
Abstract	The expression of endogenous retrotransposable elements, including long interspersed nuclear element 1 (LINE-1 or L1) and human endogenous retrovirus, accompanies neoplastic transformation and infection with viruses such as HIV. The ability to engender immunity safely against such self-antigens would facilitate the development of novel vaccines and immunotherapies. In this article, we address the safety and immunogenicity of vaccination with these elements. We used immunohistochemical analysis and literature precedent to identify potential off-target tissues in humans and establish their translatability in preclinical species to guide safety assessments. Immunization of mice with murine L1 open reading frame 2 induced strong CD8 T cell responses without detectable tissue damage. Similarly, immunization of rhesus macaques with human LINE-1 open reading frame 2 (96% identity with macaque), as well as simian endogenous retrovirus-K Gag and Env, induced polyfunctional T cell responses to all Ags, and Ab responses to simian endogenous retrovirus-K Env. There were no adverse safety or pathological findings related to vaccination. These studies provide the first evidence, to our knowledge, that immune responses can be induced safely against this class of self-antigens and pave the way for investigation of them as HIV- or tumor-associated targets.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1200079
Journal	The Journal of Immunology
Issue Number	3
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aids Vaccines Administration & Dosage Immunology Cancer Vaccines Dna Transposable Elements Endogenous Retroviruses Genetics Amino Acid Sequence Animals Disease Models, Animal Metabolism Macaca Mulatta Mice Mice, Inbred Balb C Molecular Sequence Data Env Gene Products, Human Immunodeficiency Virus Gag Gene Products, Human Immunodeficiency Virus Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Vaccination with Vaxfectin(®) adjuvanted SIV DNA induces long-lasting humoral immune responses able to reduce SIVmac251 Viremia.

Short Conserved Sequences of HIV-1 Are Highly Immunogenic and Shift Immunodominance

Vaccinia and other viruses with available vaccines show marked homology with the HIV-1 envelope glycoprotein: the prospect of using existing vaccines to stem the AIDS pandemic.

Comparison of intradermal and intramuscular delivery followed by in vivo electroporation of SIV Env DNA in macaques

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys.

Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.

Vaccination with Cancer- and HIV Infection-associated Endogenous Retrotransposable Elements is Safe and Immunogenic

Targeting the vaginal mucosa with human papillomavirus pseudovirion vaccines delivering simian immunodeficiency virus DNA.

Immunogenicity of Semliki Forest virus based self-amplifying RNA expressing Indian HIV-1C genes in mice.

Vaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic.

Similar Documents

Vaccination with Vaxfectin(®) adjuvanted SIV DNA induces long-lasting humoral immune responses able to reduce SIVmac251 Viremia.

Short Conserved Sequences of HIV-1 Are Highly Immunogenic and Shift Immunodominance

Vaccinia and other viruses with available vaccines show marked homology with the HIV-1 envelope glycoprotein: the prospect of using existing vaccines to stem the AIDS pandemic.

Comparison of intradermal and intramuscular delivery followed by in vivo electroporation of SIV Env DNA in macaques

Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys.

Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.

Vaccination with Cancer- and HIV Infection-associated Endogenous Retrotransposable Elements is Safe and Immunogenic

Targeting the vaginal mucosa with human papillomavirus pseudovirion vaccines delivering simian immunodeficiency virus DNA.

Immunogenicity of Semliki Forest virus based self-amplifying RNA expressing Indian HIV-1C genes in mice.

Vaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic.