NDLI: Targeting the vaginal mucosa with human papillomavirus pseudovirion vaccines delivering simian immunodeficiency virus DNA.

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Targeting the vaginal mucosa with human papillomavirus pseudovirion vaccines delivering simian immunodeficiency virus DNA.

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Year: 2012 Volume: 188 Issue: 1

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Targeting the vaginal mucosa with human papillomavirus pseudovirion vaccines delivering simian immunodeficiency virus DNA.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kutsyna, Galyna Gordon, Shari N. Hidajat, Rachmat Brocca-Cofano, Egidio Roberts, Jeffery N. Fenizia, Claudio Buck, Christopher B. Lowy, Douglas R. Schiller, John T. Hryniewicz, Anna Cuburu, Nicolas Graham, Barney S. Kines, Rhonda C. Bernardo, Marcelino L. Franchini, Genoveffa Miller, Christopher J. Ma, Zhong-Min Robert-Guroff, Marjorie
Description	Country affiliation: United States Author Affiliation: Gordon SN ( Animal Models and Retroviral Vaccines Section, National Institutes of Health, Bethesda, MD 20892, USA.)
Abstract	The majority of HIV infections occur via mucosal transmission. Vaccines that induce memory T and B cells in the female genital tract may prevent the establishment and systemic dissemination of HIV. We tested the immunogenicity of a vaccine that uses human papillomavirus (HPV)-based gene transfer vectors, also called pseudovirions (PsVs), to deliver SIV genes to the vaginal epithelium. Our findings demonstrate that this vaccine platform induces gene expression in the genital tract in both cynomolgus and rhesus macaques. Intravaginal vaccination with HPV16, HPV45, and HPV58 PsVs delivering SIV Gag DNA induced Gag-specific Abs in serum and the vaginal tract, and T cell responses in blood, vaginal mucosa, and draining lymph nodes that rapidly expanded following intravaginal exposure to SIV(mac251.) HPV PsV-based vehicles are immunogenic, which warrant further testing as vaccine candidates for HIV and may provide a useful model to evaluate the benefits and risks of inducing high levels of SIV-specific immune responses at mucosal sites prior to SIV infection.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1101404
Journal	The Journal of Immunology
Issue Number	2
Volume Number	188
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-01-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Dna, Viral Administration & Dosage Gene Products, Gag Genetics Gene Transfer Techniques Papillomavirus Vaccines Simian Immunodeficiency Virus Vagina Immunology Virion Alphapapillomavirus Animals Hek293 Cells Immunity, Mucosal Luminescent Proteins Macaca Fascicularis Macaca Mulatta Papillomavirus Infections Virology Simian Acquired Immunodeficiency Syndrome Metabolism Research Support, N.i.h., Intramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Humoral immunity induced by mucosal and/or systemic SIV-specific vaccine platforms suggests novel combinatorial approaches for enhancing responses.

Targeting the Vaginal Mucosa with Human Papillomavirus Pseudovirion Vaccines delivering SIV DNA

Purification and functional characterization of mucosal IgA from vaccinated and SIV-infected rhesus macaques.

Cutting edge: novel vaccination modality provides significant protection against mucosal infection by highly pathogenic simian immunodeficiency virus.

Broadening of CD8+ cell responses in vaccine-based simian immunodeficiency virus controllers.

Targeting the vaginal mucosa with human papillomavirus pseudovirion vaccines delivering simian immunodeficiency virus DNA.

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Targeting the vaginal mucosa with human papillomavirus pseudovirion vaccines delivering simian immunodeficiency virus DNA.