NDLI: Antigen-driven induction of polyreactive IgM during intracellular bacterial infection.

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Antigen-driven induction of polyreactive IgM during intracellular bacterial infection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Winslow, Gary M. Jones, Derek D. DeIulio, Gregory A.
Description	Country affiliation: United States Author Affiliation: Jones DD ( Department of Biomedical Sciences, University at Albany, Albany, NY 12201, USA.)
Abstract	Polyreactivity is well known as a property of natural IgM produced by B-1 cells. We demonstrate that polyreactive IgM is also generated during infection of mice with Ehrlichia muris, a tick-borne intracellular bacterial pathogen. The polyreactive IgM bound self and foreign Ags, including single-stranded and double-stranded DNA, insulin, thyroglobulin, LPS, influenza virus, and Borrelia burgdorferi. Production of polyreactive IgM during infection was Ag driven, not due to polyclonal B cell activation, as the majority of polyreactive IgM recognized ehrlichial Ag(s), including an immunodominant outer membrane protein. Monoclonal polyreactive IgM derived from T cell-independent spleen plasmablasts, which was germline-encoded, also bound cytoplasmic and nuclear Ags in HEp-2 cells. Polyreactive IgM protected immunocompromised mice against lethal bacterial challenge infection. Serum from human ehrlichiosis patients also contained polyreactive and self-reactive IgM. We propose that polyreactivity increases IgM efficacy during infection but may also exacerbate or mollify the response to foreign and self Ags.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1200878
Journal	The Journal of Immunology
Issue Number	3
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Bacterial Immunology Immunoglobulin M Biosynthesis Intracellular Fluid Microbiology Animals Antigens, T-independent Bacterial Outer Membrane Proteins Administration & Dosage Ehrlichia Ehrlichiosis Blood Metabolism Immunodominant Epitopes Mice Mice, 129 Strain Mice, Inbred C57bl Mice, Knockout Mice, Transgenic Plasma Cells Spleen Pathology Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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