NDLI: Vaccines expressing the innate immune modulator EAT-2 elicit potent effector memory T lymphocyte responses despite pre-existing vaccine immunity.

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Vaccines expressing the innate immune modulator EAT-2 elicit potent effector memory T lymphocyte responses despite pre-existing vaccine immunity.

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Vaccines expressing the innate immune modulator EAT-2 elicit potent effector memory T lymphocyte responses despite pre-existing vaccine immunity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Schuldt, Nathaniel J. Rastall, David P. W. Godbehere, Sarah Liu, Chyong-Jy J. Aldhamen, Yasser Ali Amalfitano, Andrea Seregin, Sergey S.
Description	Country affiliation: United States Author Affiliation: Aldhamen YA ( Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA.)
Abstract	The mixed results from recent vaccine clinical trials targeting HIV-1 justify the need to enhance the potency of HIV-1 vaccine platforms in general. Use of first-generation recombinant adenovirus serotype 5 (rAd5) platforms failed to protect vaccinees from HIV-1 infection. One hypothesis is that the rAd5-based vaccine failed due to the presence of pre-existing Ad5 immunity in many vaccines. We recently confirmed that EAT-2-expressing rAd5 vectors uniquely activate the innate immune system and improve cellular immune responses against rAd5-expressed Ags, inclusive of HIV/Gag. In this study, we report that use of the rAd5-EAT-2 vaccine can also induce potent cellular immune responses to HIV-1 Ags despite the presence of Ad5-specific immunity. Compared to controls expressing a mutant SH2 domain form of EAT-2, Ad5 immune mice vaccinated with an rAd5-wild-type EAT-2 HIV/Gag-specific vaccine formulation significantly facilitated the induction of several arms of the innate immune system. These responses positively correlated with an improved ability of the vaccine to induce stronger effector memory T cell-biased, cellular immune responses to a coexpressed Ag despite pre-existing anti-Ad5 immunity. Moreover, inclusion of EAT-2 in the vaccine mixture improves the generation of polyfunctional cytolytic CD8(+) T cell responses as characterized by enhanced production of IFN-Î³, TNF- , cytotoxic degranulation, and increased in vivo cytolytic activity. These data suggest a new approach whereby inclusion of EAT-2 expression in stringent human vaccination applications can provide a more effective vaccine against HIV-1 specifically in Ad5 immune subjects.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	3
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Aids Vaccines Pharmacology Cancer Vaccines Immunity, Innate Immunologic Memory T-lymphocyte Subsets Immunology Transcription Factors Physiology Genetics Adaptive Immunity Adenoviridae Animals Cell Line Cells, Cultured Genetic Vectors Killer Cells, Natural Metabolism Pathology Mice Mice, Inbred Balb C Mice, Inbred C57bl Biosynthesis Vaccines, Synthetic Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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