NDLI: Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity.

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Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity.

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Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Berzofsky, Jay A. Burke, Donald S. Waldmann, Thomas A. Oh, Sangkon Perera, Liyanage P.
Description	Author Affiliation: Oh S ( Molecular Immunogenetics and Vaccine Research Section, Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.);
Abstract	Vaccine efficacy is determined largely by cellular and humoral immunity as well as long-lasting immunological memory. IL-2 and IL-15 were evaluated in vaccinia vectors expressing HIV gp160 for the establishment of an effective vaccine strategy. Both IL-2 and IL-15 in the vaccinia vector induced strong and long-lasting antibody-mediated immunity as well as a short-term cytotoxic T cell response against HIV gp120. In addition, IL-15 also supported robust CD8+ T cell-mediated long-term immunity, whereas the CD8+ T cell-mediated immunity induced by IL-2 was short-lived. Moreover, we found that the cytokine milieu at the time of priming had surprisingly persistent effects on the character of the memory CD8 T cells long afterward with respect to their fate, functional activities, cytokine receptor expression, and antigen-independent proliferation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	100
Language	English
Publisher	National Academy of Sciences
Publisher Date	2003-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	AIDS Vaccines Administration & Dosage Immunity, Cellular Interleukin-15 Genetics Interleukin-2 Animals B-Lymphocytes Immunology Cytotoxicity, Immunologic Genetic Vectors HIV Envelope Protein Gp160 Immunologic Memory In Vitro Techniques Killer Cells, Natural Lymphocyte Activation Mice Mice, Inbred BALB C T-Lymphocytes, Cytotoxic Vaccinia Virus Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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