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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Messer, Ronald J. Kassiotis, George Carmody, Aaron B. Dittmer, Ulf Myers, Lara Dudley, Jaquelin P. Joedicke, Jara J. Hasenkrug, Kim J. |
| Description | Country affiliation: United States Author Affiliation: Myers L ( Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.) |
| Abstract | Friend virus infection of mice induces the expansion and activation of regulatory T cells (Tregs) that dampen acute immune responses and promote the establishment and maintenance of chronic infection. Adoptive transfer experiments and the expression of neuropilin-1 indicate that these cells are predominantly natural Tregs rather than virus-specific conventional CD4(+) T cells that converted into induced Tregs. Analysis of Treg TCR Vß chain usage revealed a broadly distributed polyclonal response with a high proportionate expansion of the Vß5(+) Treg subset, which is known to be responsive to endogenous retrovirus-encoded superantigens. In contrast to the major population of Tregs, the Vß5(+) subset expressed markers of terminally differentiated effector cells, and their expansion was associated with the level of the antiviral CD8(+) T cell response rather than the level of Friend virus infection. Surprisingly, the expansion and accumulation of the Vß5(+) Tregs was IL-2 independent but dependent on TNF- . These experiments reveal a subset-specific Treg induction by a new pathway. |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.1202951 |
| Journal | The Journal of Immunology |
| Issue Number | 11 |
| Volume Number | 190 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2013-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Friend Murine Leukemia Virus Immunology Interleukin-2 Receptors, Antigen, T-cell, Alpha-beta Metabolism Retroviridae Infections T-lymphocytes, Regulatory Cytology Tumor Necrosis Factor-alpha Animals B-lymphocytes Cd8-positive T-lymphocytes Dendritic Cells Immunophenotyping Mice Phenotype Tumor Virus Infections Research Support, N.i.h., Extramural Research Support, N.i.h., Intramural Research Support, Non-u.s. Gov't Discipline Immunology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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