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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Schiff, Claudine Anginot, Adrienne Espeli, Marion Mancini, Stéphane J. C. Chasson, Lionel |
| Description | Country affiliation: France Author Affiliation: Anginot A ( Centre d'Immunologie de Marseille-Luminy, Faculté des Sciences de Luminy, Aix Marseille University, UM2, Marseille F-13288, France. schiff@ciml.univ-mrs.fr) |
| Abstract | Galectin-1 (GAL1) is an S-type lectin with multiple functions, including the control of B cell homeostasis. GAL1 expression was reported to be under the control of the plasma cell master regulator BLIMP-1. GAL1 was detected at the protein level in LPS-stimulated B cells and was shown to promote Ig secretion in vitro. However, the pattern of GAL1 expression and function of GAL1 in B cells in vivo are still unclear. In this study, we show that, among B cells, GAL1 is only expressed by differentiating plasma cells following T-dependent or T-independent immunization. Using GAL1-deficient mice we demonstrate that GAL1 expression is required for the maintenance of Ag-specific Ig titers and Ab-secreting cell numbers. Using an in vitro differentiation assay we find that GAL1-deficient plasmablasts can develop normally but die rapidly, through caspase 8 activation, under serum starvation-induced death conditions. TUNEL assays show that in vivo-generated GAL1-deficient plasma cells exhibit an increased sensitivity to apoptosis. Taken together, our data indicate that endogenous GAL1 supports plasma cell survival and participates in the regulation of the humoral immune response. |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.1201885 |
| Journal | The Journal of Immunology |
| Issue Number | 11 |
| Volume Number | 190 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2013-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Galectin 1 Metabolism Homeostasis Immunology Immunity, Humoral Plasma Cells Animals Antigens Apoptosis Genetics B-lymphocytes Immunoglobulin G Blood Immunophenotyping Lymphocyte Count Mice Mice, Knockout Cytology Spleen Research Support, Non-u.s. Gov't Discipline Immunology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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