NDLI: Functional heterogeneity in the CD4+ T cell response to murine Î³-herpesvirus 68.

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Functional heterogeneity in the CD4+ T cell response to murine Î³-herpesvirus 68.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Blackman, Marcia A. Kaye, Kenneth M. Usherwood, Edward J. Hu, Zhuting
Description	Author Affiliation: Hu Z ( Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756); Blackman MA ( Trudeau Institute, Saranac Lake, NY 12983); Kaye KM ( Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115.); Usherwood EJ ( Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756)
Abstract	CD4(+) T cells are critical for the control of virus infections, T cell memory, and immune surveillance. We studied the differentiation and function of murine Î³-herpesvirus 68 (MHV-68)-specific CD4(+) T cells using gp150-specific TCR-transgenic mice. This allowed a more detailed study of the characteristics of the CD4(+) T cell response than did previously available approaches for this virus. Most gp150-specific CD4(+) T cells expressed T-bet and produced IFN-Î³, indicating that MHV-68 infection triggered differentiation of CD4(+) T cells largely into the Th1 subset, whereas some became follicular Th cells and Foxp3(+) regulatory T cells. These CD4(+) T cells were protective against MHV-68 infection in the absence of CD8(+) T cells and B cells, and protection depended on IFN-Î³ secretion. Marked heterogeneity was observed in the CD4(+) T cells, based on lymphocyte Ag 6C (Ly6C) expression. Ly6C expression positively correlated with IFN-Î³, TNF- , and granzyme B production; T-bet and KLRG1 expression; proliferation; and CD4(+) T cell-mediated cytotoxicity. Ly6C expression inversely correlated with survival, CCR7 expression, and secondary expansion potential. Ly6C(+) and Ly6C(-) gp150-specific CD4(+) T cells were able to interconvert in a bidirectional manner upon secondary Ag exposure in vivo. These results indicate that Ly6C expression is closely associated with antiviral activity in effector CD4(+) T cells but is inversely correlated with memory potential. Interconversion between Ly6C(+) and Ly6C(-) cells may maintain a balance between the two Ag-specific CD4(+) T cell populations during MHV-68 infection. These findings have significant implications for Ly6C as a surface marker to distinguish functionally distinct CD4(+) T cells during persistent virus infection.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1401928
Journal	The Journal of Immunology
Issue Number	6
Volume Number	194
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2015-03-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd4-positive T-lymphocytes Immunology Herpesviridae Infections Rhadinovirus Tumor Virus Infections Animals Antigens, Ly Metabolism Apoptosis Genetics B-lymphocytes Cd8-positive T-lymphocytes Cell Differentiation Cell Survival Flow Cytometry Virology Host-pathogen Interactions Interferon-gamma Mice, Inbred C57bl Mice, Knockout Mice, Transgenic Physiology Spleen Pathology T-lymphocytes, Regulatory Th1 Cells Tumor Necrosis Factor-alpha Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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