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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Marcatili, Paolo Colombo, Monica Fais, Franco Albesiano, Emilia Morabito, Fortunato Bruno, Silvia Bagnara, Davide Yan, Xiao-Jie Cutrona, Giovanna Ferrarini, Manlio Chiorazzi, Nicholas Ghiotto, Fabio Tenca, Claudya Chailyan, Anna Mazzarello, Andrea N. Tramontano, Anna |
| Description | Country affiliation: Italy Author Affiliation: Marcatili P ( Department of Physics, Sapienza University of Rome, 00185 Rome, Italy. paolo.marcatili@gmail.com) |
| Abstract | Ag selection has been suggested to play a role in chronic lymphocytic leukemia (CLL) pathogenesis, but no large-scale analysis has been performed so far on the structure of the Ag-binding sites (ABSs) of leukemic cell Igs. We sequenced both H and L chain V(D)J rearrangements from 366 CLL patients and modeled their three-dimensional structures. The resulting ABS structures were clustered into a small number of discrete sets, each containing ABSs with similar shapes and physicochemical properties. This structural classification correlates well with other known prognostic factors such as Ig mutation status and recurrent (stereotyped) receptors, but it shows a better prognostic value, at least in the case of one structural cluster for which clinical data were available. These findings suggest, for the first time, to our knowledge, on the basis of a structural analysis of the Ab-binding sites, that selection by a finite quota of antigenic structures operates on most CLL cases, whether mutated or unmutated. |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| Journal | The Journal of Immunology |
| Issue Number | 11 |
| Volume Number | 190 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2013-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Immunoglobulins Chemistry Genetics Leukemia, Lymphocytic, Chronic, B-cell Immunology Antigens Binding Sites Cluster Analysis Gene Expression Hydrophobic And Hydrophilic Interactions Immunoglobulin Heavy Chains Immunoglobulin Variable Region Mortality Models, Molecular Protein Binding Protein Conformation Receptors, Antigen, B-cell Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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