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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sato, Yusuke Schoenberger, Stephen P. Kaisho, Tsuneyasu Asakura, Miki Fujii, Shin-ichiro Shinga, Jun Ezaki, Taichi Hoshino, Katsuaki Kitahara, Shuji Shimizu, Kanako |
| Description | Country affiliation: Japan Author Affiliation: Shimizu K ( Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology, The Institute of Physical and Chemical Research, RIKEN, Yokohama, Kanagawa 230-0045, Japan.) |
| Abstract | A key goal of vaccine immunotherapy is the generation of long-term memory CD8(+) T cells capable of mediating immune surveillance. We discovered a novel intercellular pathway governing the development of potent memory CD8(+) T cell responses against cell-associated Ags that is mediated through cross-presentation by XCR1(+) dendritic cells (DCs). Generation of CD8(+) memory T cells against tumor cells pulsed with an invariant NKT cell ligand depended on cross-talk between XCR1(+) and plasmacytoid DCs that was regulated by IFN- /IFN- R signals. IFN- production by plasmacytoid DCs was stimulated by an OX40 signal from the invariant NKT cells, as well as an HMGB1 signal from the dying tumor cells. These findings reveal a previously unknown pathway of intercellular collaboration for the generation of tumor-specific CD8(+) memory T cells that can be exploited for strategic vaccination in the setting of tumor immunotherapy. |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| Journal | The Journal of Immunology |
| Issue Number | 11 |
| Volume Number | 190 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2013-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cd8-positive T-lymphocytes Immunology Cell Communication Dendritic Cells Immunologic Memory Natural Killer T-cells Animals Cell Line, Tumor Chemotaxis Metabolism Interferon Type I Interleukin-12 Biosynthesis Ligands Mice Neoplasms Signal Transduction Research Support, Non-u.s. Gov't Discipline Immunology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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