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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Agenes, Fabien Sad, Subash Peng, Stanford L. Joseph, Julie Dudani, Renu Tzelepis, Fanny Haddad, Elias K. Sekaly, Rafick-Pierre Maclean, Susanne |
| Description | Country affiliation: Canada Author Affiliation: Tzelepis F ( National Research Council of Canada, Institute for Biological Sciences, Ottawa, Ontario K1A 0R6, Canada.) |
| Abstract | CD8(+) T cells undergo rapid expansion during infection with intracellular pathogens, which is followed by swift and massive culling of primed CD8(+) T cells. The mechanisms that govern the massive contraction and maintenance of primed CD8(+) T cells are not clear. We show in this study that the transcription factor, FoxO3a, does not influence Ag presentation and the consequent expansion of CD8(+) T cell response during Listeria monocytogenes infection, but plays a key role in the maintenance of memory CD8(+) T cells. The effector function of primed CD8(+) T cells as revealed by cytokine secretion and CD107a degranulation was not influenced by inactivation of FoxO3a. Interestingly, FoxO3a-deficient CD8(+) T cells displayed reduced expression of proapoptotic molecules BIM and PUMA during the various phases of response, and underwent reduced apoptosis in comparison with wild-type cells. A higher number of memory precursor effector cells and memory subsets was detectable in FoxO3a-deficient mice compared with wild-type mice. Furthermore, FoxO3a-deficient memory CD8(+) T cells upon transfer into normal or RAG1-deficient mice displayed enhanced survival. These results suggest that FoxO3a acts in a cell-intrinsic manner to regulate the survival of primed CD8(+) T cells. |
| ISSN | 00221767 |
| e-ISSN | 15506606 |
| DOI | 10.4049/jimmunol.1200639 |
| Journal | The Journal of Immunology |
| Issue Number | 3 |
| Volume Number | 190 |
| Language | English |
| Publisher | The American Association of Immunologists |
| Publisher Date | 2013-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cd8-positive T-lymphocytes Immunology Forkhead Transcription Factors Immunologic Memory Listeriosis Lymphocyte Activation Lymphocyte Subsets Animals Antigen Presentation Antigens, Bacterial Apoptosis Apoptosis Regulatory Proteins Biosynthesis Genetics Secretion Cytokines Blood Cytotoxicity, Immunologic Deficiency Homeodomain Proteins L-selectin Listeria Monocytogenes Lymphokines Lysosome-associated Membrane Glycoproteins Membrane Proteins Mice Mice, Inbred C57bl Ovalbumin Proto-oncogene Proteins Receptors, Interleukin-7 Tumor Suppressor Proteins Research Support, Non-u.s. Gov't Discipline Immunology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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