NDLI: HTLV-1 bZIP factor-specific CD4 T cell responses in adult T cell leukemia/lymphoma patients after allogeneic hematopoietic stem cell transplantation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Masaki, Ayako Yamada, Tomiko Utsunomiya, Atae Ishida, Takashi Niimi, Akio Mori, Fumiko Ri, Masaki Komatsu, Hirokazu Narita, Tomoko Ito, Asahi Miyazaki, Yasuhiko Iida, Shinsuke Suzuki, Susumu Kusumoto, Shigeru Ueda, Ryuzo Takatsuka, Yoshifusa
Description	Author Affiliation: Narita T ( Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan)
Abstract	We document human T lymphotropic virus type 1 (HTLV-1) bZIP factor (HBZ)-specific CD4 T cell responses in an adult T cell leukemia/lymphoma (ATL) patient after allogeneic hematopoietic stem cell transplantation (HCT) and identified a novel HLA-DRB115:01-restricted HBZ-derived naturally presented minimum epitope sequence, RRRAEKKAADVA (HBZ114-125). This peptide was also presented on HLA-DRB115:02, recognized by CD4 T cells. Notably, HBZ-specific CD4 T cell responses were only observed in ATL patients after allogeneic HCT (4 of 9 patients) and not in nontransplanted ATL patients (0 of 10 patients) or in asymptomatic HTLV-1 carriers (0 of 10 carriers). In addition, in one acute-type patient, HBZ-specific CD4 T cell responses were absent in complete remission before HCT, but they became detectable after allogeneic HCT. We surmise that HTLV-1 transmission from mothers to infants through breast milk in early life induces tolerance to HBZ and results in insufficient HBZ-specific T cell responses in HTLV-1 asymptomatic carriers or ATL patients. In contrast, after allogeneic HCT, the reconstituted immune system from donor-derived cells can recognize virus protein HBZ as foreign, and HBZ-specific immune responses are provoked that contribute to the graft-versus-HTLV-1 effect.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	3
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Basic-leucine Zipper Transcription Factors Immunology Cd4-positive T-lymphocytes Htlv-i Antigens Hematopoietic Stem Cell Transplantation Human T-lymphotropic Virus 1 Leukemia-lymphoma, Adult T-cell Viral Proteins Allografts Amino Acid Sequence Asymptomatic Diseases Chemistry Cd8-positive T-lymphocytes Carrier State Cell Line Epitopes, T-lymphocyte Genotype Graft Vs Leukemia Effect Hla-d Antigens Genetics Interferon-gamma Biosynthesis Surgery Molecular Sequence Data Peptide Fragments Chemical Synthesis Retroviridae Proteins Tumor Necrosis Factor-alpha Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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