NDLI: GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shortman, Ken Vremec, David Brady, Jamie L. Zhan, Yifan Lew, Andrew M. Ko, Hyun-Ja Ryg-Cornejo, Victoria Hansen, Diana S.
Description	Author Affiliation: Ko HJ ( Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia)
Abstract	Although multiple dendritic cell (DC) subsets have the potential to induce Th17 differentiation in vitro, the key DC that is critical in Th17 induction and Th17-mediated disease remains moot. In this study, we revealed that CCR2(+) monocyte-derived DCs (moDCs), but not conventional DCs, were critical for in vivo Th17 induction and autoimmune inflammation. Functional comparison in vitro indicated that moDCs are the most potent type of Th17-inducing DCs compared with conventional DCs and plasmacytoid DCs. Furthermore, we demonstrated that the importance of GM-CSF in Th17 induction and Th17-mediated disease is its endowment of moDCs to induce Th17 differentiation in vivo, although it has little effect on moDC numbers. Our findings identify the in vivo cellular targets that can be selectively manipulated to ameliorate Th17-mediated inflammatory diseases, as well as the mechanism of GM-CSF antagonism in such diseases.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	5
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Autoimmune Diseases Immunology Cell Differentiation Dendritic Cells Granulocyte-macrophage Colony-stimulating Factor Monocytes Th17 Cells Animals Genetics Pathology Cytology Mice Mice, Knockout Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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