NDLI: Smad and NFAT pathways cooperate to induce CD103 expression in human CD8 T lymphocytes.

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Smad and NFAT pathways cooperate to induce CD103 expression in human CD8 T lymphocytes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bluteau, Dominique Bismuth, Georges Mokrani, M'barka Mami-Chouaib, Fathia Klibi, Jihène
Description	Author Affiliation: Mokrani M ( INSERM U753, F-94805 Villejuif, France)
Abstract	The interaction of integrin E(CD103)ß7, often expressed on tumor-infiltrating T lymphocytes, with its cognate ligand, the epithelial cell marker E-cadherin on tumor cells, plays a major role in antitumor CTL responses. CD103 is induced on CD8 T cells upon TCR engagement and exposure to TGF-ß1, abundant within the tumor microenvironment. However, the transcriptional mechanisms underlying the cooperative role of these two signaling pathways in inducing CD103 expression in CD8 T lymphocytes remain unknown. Using a human CTL system model based on a CD8(+)/CD103(-) T cell clone specific of a lung tumor-associated Ag, we demonstrated that the transcription factors Smad2/3 and NFAT-1 are two critical regulators of this process. We also identified promoter and enhancer elements of the human ITGAE gene, encoding CD103, involved in its induction by these transcriptional regulators. Overall, our results explain how TGF-ß1 can participate in CD103 expression on locally TCR-engaged Ag-specific CD8 T cells, thus contributing to antitumor CTL responses and cancer cell destruction.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	5
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Cd Immunology Antigens, Neoplasm Cd8-positive T-lymphocytes Integrin Alpha Chains Lung Neoplasms Nfatc Transcription Factors Smad2 Protein Smad3 Protein Biosynthesis Genetics Metabolism Pathology Hek293 Cells Jurkat Cells Receptors, Antigen, T-cell Response Elements Signal Transduction Transforming Growth Factor Beta1 Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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This information is current as Lymphocytes Induce CD 103 Expression in Human CD 8 T Smad and NFAT Pathways Cooperate To

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Smad and NFAT pathways cooperate to induce CD103 expression in human CD8 T lymphocytes.

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This information is current as Lymphocytes Induce CD 103 Expression in Human CD 8 T Smad and NFAT Pathways Cooperate To

Cross-dressed CD8 +/CD103+ dendritic cells prime CD8+ T cells following vaccination.

Liver-resident CD103+ dendritic cells prime antiviral CD8+ T cells in situ.

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Transplantation of allograft transforming growth factor-ß1 transfected CD103âº lamina propria dendritic cells could effectively induce antigen-specific regulatory T cells in vivo.

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Smad4 promotes differentiation of effector and circulating memory CD8 T cells but is dispensable for tissue-resident memory CD8 T cells.

Smad and NFAT pathways cooperate to induce CD103 expression in human CD8 T lymphocytes.

Transplantation of allograft transforming growth factor-ß1 transfected CD103âº lamina propria dendritic cells could effectively induce antigen-specific regulatory T cells in vivo.