NDLI: Inflammatory cytokines break down intrinsic immunological tolerance of human primary keratinocytes to cytosolic DNA.

Please wait, while we are loading the content...

Year: 2017 Volume: 198

Year: 2016 Volume: 197

Year: 2016 Volume: 196

Year: 2015 Volume: 195

Year: 2015 Volume: 194

Year: 2014 Volume: 193

Year: 2014 Volume: 192

Year: 2014 Volume: 192 Issue: 12

Year: 2014 Volume: 192 Issue: 11

Year: 2014 Volume: 192 Issue: 10

Year: 2014 Volume: 192 Issue: 9

Year: 2014 Volume: 192 Issue: 8

Year: 2014 Volume: 192 Issue: 7

Year: 2014 Volume: 192 Issue: 6

Year: 2014 Volume: 192 Issue: 5

G-CSF drives a posttraumatic immune program that protects the host from infection.

Phosphoinositide 3-kinase Î´ regulates migration and invasion of synoviocytes in rheumatoid arthritis.

Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo.

Endothelial cell-derived chemerin promotes dendritic cell transmigration.

Cell contact-dependent priming and Fc interaction with CD32+ immune cells contribute to the TGN1412-triggered cytokine response.

IL-21 promotes CD4 T cell responses by phosphatidylinositol 3-kinase-dependent upregulation of CD86 on B cells.

E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation.

Type 2 innate lymphoid cells drive CD4+ Th2 cell responses.

Allelic exclusion of IgH through inhibition of E2A in a VDJ recombination complex.

Epigenetic silencing of the human NOS2 gene: Rethinking the role of nitric oxide in human macrophage inflammatory $responses^{}$

NK cells are required for dendritic cell-based immunotherapy at the time of tumor challenge.

Smad and NFAT pathways cooperate to induce CD103 expression in human CD8 T lymphocytes.

Adult thymic epithelium contains nonsenescent label-retaining cells.

Upregulation of GRAIL is associated with impaired CD4 T cell proliferation in sepsis.

B-1a cell diversity: nontemplated addition in B-1a cell Ig is determined by progenitor population and developmental location.

Leukotriene B4 enhances the generation of proinflammatory microRNAs to promote MyD88-dependent macrophage activation.

Galectin-9 signaling through TIM-3 is involved in neutrophil-mediated Gram-negative bacterial killing: an effect abrogated within the cystic fibrosis lung.

The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8.

IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major.

PPAR-Î³/IL-10 axis inhibits MyD88 expression and ameliorates murine polymicrobial sepsis.

CD4+ T cells contain early extrapulmonary tuberculosis (TB) dissemination and rapid TB progression and sustain multieffector functions of CD8+ T and CD3- lymphocytes: mechanisms of CD4+ T cell immunity.

A direct and nonredundant role for thymic stromal lymphopoietin on antiviral CD8 T cell responses in the respiratory mucosa.

IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis.

Antigen-dependent integration of opposing proximal TCR-signaling cascades determines the functional fate of T lymphocytes.

Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program.

Inhibition of the membrane attack complex of the complement system reduces secondary neuroaxonal loss and promotes neurologic recovery after traumatic brain injury in mice.

Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation.

Inflammatory cytokines break down intrinsic immunological tolerance of human primary keratinocytes to cytosolic DNA.

A heterobivalent ligand inhibits mast cell degranulation via selective inhibition of allergen-IgE interactions in vivo.

Human Î³Î´ thymocytes are functionally immature and differentiate into cytotoxic type 1 effector T cells upon IL-2/IL-15 signaling.

Glycoengineering of therapeutic antibodies enhances monocyte/macrophage-mediated phagocytosis and cytotoxicity.

Thiopalmitoylation of altered peptide ligands enhances their protective effects in an animal model of multiple sclerosis.

GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis.

Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1ß in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway.

Involvement of Notch in activation and effector functions of Î³Î´ T cells.

8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors.

IFN-Î³-producing and IL-17-producing Î³Î´ T cells differentiate at distinct developmental stages in murine fetal thymus.

Dynamics of chemokine, cytokine, and growth factor serum levels in BRAF-mutant melanoma patients during BRAF inhibitor treatment.

Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node.

Candida-elicited murine Th17 cells express high Ctla-4 compared with Th1 cells and are resistant to costimulation blockade.

IgA enhances NETosis and release of neutrophil extracellular traps by polymorphonuclear cells via Fc receptor I.

Multiparametric bioinformatics distinguish the CD4/CD8 ratio as a suitable laboratory predictor of combined T cell pathogenesis in HIV infection.

Three tapasin docking sites in TAP cooperate to facilitate transporter stabilization and heterodimerization.

TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8.

Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans.

Decidual neutrophil infiltration is not required for preterm birth in a mouse model of infection-induced preterm labor.

CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis.

Psychological stress in children may alter the immune response.

All-trans retinoic acid triggered antimicrobial activity against Mycobacterium tuberculosis is dependent on NPC2

G-protein-coupled receptor kinase-6 interacts with Activator of G-protein signaling-3 to regulate CXCR2-mediated cellular functions

Standardizing scavenger receptor nomenclature.

Blown away: the unexpected role of lymphotoxin in lymphoid organ development.

True grit: programmed necrosis in antiviral host defense, inflammation, and immunogenicity.

Year: 2014 Volume: 192 Issue: 4

Year: 2014 Volume: 192 Issue: 3

Year: 2014 Volume: 192 Issue: 2

Year: 2014 Volume: 192 Issue: 1

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2012 Volume: 189

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Inflammatory cytokines break down intrinsic immunological tolerance of human primary keratinocytes to cytosolic DNA.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jensen, Simon K. Iversen, Lars Johansen, Claus Jørgensen, Sofie E. Nissen, Sara K. Christiansen, Stig H. Chiliveru, Srikanth Mogensen, Trine H. Jakobsen, Martin R. Rahbek, Stine H. Paludan, Søren R.
Description	Author Affiliation: Chiliveru S ( Department of Biomedicine, Aarhus University, Aarhus DK-8000, Denmark)
Abstract	Keratinocytes are involved in protecting the body from infections and environmental challenges, but also in inflammatory conditions like psoriasis. DNA has emerged as a potent stimulator of innate immune responses, but there is largely no information of how keratinocytes respond to cytosolic DNA. In this study, we report that human keratinocytes are tolerant to cytoplasmic DNA. However, if treated with inflammatory cytokines, keratinocytes gained the capacity to respond to DNA through a mechanism antagonized by the antimicrobial peptide LL37, proposed to be involved in activation and regulation of skin inflammation. The DNA sensor IFN-inducible protein 16 (IFI16) colocalized with DNA and the signaling molecule stimulator of IFN genes (STING) in the cytoplasm only in cytokine-stimulated cells, correlating with recruitment of the essential kinase TANK-binding kinase 1. Moreover, IFI16 was essential for DNA-driven innate immune responses in keratinocytes. Finally, IFI16 was upregulated in psoriasis skin lesions and localized to the cytoplasm in a subpopulation of cells. Collectively, this work suggests that inflammatory environments in the skin can lead to breakdown of tolerance for DNA in keratinocytes, which could contribute to the development of inflammatory diseases.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	5
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cytokines Immunology Cytosol Immune Tolerance Keratinocytes Psoriasis Cathelicidins Cells, Cultured Pathology Membrane Proteins Nuclear Proteins Phosphoproteins Protein-serine-threonine Kinases Up-regulation Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in