NDLI: Adult thymic epithelium contains nonsenescent label-retaining cells.

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Adult thymic epithelium contains nonsenescent label-retaining cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dumont-Lagacé, Maude Perreault, Claude Brochu, Sylvie St-Pierre, Charles
Description	Author Affiliation: Dumont-Lagacé M ( Institute for Research in Immunology and Cancer, University of Montreal, Montreal, Quebec, Canada H3C 3J7.)
Abstract	Progress in our understanding of thymic epithelial cell (TEC) renewal and homeostasis is hindered by the lack of markers for TEC progenitors. Stem and progenitor cell populations display remarkable diversity in their proliferative behavior. In some but not all tissues, stemness is associated with quiescence. The primary goal of our study was to discover whether quiescent cells were present in neonatal and adult TECs. To this end, we used a transgenic label-retaining cell (LRC) assay in which a histone H2B-GFP fusion protein is expressed under the control of the reverse tetracycline-controlled transactivator and the tetracycline operator minimal promoter. In adult mice, we found that both cortical and medullary TECs (cTECs and mTECs) proliferated more actively in females than males. Moreover, we observed three main differences between neonatal and adult TECs: 1) neonatal TECs proliferated more actively than adult TECs; 2) whereas cTECs and mTECs had similar turnover rates in young mice, the turnover of mTECs was more rapid than that of cTECs in adults; and 3) although no LRCs could be detected in young mice, LRCs were detectable after a 16-wk chase in adults. In female mice, LRCs were found almost exclusively among cTECs and expressed relatively low levels of p16INK4a, p19ARF, and Serpine1, and high levels of Bmi1, Foxn1, Trp63, and Wnt4. We conclude that LRCs in adult TECs are not senescent postmitotic cells and may represent the elusive progenitors responsible for TEC maintenance in the adult thymus.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	5
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Aging Immunology Stem Cells Cytology Thymus Gland Animals Cyclin-dependent Kinase Inhibitor P16 Genetics Epithelium Forkhead Transcription Factors Mice Mice, Transgenic Phosphoproteins Plasminogen Activator Inhibitor 1 Polycomb Repressive Complex 1 Proto-oncogene Proteins Trans-activators Wnt4 Protein Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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