NDLI: Regulatory T cells: new keys for further unlocking the enigma of fetal tolerance and pregnancy complications.

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Regulatory T cells: new keys for further unlocking the enigma of fetal tolerance and pregnancy complications.

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Regulatory T cells: new keys for further unlocking the enigma of fetal tolerance and pregnancy complications.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kinder, Jeremy M. Valent, Amy M. Way, Sing Sing Chaturvedi, Vandana Clark, Dayna R. Ertelt, James M. Xin, Lijun Jiang, Tony T.
Description	Author Affiliation: Jiang TT ( Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229); Chaturvedi V ( Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229); Ertelt JM ( Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229); Kinder JM ( Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229); Clark DR ( Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229); Valent AM ( Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH 45229.); Xin L ( Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229); Way SS ( Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229)
Abstract	The immunological alterations required for successful pregnancy in eutherian placental mammals have remained a scientific enigma since the discovery of MHC haplotype diversity and unique immune signatures among individuals. Within the past 10 years, accumulating data suggest that immune-suppressive regulatory T cells (Tregs) confer essential protective benefits in sustaining tolerance to the semiallogeneic fetus during pregnancy, along with their more established roles in maintaining tolerance to self and 'extended self' commensal Ags that averts autoimmunity. Reciprocally, many human pregnancy complications stemming from inadequacies in fetal tolerance have been associated with defects in maternal Tregs. Thus, further elucidating the immunological shifts during pregnancy not only have direct translational implications for improving perinatal health, they have enormous potential for unveiling new clues about how Tregs work in other biological contexts. In this article, epidemiological data in human pregnancy and complementary animal studies implicating a pivotal protective role for maternal Tregs are summarized.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1400498
Journal	The Journal of Immunology
Issue Number	11
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens Immunology Immune Tolerance Pregnancy Complications T-lymphocytes, Regulatory Animals Pregnancy Pathology Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Regulatory T cells: new keys for further unlocking the enigma of fetal tolerance and pregnancy complications

Dendritic cell function at the maternal-fetal interface.

This information is current as Pregnancy Complications andUnlocking the Enigma of Fetal Tolerance Regulatory T Cells : New Keys for Further

Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise.

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Mechanisms of T cell tolerance towards the allogeneic fetus.

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Xenograft tolerance and immune function of human T cells developing in pig thymus xenografts.

Regulatory T cells: new keys for further unlocking the enigma of fetal tolerance and pregnancy complications.

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Regulatory T cells: new keys for further unlocking the enigma of fetal tolerance and pregnancy complications

Dendritic cell function at the maternal-fetal interface.

This information is current as Pregnancy Complications andUnlocking the Enigma of Fetal Tolerance Regulatory T Cells : New Keys for Further

Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise.

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Regulatory T cells: new keys for further unlocking the enigma of fetal tolerance and pregnancy complications.