NDLI: Soluble HLA-I/peptide monomers mediate antigen-specific CD8 T cell activation through passive peptide exchange with cell-bound HLA-I molecules.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Allard, Mathilde Bernardeau, Karine Benlalam, Houssem Lang, François Florenceau, Laetitia Echasserieau, Klara Labarrière, Nathalie Gervois, Nadine Oger, Romain
Description	Author Affiliation: Allard M ( INSERM, U892, Nantes F-44007, France); Oger R ( INSERM, U892, Nantes F-44007, France); Benlalam H ( INSERM, U892, Nantes F-44007, France); Florenceau L ( INSERM, U892, Nantes F-44007, France); Echasserieau K ( INSERM, U892, Nantes F-44007, France); Bernardeau K ( INSERM, U892, Nantes F-44007, France); Labarrière N ( INSERM, U892, Nantes F-44007, France); Lang F ( INSERM, U892, Nantes F-44007, France); Gervois N ( INSERM, U892, Nantes F-44007, France)
Abstract	Accumulating evidence that serum levels of soluble class I HLA molecules (sHLA-I) can, under various pathological conditions, correlate with disease stage and/or patient survival, has stimulated interest in defining whether sHLA-I can exert immunological functions. However, despite a mounting number of publications suggesting the ability of sHLA-I to affect immune effectors in vitro, the precise underlying mechanism still remains controversial. In this article, we address potential functions of both classical and nonclassical sHLA-I, using soluble recombinant HLA-I/peptide monomers, and clearly demonstrate their ability to trigger Ag-specific activation of CD8 T cells in vitro. Furthermore, we provide strong evidence that this behavior results from the passive transfer of peptides from monomers to T cell-bound HLA-I molecules, allowing for fratricide representation and activation. Hence, we proposed a unifying model of T cell activation by HLA-I/peptide monomers, reappraising the potential involvement of sHLA-I molecules in the immune response.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	11
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cd8-positive T-lymphocytes Immunology Histocompatibility Antigens Class I Peptides Cytology Hela Cells Protein Transport Solubility Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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