NDLI: A soluble form of IL-27R is a natural IL-27 antagonist.

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A soluble form of IL-27R is a natural IL-27 antagonist.

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A soluble form of IL-27R is a natural IL-27 antagonist.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dietrich, Céline Devergne, Odile Ruemmele, Frank M. Candon, Sophie
Description	Author Affiliation: Dietrich C ( Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147, Université Paris Descartes, Sorbonne Paris Cité, 75 015 Paris, France); Candon S ( Institut Necker Enfants Malades, INSERM U1151, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8253, 75 015 Paris, France); Ruemmele FM ( Service de Gastroentérologie Pédiatrique, Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades, 75 015 Paris, France.); Devergne O ( Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147, Université Paris Descartes, Sorbonne Paris Cité, 75 015 Paris, France)
Abstract	IL-27 is a cytokine of the IL-12 family that plays a key role in the regulation of inflammatory and T cell responses. Its receptor is composed of IL-27R and gp130 and activates the STAT pathway. We show in this study, using an ELISA that we developed, that a naturally occurring soluble form of IL-27R (sIL-27R ) is produced by human activated CD4(+) and CD8(+) T cells, B cells, myeloid cells, and various cell lines. sIL-27R is present at a mean concentration of 10,344 ± 1,274 pg/ml in the sera from healthy individuals. Biochemical studies showed that sIL-27R is released as two N-glycosylated variants of â ¼ 90 and â ¼ 70 kDa. In IL-27R -transfected COS7 cells, primary cells, and cell lines, production of sIL-27R is inhibited by the metalloprotease inhibitors GM6001 and TAPI-0. Importantly, natural sIL-27R binds rIL-27, inhibits IL-27 binding to its cell surface receptor, and is a potent inhibitor of IL-27 signaling, as shown by its ability to specifically block IL-27-mediated STAT activation, at low molar excess over IL-27. Also, we found that serum levels of sIL-27R were elevated in patients with Crohn's disease, a Th1-mediated disease. These findings suggest that sIL-27R may play important immunoregulatory functions under normal and pathological conditions.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	11
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Crohn Disease Immunology Interleukins Antagonists & Inhibitors Lymphocyte Activation Lymphocytes Receptors, Interleukin Signal Transduction Animals Cos Cells Cell Line, Tumor Cercopithecus Aethiops Genetics Pathology Stat Transcription Factors Clinical Trial Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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