NDLI: B cells are not essential for Lactobacillus-mediated protection against lethal pneumovirus infection.

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B cells are not essential for Lactobacillus-mediated protection against lethal pneumovirus infection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Garcia-Crespo, Katia E. Domachowske, Joseph B. Gabryszewski, Stanislaw J. Dyer, Kimberly D. Rosenberg, Helene F. Shaffer, Arthur L. Percopo, Caroline M.
Description	Author Affiliation: Percopo CM ( Inflammation Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892); Dyer KD ( Inflammation Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892); Garcia-Crespo KE ( Inflammation Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892); Gabryszewski SJ ( Inflammation Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892); Shaffer AL ( Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892); Domachowske JB ( Department of Pediatrics, State University of New York Upstate Medical University, Syracuse, NY 13210.); Rosenberg HF ( Inflammation Immunobiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892)
Abstract	We have shown previously that priming of respiratory mucosa with live Lactobacillus species promotes robust and prolonged survival from an otherwise lethal infection with pneumonia virus of mice, a property known as heterologous immunity. Lactobacillus priming results in a moderate reduction in virus recovery and a dramatic reduction in virus-induced proinflammatory cytokine production; the precise mechanisms underlying these findings remain to be elucidated. Because B cells have been shown to promote heterologous immunity against respiratory virus pathogens under similar conditions, in this study we explore the role of B cells in Lactobacillus-mediated protection against acute pneumovirus infection. We found that Lactobacillus-primed mice feature elevated levels of airway Igs IgG, IgA, and IgM and lung tissues with dense, B cell (B220(+))-enriched peribronchial and perivascular infiltrates with germinal centers consistent with descriptions of BALT. No B cells were detected in lung tissue of Lactobacillus-primed B cell deficient µMT mice or Jh mice, and Lactobacillus-primed µMT mice had no characteristic infiltrates or airway Igs. Nonetheless, we observed diminished virus recovery and profound suppression of virus-induced proinflammatory cytokines CCL2, IFN-Î³, and CXCL10 in both wild-type and Lactobacillus-primed µMT mice. Furthermore, Lactobacillus plantarum-primed, B cell-deficient µMT and Jh mice were fully protected from an otherwise lethal pneumonia virus of mice infection, as were their respective wild-types. We conclude that B cells are dispensable for Lactobacillus-mediated heterologous immunity and were not crucial for promoting survival in response to an otherwise lethal pneumovirus infection.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1400087
Journal	The Journal of Immunology
Issue Number	11
Volume Number	192
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-lymphocytes Immunology Lactobacillus Lung Pneumovirus Infections Pneumovirus Respiratory Mucosa Animals Antibodies, Bacterial Genetics Cytokines Pathology Virology Mice Mice, Inbred Balb C Research Support, N.i.h., Extramural Research Support, N.i.h., Intramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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