NDLI: Cutting edge: B cells are essential for protective immunity against Salmonella independent of antibody secretion.

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Cutting edge: B cells are essential for protective immunity against Salmonella independent of antibody secretion.

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Cutting edge: B cells are essential for protective immunity against Salmonella independent of antibody secretion.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nanton, Minelva R. Shlomchik, Mark J. Way, Sing Sing McSorley, Stephen J.
Description	Country affiliation: United States Author Affiliation: Nanton MR ( Department of Pediatric Infectious Disease, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School-Twin Cities, Minneapolis, MN 55455, USA. nanto001@umn.edu)
Abstract	Typhoid fever and nontyphoidal bacteremia caused by Salmonella remain critical human health problems. B cells are required for protective immunity to Salmonella, but the mechanism of protection remains unclear. In this study, we immunized wild-type, B cell-deficient, Ab-deficient, and class-switched Ab-deficient mice with attenuated Salmonella and examined protection against secondary infection. As expected, wild-type mice were protected and B cell-deficient mice succumbed to secondary infection. Interestingly, mice with B cells but lacking secreted Ab or class-switched Ab had little deficiency in resistance to Salmonella infection. The susceptibility of B cell-deficient mice correlated with marked reductions in CD4 T cell IFN-Î³ production after secondary infection. Taken together, these data suggest that the primary role of B cells in acquired immunity to Salmonella is via the development of protective T cell immunity.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1201413
Journal	The Journal of Immunology
Issue Number	12
Volume Number	189
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2012-12-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibodies, Bacterial Biosynthesis B-lymphocyte Subsets Immunology Microbiology Salmonella Infections Prevention & Control Salmonella Typhimurium Animals Secretion Immunity, Cellular Mice Mice, Inbred Balb C Mice, Knockout Mice, Transgenic Pathology Pathogenicity Th1 Cells Virulence Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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