NDLI: Themis2 is not required for B cell development, activation, and antibody responses.

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Themis2 is not required for B cell development, activation, and antibody responses.

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Themis2 is not required for B cell development, activation, and antibody responses.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tybulewicz, Victor L. J. Peirce, Matthew J. Wack, Andreas Hartweger, Harald Schweighoffer, Edina Davidson, Sophia
Description	Author Affiliation: Hartweger H ( Medical Research Council, National Institute for Medical Research, London NW7 1AA, United Kingdom); Schweighoffer E ( Medical Research Council, National Institute for Medical Research, London NW7 1AA, United Kingdom); Davidson S ( Medical Research Council, National Institute for Medical Research, London NW7 1AA, United Kingdom); Peirce MJ ( Kennedy Institute of Rheumatology, Imperial College, London W6 8LH, United Kingdom.); Wack A ( Medical Research Council, National Institute for Medical Research, London NW7 1AA, United Kingdom); Tybulewicz VL ( Medical Research Council, National Institute for Medical Research, London NW7 1AA, United Kingdom)
Abstract	Themis1 is a protein implicated in transducing signals from the TCR. Mice deficient in Themis1 show a strong impairment in T cell selection in the thymus and defective T cell activation. The related Themis2 protein is expressed in B cells where it associates with signaling proteins Grb2 and Vav1, and is tyrosine phosphorylated after BCR stimulation. Thus, it has been proposed that Themis2 may transduce BCR signals, and hence play important roles in B cell development and activation. In this article, we show that Themis2 is expressed in all developing subsets of B cells, in mature follicular and marginal zone B cells, and in activated B cells, including germinal center B cells and plasma cells. In contrast, B lineage cells express no other Themis-family genes. Activation of B cells leads to reduced Themis2 expression, although it remains the only Themis-family protein expressed. To analyze the physiological function of Themis2, we generated a Themis2-deficient mouse strain. Surprisingly, we found that Themis2 is not required for B cell development, for activation, or for Ab responses either to model Ags or to influenza viral infection.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1400943
Journal	The Journal of Immunology
Issue Number	2
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-07-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibody Formation Immunology B-lymphocytes Cell Differentiation Intracellular Signaling Peptides And Proteins Lymphocyte Activation Animals Genetics B-lymphocyte Subsets Metabolism Bone Marrow Cell Lineage Cells, Cultured Cytokines Flow Cytometry Gene Expression Immunoblotting Deficiency Lymph Nodes Mice Mice, Inbred C57bl Mice, Knockout Mice, Transgenic Orthomyxoviridae Infections Reverse Transcriptase Polymerase Chain Reaction Spleen Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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