NDLI: Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyme/anti-lysozyme double-transgenic mice.

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Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyme/anti-lysozyme double-transgenic mice.

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Intrinsic B-cell hyporesponsiveness accounts for self-tolerance in lysozyme/anti-lysozyme double-transgenic mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Basten, A. Adams, E. Goodnow, C. C.
Description	Author Affiliation: Adams E ( Centenary Institute for Cancer Medicine and Cell Biology, University of Sydney, New South Wales, Australia.);
Abstract	In double-transgenic mice expressing a gene construct encoding hen egg lysozyme as well as rearranged anti-lysozyme antibody genes, large numbers of anti-lysozyme B cells are present in peripheral lymphoid tissues but are profoundly tolerant. The cellular basis for this form of non-deletional self-tolerance was explored. The tolerant anti-lysozyme B cells from double-transgenic mice were found to produce much less antibody than nontransgenic controls in T-cell-dependent antigen-specific responses, in adoptive transfer in vivo, and in hanging-drop cultures in vitro, as well as in response to stimulation with the nonspecific mitogen lipopolysaccharide. The diminished responsiveness of the tolerant B cells was not due to a reduction in the number of responding B-cell precursors per se nor were suppressor cells detected in titration, depletion, or mixing experiments. Nondeletional tolerance in this model, therefore, appears to result from an intrinsic functional change in the self-reactive B cells themselves.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibody Formation B-Lymphocytes Immunology Immune Tolerance Immunoglobulins Genetics Muramidase Animals Cells, Cultured Lymph Nodes Lymphocyte Depletion Mice Mice, Inbred C57BL Mice, Transgenic Spleen T-Lymphocytes T-Lymphocytes, Regulatory Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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