NDLI: IL-17 promotes murine lupus.

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IL-17 promotes murine lupus.

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Comment on 'Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection'.

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IL-17 promotes murine lupus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	La Cava, Antonio Lourenço, Elaine V. Amarilyo, Gil Shi, Fu-Dong
Description	Author Affiliation: Amarilyo G ( Division of Rheumatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095); Lourenço EV ( Division of Rheumatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095); Shi FD ( Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013.); La Cava A ( Division of Rheumatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095)
Abstract	The proinflammatory activity of IL-17-producing Th17 cells has been associated with the pathogenesis of several autoimmune diseases. In this article, we provide direct evidence for a role of IL-17 in the pathogenesis of systemic lupus erythematosus (SLE). The induction of SLE by pristane in IL-17-sufficient wild-type mice did not occur in IL-17-deficient mice, which were protected from development of lupus autoantibodies and glomerulonephritis. The protection from SLE in IL-17-deficient mice was associated with a reduced frequency of CD3(+)CD4(-)CD8(-) double-negative T cells and an expansion of CD4(+) regulatory T cells, and did not depend on Stat-1 signaling. These data affirm the key role of IL-17 in the pathogenesis of SLE and strengthen the support for IL-17 blockade in the therapy of SLE.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	2
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-07-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Autoantibodies Immunology Interleukin-17 Lupus Erythematosus, Systemic Lupus Nephritis Animals Blood Enzyme-linked Immunosorbent Assay Flow Cytometry Fluorescent Antibody Technique Deficiency Genetics Chemically Induced Mice Mice, Inbred C57bl Mice, Inbred Nzb Mice, Inbred Strains Mice, Knockout T-lymphocyte Subsets Metabolism T-lymphocytes, Regulatory Terpenes Th17 Cells Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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