NDLI: Differential requirement for the IKKß/NF-κB signaling module in regulating TLR- versus RLR-induced type 1 IFN expression in dendritic cells.

Please wait, while we are loading the content...

Year: 2017 Volume: 198

Year: 2016 Volume: 197

Year: 2016 Volume: 196

Year: 2015 Volume: 195

Year: 2015 Volume: 194

Year: 2014 Volume: 193

Year: 2014 Volume: 193 Issue: 12

Year: 2014 Volume: 193 Issue: 11

Year: 2014 Volume: 193 Issue: 10

Year: 2014 Volume: 193 Issue: 9

Year: 2014 Volume: 193 Issue: 8

Year: 2014 Volume: 193 Issue: 7

Year: 2014 Volume: 193 Issue: 6

Year: 2014 Volume: 193 Issue: 5

Inducible nitric oxide synthase in neutrophils and endothelium contributes to ischemic brain injury in mice.

Altered expression of autoimmune regulator in infant down syndrome thymus, a possible contributor to an autoimmune phenotype.

Scavenger receptor function of mouse FcÎ³ receptor III contributes to progression of atherosclerosis in apolipoprotein E hyperlipidemic mice.

Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF- activation.

Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases.

Prostaglandin E2 negatively regulates the production of inflammatory cytokines/chemokines and IL-17 in visceral leishmaniasis.

PTX3 binds MD-2 and promotes TRIF-dependent immune protection in aspergillosis.

Vector-encoded Helicobacter pylori neutrophil-activating protein promotes maturation of dendritic cells with Th1 polarization and improved migration.

GM-CSF-neuroantigen fusion proteins reverse experimental autoimmune encephalomyelitis and mediate tolerogenic activity in adjuvant-primed environments: association with inflammation-dependent, inhibitory antigen presentation.

Modulation of TNF-induced macrophage polarization by synovial fibroblasts.

CD326(lo)CD103(lo)CD11b(lo) dermal dendritic cells are activated by thymic stromal lymphopoietin during contact sensitization in mice.

Laser ablation-inductively coupled plasma mass spectrometry: an emerging technology for detecting rare cells in tissue sections.

Differential requirement for the IKKß/NF-κB signaling module in regulating TLR- versus RLR-induced type 1 IFN expression in dendritic cells.

Macrophage- and neutrophil-derived TNF- instructs skin langerhans cells to prime antiviral immune responses.

Myeloid-derived suppressor cells as a potential therapy for experimental autoimmune myasthenia gravis.

Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus.

High frequency of cytolytic 21-hydroxylase-specific CD8+ T cells in autoimmune Addison's disease patients.

Leishmania promastigotes induce cytokine secretion in macrophages through the degradation of synaptotagmin XI.

Two functionally distinct subsets of mast cells discriminated By IL-2-independent CD25 activities.

Acute and chronic effects of IL-22 on acetaminophen-induced liver injury.

IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function.

Rapid remodeling of tight junctions during paracellular diapedesis in a human model of the blood-brain barrier.

IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia.

Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses.

IFN- exerts opposing effects on activation-induced and IL-7-induced proliferation of T cells that may impair homeostatic maintenance of CD4+ T cell numbers in treated HIV infection.

Noncanonical NF-κB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer.

Thiamine deficiency promotes T cell infiltration in experimental autoimmune encephalomyelitis: the involvement of CCL2.

ADAM9 is a novel product of polymorphonuclear neutrophils: regulation of expression and contributions to extracellular matrix protein degradation during acute lung injury.

IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells.

Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1ß production in response to ß-glucans and the fungal pathogen, Candida albicans.

JNK2 regulates the functional plasticity of naturally occurring T regulatory cells and the enhancement of lung allergic responses.

A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis.

Transcription factor ABF-1 suppresses plasma cell differentiation but facilitates memory B cell formation.

Macrophage depletion abates Porphyromonas gingivalis-induced alveolar bone resorption in mice.

CaMKIV-dependent preservation of mTOR expression is required for autophagy during lipopolysaccharide-induced inflammation and acute kidney injury.

Ubiquitin-specific protease 2b negatively regulates IFN-ß production and antiviral activity by targeting TANK-binding kinase 1.

Intrahepatic activation of naive CD4+ T cells by liver-resident phagocytic cells.

TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells.

Independent of plasmacytoid dendritic cell (pDC) infection, pDC triggered by virus-infected cells mount enhanced type I IFN responses of different composition as opposed to pDC stimulated with free virus.

Inhibition of two temporal phases of HIV-1 transfer from primary Langerhans cells to T cells: the role of langerin.

The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-ß during Chlamydia trachomatis infection.

Specific increase in potency via structure-based design of a TCR.

Cutting edge: generation of effector cells that localize to mucosal tissues and form resident memory CD8 T cells is controlled by mTOR.

Bcl-xL regulates CD1d-mediated antigen presentation to NKT cells by altering CD1d trafficking through the endocytic pathway.

Collaboration between a soluble C-type lectin and calreticulin facilitates white spot syndrome virus infection in shrimp.

Essential role for the lectin pathway in collagen antibody-induced arthritis revealed through use of adenovirus programming complement inhibitor MAp44 expression.

Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk.

Salmonids have an extraordinary complex type I IFN system: characterization of the IFN locus in rainbow trout oncorhynchus mykiss reveals two novel IFN subgroups.

Simulation of B cell affinity maturation explains enhanced antibody cross-reactivity induced by the polyvalent malaria vaccine AMA1.

Human regulatory B cells combine phenotypic and genetic hallmarks with a distinct differentiation fate.

Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease.

Sperm-associated antigen 16 is a novel target of the humoral autoimmune response in multiple sclerosis.

David W. Talmage, M.D. (AAI '54) 1919-2014.

Comment on 'aneurysmal lesions of patients with abdominal aortic aneurysm contain clonally expanded T cells'.

Response to comment on 'aneurysmal lesions of patients with abdominal aortic aneurysm contain clonally expanded T cells'.

Hematopoiesis in steady-state versus stress: self-renewal, lineage fate choice, and the conversion of danger signals into cytokine signals in hematopoietic stem cells.

The multifaceted roles of Bcl11b in thymic and peripheral T cells: impact on immune diseases.

Year: 2014 Volume: 193 Issue: 4

Year: 2014 Volume: 193 Issue: 3

Year: 2014 Volume: 193 Issue: 2

Year: 2014 Volume: 193 Issue: 1

Year: 2014 Volume: 192

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2012 Volume: 189

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Differential requirement for the IKKß/NF-κB signaling module in regulating TLR- versus RLR-induced type 1 IFN expression in dendritic cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	García-Sastre, Adolfo Wang, Junmei Albrecht, Randy A. Wang, Xingyu Hopewell, Emily L. Beg, Amer A. Xie, Mengyu Nogusa, Shoko Balachandran, Siddharth Zheng, Hong
Description	Author Affiliation: Wang X ( Department of Immunology, Moffitt Cancer Center, Tampa, FL 33612); Wang J ( Department of Immunology, Moffitt Cancer Center, Tampa, FL 33612); Zheng H ( Department of Immunology, Moffitt Cancer Center, Tampa, FL 33612); Xie M ( Department of Immunology, Moffitt Cancer Center, Tampa, FL 33612); Hopewell EL ( Department of Immunology, Moffitt Cancer Center, Tampa, FL 33612); Albrecht RA ( Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029); Nogusa S ( Fox Chase Cancer Center, Philadelphia, PA 19111); García-Sastre A ( Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029); Balachandran S ( Fox Chase Cancer Center, Philadelphia, PA 19111); Beg AA ( Department of Immunology, Moffitt Cancer Center, Tampa, FL 33612)
Abstract	Host innate-immune responses are tailored by cell type to control and eradicate specific infectious agents. For example, an acute RNA virus infection can result in high-level expression of type 1 IFNs by both conventional dendritic cells (cDCs) and plasmacytoid dendritic cells (pDCs), but whereas cDCs preferentially use RIG-I-like receptor (RLR) signaling to produce type 1 IFNs, pDCs predominantly use TLRs to induce these cytokines. We previously found that the IκB kinase ß (IKKß)/NF-κB pathway regulates early IFN-ß expression, but not the magnitude of type 1 IFN expression following RLR engagement. In this study, we use IKKß inhibition and mice deficient in IKKß or canonical NF-κB subunits (p50, RelA/p65, and cRel) to demonstrate that the IKKß/NF-κB axis is critical for virus-induced type 1 IFN expression in pDCs, but not in cDCs. We also reveal a crucial and more general requirement for IKKß/NF-κB in TLR- but not RLR-induced expression of type 1 IFNs and inflammatory cytokines. Together, these findings reveal a previously unappreciated specificity of the IKKß/NF-κB signaling axis in regulation of antimicrobial responses by different classes of pattern recognition receptors, and therefore by individual cell types reliant on particular pattern recognition receptors for their innate-immune transcriptional responses.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1400675
Journal	The Journal of Immunology
Issue Number	5
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Dendritic Cells Immunology Gene Expression Regulation I-kappa B Kinase Interferon Type I Nf-kappa B Plasma Cells Signal Transduction Toll-like Receptors Animals Genetics Membrane Proteins Mice Mice, Knockout Nerve Tissue Proteins Research Support, N.i.h., Extramural Research Support, U.s. Gov't, Non-p.h.s. Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in