NDLI: Hematopoiesis in steady-state versus stress: self-renewal, lineage fate choice, and the conversion of danger signals into cytokine signals in hematopoietic stem cells.

Please wait, while we are loading the content...

Year: 2017 Volume: 198

Year: 2016 Volume: 197

Year: 2016 Volume: 196

Year: 2015 Volume: 195

Year: 2015 Volume: 194

Year: 2014 Volume: 193

Year: 2014 Volume: 193 Issue: 12

Year: 2014 Volume: 193 Issue: 11

Year: 2014 Volume: 193 Issue: 10

Year: 2014 Volume: 193 Issue: 9

Year: 2014 Volume: 193 Issue: 8

Year: 2014 Volume: 193 Issue: 7

Year: 2014 Volume: 193 Issue: 6

Year: 2014 Volume: 193 Issue: 5

Inducible nitric oxide synthase in neutrophils and endothelium contributes to ischemic brain injury in mice.

Altered expression of autoimmune regulator in infant down syndrome thymus, a possible contributor to an autoimmune phenotype.

Scavenger receptor function of mouse FcÎ³ receptor III contributes to progression of atherosclerosis in apolipoprotein E hyperlipidemic mice.

Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF- activation.

Neutrophils mediate blood-spinal cord barrier disruption in demyelinating neuroinflammatory diseases.

Prostaglandin E2 negatively regulates the production of inflammatory cytokines/chemokines and IL-17 in visceral leishmaniasis.

PTX3 binds MD-2 and promotes TRIF-dependent immune protection in aspergillosis.

Vector-encoded Helicobacter pylori neutrophil-activating protein promotes maturation of dendritic cells with Th1 polarization and improved migration.

GM-CSF-neuroantigen fusion proteins reverse experimental autoimmune encephalomyelitis and mediate tolerogenic activity in adjuvant-primed environments: association with inflammation-dependent, inhibitory antigen presentation.

Modulation of TNF-induced macrophage polarization by synovial fibroblasts.

CD326(lo)CD103(lo)CD11b(lo) dermal dendritic cells are activated by thymic stromal lymphopoietin during contact sensitization in mice.

Laser ablation-inductively coupled plasma mass spectrometry: an emerging technology for detecting rare cells in tissue sections.

Differential requirement for the IKKß/NF-κB signaling module in regulating TLR- versus RLR-induced type 1 IFN expression in dendritic cells.

Macrophage- and neutrophil-derived TNF- instructs skin langerhans cells to prime antiviral immune responses.

Myeloid-derived suppressor cells as a potential therapy for experimental autoimmune myasthenia gravis.

Zfp318 regulates IgD expression by abrogating transcription termination within the Ighm/Ighd locus.

High frequency of cytolytic 21-hydroxylase-specific CD8+ T cells in autoimmune Addison's disease patients.

Leishmania promastigotes induce cytokine secretion in macrophages through the degradation of synaptotagmin XI.

Two functionally distinct subsets of mast cells discriminated By IL-2-independent CD25 activities.

Acute and chronic effects of IL-22 on acetaminophen-induced liver injury.

IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function.

Rapid remodeling of tight junctions during paracellular diapedesis in a human model of the blood-brain barrier.

IL-17 suppresses immune effector functions in human papillomavirus-associated epithelial hyperplasia.

Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses.

IFN- exerts opposing effects on activation-induced and IL-7-induced proliferation of T cells that may impair homeostatic maintenance of CD4+ T cell numbers in treated HIV infection.

Noncanonical NF-κB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer.

Thiamine deficiency promotes T cell infiltration in experimental autoimmune encephalomyelitis: the involvement of CCL2.

ADAM9 is a novel product of polymorphonuclear neutrophils: regulation of expression and contributions to extracellular matrix protein degradation during acute lung injury.

IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells.

Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1ß production in response to ß-glucans and the fungal pathogen, Candida albicans.

JNK2 regulates the functional plasticity of naturally occurring T regulatory cells and the enhancement of lung allergic responses.

A novel murine cytomegalovirus vaccine vector protects against Mycobacterium tuberculosis.

Transcription factor ABF-1 suppresses plasma cell differentiation but facilitates memory B cell formation.

Macrophage depletion abates Porphyromonas gingivalis-induced alveolar bone resorption in mice.

CaMKIV-dependent preservation of mTOR expression is required for autophagy during lipopolysaccharide-induced inflammation and acute kidney injury.

Ubiquitin-specific protease 2b negatively regulates IFN-ß production and antiviral activity by targeting TANK-binding kinase 1.

Intrahepatic activation of naive CD4+ T cells by liver-resident phagocytic cells.

TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells.

Independent of plasmacytoid dendritic cell (pDC) infection, pDC triggered by virus-infected cells mount enhanced type I IFN responses of different composition as opposed to pDC stimulated with free virus.

Inhibition of two temporal phases of HIV-1 transfer from primary Langerhans cells to T cells: the role of langerin.

The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-ß during Chlamydia trachomatis infection.

Specific increase in potency via structure-based design of a TCR.

Cutting edge: generation of effector cells that localize to mucosal tissues and form resident memory CD8 T cells is controlled by mTOR.

Bcl-xL regulates CD1d-mediated antigen presentation to NKT cells by altering CD1d trafficking through the endocytic pathway.

Collaboration between a soluble C-type lectin and calreticulin facilitates white spot syndrome virus infection in shrimp.

Essential role for the lectin pathway in collagen antibody-induced arthritis revealed through use of adenovirus programming complement inhibitor MAp44 expression.

Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk.

Salmonids have an extraordinary complex type I IFN system: characterization of the IFN locus in rainbow trout oncorhynchus mykiss reveals two novel IFN subgroups.

Simulation of B cell affinity maturation explains enhanced antibody cross-reactivity induced by the polyvalent malaria vaccine AMA1.

Human regulatory B cells combine phenotypic and genetic hallmarks with a distinct differentiation fate.

Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease.

Sperm-associated antigen 16 is a novel target of the humoral autoimmune response in multiple sclerosis.

David W. Talmage, M.D. (AAI '54) 1919-2014.

Comment on 'aneurysmal lesions of patients with abdominal aortic aneurysm contain clonally expanded T cells'.

Response to comment on 'aneurysmal lesions of patients with abdominal aortic aneurysm contain clonally expanded T cells'.

Hematopoiesis in steady-state versus stress: self-renewal, lineage fate choice, and the conversion of danger signals into cytokine signals in hematopoietic stem cells.

The multifaceted roles of Bcl11b in thymic and peripheral T cells: impact on immune diseases.

Year: 2014 Volume: 193 Issue: 4

Year: 2014 Volume: 193 Issue: 3

Year: 2014 Volume: 193 Issue: 2

Year: 2014 Volume: 193 Issue: 1

Year: 2014 Volume: 192

Year: 2013 Volume: 191

Year: 2013 Volume: 190

Year: 2012 Volume: 189

Year: 2012 Volume: 188

Year: 2011 Volume: 187

Year: 2011 Volume: 186

Year: 2010 Volume: 185

Year: 2010 Volume: 184

Year: 2009 Volume: 183

Year: 2009 Volume: 182

Year: 2008 Volume: 181

Hematopoiesis in steady-state versus stress: self-renewal, lineage fate choice, and the conversion of danger signals into cytokine signals in hematopoietic stem cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Borghesi, Lisa
Description	Author Affiliation: Borghesi L ( Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 borghesi@pitt.edu.)
Abstract	Long-term hematopoietic stem cells (LT-HSCs) replenish the innate and adaptive immune compartments throughout life. Although significant progress has defined the major transcription factors that regulate lineage specification, the architectural proteins that globally coordinate DNA methylation, histone modification, and changes in gene expression are poorly defined. Provocative new studies establish the chromatin organizer special AT-rich binding protein 1 (Satb1) as one such global regulator in LT-HSCs. Satb1 is a nuclear organizer that partitions chromatin through the formation of cage-like structures. By integrating epigenetic and transcriptional pathways, Satb1 coordinates LT-HSC division, self-renewal, and lymphoid potential. Unexpected among the assortment of genes under Satb1 control in hematopoietic stem cells (HSCs) are cytokines, a finding that takes on additional importance with the provocative finding that short-term HSCs and downstream multipotent progenitors are potent and biologically relevant cytokine secretors during stress-mediated hematopoiesis. Together, these studies reveal a new mechanism of fate regulation and an unforeseen functional capability of HSCs.
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.1400936
Journal	The Journal of Immunology
Issue Number	5
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cytokines Immunology Hematopoiesis Physiology Hematopoietic Stem Cells Signal Transduction Stress, Physiological Animals Metabolism Dna Methylation Gene Expression Regulation Cytology Histones Matrix Attachment Region Binding Proteins Research Support, N.i.h., Extramural Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in