NDLI: Transcription factor ABF-1 suppresses plasma cell differentiation but facilitates memory B cell formation.

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Transcription factor ABF-1 suppresses plasma cell differentiation but facilitates memory B cell formation.

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Transcription factor ABF-1 suppresses plasma cell differentiation but facilitates memory B cell formation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Su, Shin-Tang Wang, Kuan-Hsiung Lin, Kuo-I Hsieh, Yi-Ting Tsai, Dong-Yan Chiu, Yi-Kai Lin, I-Ying Yang, Shii-Yi
Description	Author Affiliation: Chiu YK ( Genomics Research Center, Academia Sinica, Taipei 115, Taiwan); Lin IY ( Genomics Research Center, Academia Sinica, Taipei 115, Taiwan); Su ST ( Genomics Research Center, Academia Sinica, Taipei 115, Taiwan); Wang KH ( Genomics Research Center, Academia Sinica, Taipei 115, Taiwan); Yang SY ( Genomics Research Center, Academia Sinica, Taipei 115, Taiwan); Tsai DY ( Genomics Research Center, Academia Sinica, Taipei 115, Taiwan); Hsieh YT ( Genomics Research Center, Academia Sinica, Taipei 115, Taiwan); Lin KI ( Genomics Research Center, Academia Sinica, Taipei 115, Taiwan)
Abstract	Ag-primed B cells that result from an immune response can form either memory B cells or Ab-secreting plasma cells; however, the molecular machinery that controls this cellular fate is poorly understood. In this study, we show that activated B cell factor-1 (ABF-1), which encodes a basic helix-loop-helix transcriptional repressor, participates in this regulation. ABF-1 was prevalently expressed in purified memory B cells and induced by T follicular helper cell-mediated signals. ABF-1 expression declined by the direct repression of B lymphocyte-induced maturation protein-1 during differentiation. Ectopic expression of ABF-1 reduced the formation of Ab-secreting cells in an in vitro differentiation system of human memory B cells. Accordingly, knockdown of ABF-1 potentiates the formation of Ab-secreting cells. A transgenic mouse that expresses inducible ABF-1 in a B cell-specific manner was generated to demonstrate that the formation of germinal center and memory B cells was augmented by induced ABF-1 in an immune response, whereas the Ag-specific plasma cell response was dampened. This effect was associated with the ability of ABF-1 to limit cell proliferation. Together, our results demonstrate that ABF-1 facilitates formation of memory B cells but prevents plasma cell differentiation.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	5
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Differentiation Immunology Cell Proliferation Gene Expression Regulation Immunologic Memory Plasma Cells Transcription Factors 3t3 Cells Animals Genetics Mice Mice, Transgenic Cytology Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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