NDLI: Ectopic expression of CD74 in Ikkß-deleted mouse hepatocytes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Koch, Katherine S. Leffert, Hyam L.
Description	Country affiliation: United States Author Affiliation: Koch KS ( Hepatocyte Growth Control and Stem Cell Laboratory, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0636, La Jolla, CA 92093-0636, USA. kskoch@ucsd.edu)
Abstract	CD74, a Type II membrane glycoprotein and MHC class II chaperone involved in antigen processing, is normally expressed by cells associated with the immune system. CD74 also forms heterodimers with CD44 to generate receptors to macrophage migration inhibitory factor (MIF), a proinflammatory cytokine. Following targeted Alb-Cre-mediated deletion of Ikkß in Ikkß(Δhep) mice (Ikkß(F/F):Alb-Cre, a strain highly susceptible to chemically induced hepatotoxicity and hepatocarcinogenesis), CD74 is expressed abundantly by adult hepatocytes throughout liver acini, albeit more intensely in midzonal-to-centrilobular regions. By comparison, CD74 expression is not observed in Ikkß(F/F) hepatocytes, nor is it augmented in the livers of Ikkß(+/+):Alb-Cre mice; CD74 is barely detectable in cultured embryonic fibroblasts from Ikkß(-/-) mice. Microarray profiling shows that constitutive CD74 expression in Ikkß(Δhep) hepatocytes is accompanied by significantly augmented expression of CD44 and key genes associated with antigen processing and host defense, including MHC class II I-A , I-Aß, and I-Eß chains, CIITA and CD86. Taken together, these observations suggest that Ikkß(Δhep) hepatocytes might express functional capacities for class II-restricted antigen presentation and heightened responsiveness to MIF-signaling, and also suggest further roles for intrahepatocellular IKKß in the suppression or inactivation of molecules normally associated with the formation and differentiation of cells of the immune system.
File Format	HTM / HTML
ISSN	00651281
e-ISSN	16180372
DOI	10.1016/j.acthis.2010.03.004
Journal	Acta Histochemica
Issue Number	4
Volume Number	113
Language	English
Publisher	Elsevier
Publisher Date	2011-07-01
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Discipline Histocytochemistry Antigens, Differentiation, B-lymphocyte Biosynthesis Hepatocytes Immunology Metabolism Histocompatibility Antigens Class Ii I-kappa B Kinase Animals Antigen Presentation Genetics Cell Differentiation Cell Transformation, Neoplastic Cells, Cultured Gene Expression Regulation Gene Knockout Techniques Pathology Antagonists & Inhibitors I-kappa B Proteins Intramolecular Oxidoreductases Macrophage Migration-inhibitory Factors Mice Mice, Inbred C57bl Mice, Knockout Signal Transduction Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Cell Biology Histology

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