NDLI: Human regulatory B cells combine phenotypic and genetic hallmarks with a distinct differentiation fate.

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Human regulatory B cells combine phenotypic and genetic hallmarks with a distinct differentiation fate.

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Human regulatory B cells combine phenotypic and genetic hallmarks with a distinct differentiation fate.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Maho-Vaillant, Maud Larbi, Anis Fink, Katja Chua, Edmond Calbo, Sébastien Lin, Wenyu Shadan, Nurhidaya Binte Poidinger, Michael Duan, Kaibo Yi, June Tai Jing Wong, Siew Cheng Cerny, Daniela Musette, Philippe Lum, Josephine Zolezzi, Francesca
Description	Author Affiliation: Lin W ( Biomedical Sciences Institutes, Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648); Cerny D ( Biomedical Sciences Institutes, Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648); Chua E ( Biomedical Sciences Institutes, Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648); Duan K ( Biomedical Sciences Institutes, Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648); Yi JT ( Biomedical Sciences Institutes, Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648); Shadan NB ( Biomedical Sciences Institutes, Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648); Lum J ( Biomedical Sciences Institutes, Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648); Maho-Vaillant M ( INSERM U905, Normandie University, 76183 Rouen, France); Zolezzi F ( Biomedical Sciences Institutes, Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648); Wong SC ( Biomedical Sciences Institutes, Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648); Larbi A ( Biomedical Sciences Institutes, Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648); Fink K ( Biomedical Sciences Institutes, Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648); Musette P ( INSERM U905, Normandie University, 76183 Rouen, France); Poidinger M ( Biomedical Sciences Institutes, Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648); Calbo S ( Biomedical Sciences Institutes, Singapore Immunology Network, Agency for Science, Technology and Research, Singapore 138648)
Abstract	Regulatory B cells (B-reg) produce IL-10 and suppress inflammation in both mice and humans, but limited data on the phenotype and function of these cells have precluded detailed assessment of their contribution to host immunity. In this article, we report that human B-reg cannot be defined based on a phenotype composed of conventional B cell markers, and that IL-10 production can be elicited in both the CD27(+) memory population and naive B cell subset after only a brief stimulation in vitro. We therefore sought to obtain a better definition of IL-10-producing human B-regs using a multiparameter analysis of B cell phenotype, function, and gene expression profile. Exposure to CpG and anti-Ig are the most potent stimuli for IL-10 secretion in human B cells, but microarray analysis revealed that human B cells cotreated with these reagents resulted in only â ¼0.7% of genes being differentially expressed between IL-10(+) and IL-10(-) cells. Instead, connectivity map analysis revealed that IL-10-secreting B cells are those undergoing specific differentiation toward a germinal center fate, and we identified a CD11c(+) B cell subset that was not capable of producing IL-10 even under optimal conditions. Our findings will assist in the identification of a broader range of human pro-B-reg populations that may represent novel targets for immunotherapy.
ISSN	00221767
e-ISSN	15506606
Journal	The Journal of Immunology
Issue Number	5
Volume Number	193
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2014-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-lymphocyte Subsets Immunology Cell Differentiation Interleukin-10 Adjuvants, Immunologic Pharmacology Animals Cytology Drug Effects Genetics Mice Mice, Knockout Oligodeoxyribonucleotides Clinical Trial Research Support, Non-u.s. Gov't Discipline Immunology
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo.

T(H)2 adjuvants: implications for food allergy.

A B-1a cell subset induces Foxp3(-) T cells with regulatory activity through an IL-10-independent pathway.

Infiltrating regulatory B cells control neuroinflammation following viral brain infection.

Role of hepatocyte-derived IL-7 in maintenance of intrahepatic NKT cells and T cells and development of B cells in fetal liver.

Krüppel-like factor 2 (KLF2) is required for phenotypic maintenance but not development of B1 B cells

Leukocyte-associated Ig-like receptor-1-deficient mice have an altered immune cell phenotype.

IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells.

Peritoneal Cavity Regulatory B Cells (B10 Cells) Modulate $IFN-γ^{+}CD4^{+}$ T Cell Numbers During Colitis Development in Mice

Human regulatory B cells combine phenotypic and genetic hallmarks with a distinct differentiation fate.

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Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo.

T(H)2 adjuvants: implications for food allergy.

A B-1a cell subset induces Foxp3(-) T cells with regulatory activity through an IL-10-independent pathway.

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Krüppel-like factor 2 (KLF2) is required for phenotypic maintenance but not development of B1 B cells

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Human regulatory B cells combine phenotypic and genetic hallmarks with a distinct differentiation fate.