NDLI: Decreased microRNA-132 and its function in human non-small cell lung cancer.

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Decreased microRNA-132 and its function in human non-small cell lung cancer.

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Decreased microRNA-132 and its function in human non-small cell lung cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cui, Youbin Liu, Xiyu Yan, Song Pei, Changyan
Description	Author Affiliation: Liu X ( Department of Chest Surgery, The First Bethune Hospital of Jilin University, Changchun, Jilin 130000, P.R. China.); Yan S ( Department of Chest Surgery, The Cancer Hospital of Jilin Province, Changchun, Jilin 130000, P.R. China.); Pei C ( Department of Medical Administration, Jilin Province People's Hospital, Changchun, Jilin 130000, P.R. China.); Cui Y ( Department of Chest Surgery, The First Bethune Hospital of Jilin University, Changchun, Jilin 130000, P.R. China.)
Abstract	MicroRNA132 (miR132) has been shown to be dysregulated in certain types of human malignancies and is associated with tumor progression. However, its function in nonsmall cell lung cancer (NSCLC) and whether it is differentially expressed in this disease, remain unclear. Thus, the aim of the present study was to investigate the effects of miR132 on NSCLC tumorigenesis and progression. Using reverse transcriptionquantitative polymerase chain reaction, miR132 expression was detected in NSCLC cell lines and primary tumor tissues. The association between miR132 expression, and clinicopathological factors and prognosis was assessed using statistical analysis. An MTT assay, ï¬ ow cytometry, Transwell invasion assays and scratch migration assays were conducted in order to examine the proliferation, apoptosis, invasion and migration of NSCLC cells that had been transfected with miR132 mimics or inhibitors. The results showed that miR132 expression levels were significantly downregulated in NSCLC cells compared with that in corresponding noncancerous lung tissues (P<0.001). In addition, reduced miR132 expression was significantly associated with lymph node metastasis (P=0.003), an advanced tumornodemetastasis stage (P<0.001) and shorter overall survival (P<0.001). Multivariate regression analysis confirmed that downregulation of miR132 was an independent predictor of prognosis. Furthermore, transfection of miR132 mimics into the NSCLC cells reduced cell proliferation, invasion and migration, and promoted cell apoptosis. These findings indicate that miR132 may be a novel diagnostic and prognostic marker, as well as a potential target for molecular therapy in NSCLC.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-05-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Carcinoma, Non-small-cell Lung Genetics Gene Expression Regulation, Neoplastic Lung Neoplasms Micrornas Apoptosis Metabolism Mortality Pathology Cell Line, Tumor Cell Movement Cell Proliferation Neoplasm Grading Neoplasm Staging Prognosis Risk Factors Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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