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Fibroblast activation protein in tumor microenvironment: recent progression and implications (review).

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Fibroblast activation protein in tumor microenvironment: recent progression and implications (review).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yang, Li Zi, Fuming Cai, Zhen He, Donghua He, Jingsong Li, Yi
Description	Author Affiliation: Zi F ( Department of Hematology, Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.); He J ( Department of Hematology, Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.); He D ( Department of Hematology, Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.); Li Y ( Department of Hematology, Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.); Yang L ( Department of Hematology, Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.); Cai Z ( Department of Hematology, Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.)
Abstract	Accumulated evidence has demonstrated that the microenvironment of a given tumor is important in determining its drug resistance, tumorigenesis, progression and metastasis. These microenvironments, like tumor cells, are vital targets for cancer therapy. The cross-talk between tumor cells and cancer-associated fibroblasts (CAFs, alternatively termed activated fibroblasts) is crucial in regulating the drug resistance, tumorigenesis, neoplastic progression, angiogenesis, invasion and metastasis of a tumor. Fibroblast activation protein (FAP ) is a transmembrane serine protease and is highly expressed on CAFs present in >90% of human epithelial neoplasms. FAP activity, alongside that of gelatinase and type I collagenase, has become increasingly important in cancer therapy due to its effectiveness in modulating tumor behavior. In this review, recent progression in the knowledge of the role of FAP in tumor microenvironments is discussed.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2015.3197
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-05-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Gelatinases Metabolism Membrane Proteins Neoplasms Pathology Serine Endopeptidases Tumor Microenvironment Animals Cell Transformation, Neoplastic Genetics Enzyme Activation Fibroblasts Antagonists & Inhibitors Chemistry Gene Expression Regulation, Neoplastic Molecular Targeted Therapy Neoplasm Staging Drug Therapy Mortality Prognosis Substrate Specificity Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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