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Evidence for the contribution of genetic variations in regulator of G protein signaling 9 to the genetic susceptibility of heroin dependence.

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Evidence for the contribution of genetic variations in regulator of G protein signaling 9 to the genetic susceptibility of heroin dependence.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhu, Yongsheng Zhang, Hongbo
Description	Author Affiliation: Zhu Y ( College of Forensic Science, Xi'an Jiaotong University, Key Laboratory of Ministry of Public Health for Forensic Science, Xi'an, Shaanxi 710061, P.R. China.); Zhang H ( College of Forensic Science, Xi'an Jiaotong University, Key Laboratory of Ministry of Public Health for Forensic Science, Xi'an, Shaanxi 710061, P.R. China.)
Abstract	Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G protein-coupled receptor signaling pathways. RGS92, a brainspecific splice variant of the RGS9 gene, is highly expressed in the striatum but lowly expressed in the periaqueductal gray and spinal cord, which mediate various actions of morphine and other opiates. In order to identify the markers that contribute to the genetic susceptibility of heroin dependence, the potential association between heroin dependence and 10 single nucleotide polymorphisms (SNPs), including rs8077696, rs8070231, rs2292593, rs2292592, rs9916525, rs1122079, rs4790953, rs1530351, rs4791230 and rs2869577 of the RGS9 gene was evaluated using the MassARRAY system. The present study recruited 425 heroindependent patients and 205 healthy controls. The results revealed that two SNPs (rs1530351 and rs4791230) located in the promoter region of the RGS9 gene, were significantly associated with heroin dependence (P<0.05). The frequency of the C allele in rs1530351 (χ2=8.031, P=0.005, OR=2.079, 95% CI=1.2413.483) and the G allele in rs4791230 (χ2=7.360, P=0.007, OR=2.021, 95% CI=1.2053.389) in the heroindependent patients was significantly higher than that in the controls. Furthermore, linkage disequilibrium was observed in three blocks (D'>0.9) and significantly less TA haplotypes (χ2=4.867, P=0.027, OR=0.442, 95% CI=0.2100.929) were identified in the heroindependent patients, suggesting that they may exhibit protective effects against heroin dependence. These findings indicate a role for RGS9 gene polymorphisms in heroin dependence and may be informative for future genetic or biological studies on heroin dependence.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-05-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Genetic Association Studies Genetic Predisposition To Disease Genetic Variation Heroin Dependence Genetics Rgs Proteins Alleles Gene Frequency Genotype Haplotypes Linkage Disequilibrium Polymorphism, Single Nucleotide Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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