NDLI: Fucoidan protects ARPE-19 cells from oxidative stress via normalization of reactive oxygen species generation through the Ca²â º-dependent ERK signaling pathway.

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Fucoidan protects ARPE-19 cells from oxidative stress via normalization of reactive oxygen species generation through the Ca²â º-dependent ERK signaling pathway.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Xiaoxia Zhao, Haiyan Liang, Hongyan Wang, Qingfa Jiang, Xiaofeng
Description	Author Affiliation: Li X ( Department of Clinical Biochemistry Laboratory, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.); Zhao H ( Department of Ophthalmology, Central Hospital of Liaoyang City, Liaoyang, Liaoning 111000, P.R. China.); Wang Q ( Department of Emergency, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China.); Liang H ( Department of Clinical Biochemistry Laboratory, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.); Jiang X ( Department of Clinical Biochemistry Laboratory, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.)
Abstract	Diabetic retinopathy (DR) is a common complication of diabetes mellitus (DM) and it is the main cause of loss of vision. In previous years, interest in the biological activities of marine organisms has intensified. The effect of fucoidan from the seaweed Fucus vesiculosus on the molecular mechanisms of numerous diseases has been studied, while to date, its effect on DR was yet to be investigated. Therefore, the aim of the present study was to evaluate the role of fucoidan in DR. The human retinal pigment epithelial cell line ARPE19 was exposed to high Dglucose in the presence or absence of fucoidan. Cell viability was monitored using MTT and lactate dehydrogenase assays. The intracellular reactive oxygen species (ROS) generation was measured using fluorescence spectrophotometry. Cell apoptosis was measured by flow cytometry using Annexin Vfluorescein isothiocyanate staining. Ca2+ influx was measured with a calcium imaging system and the activation of the extracellular signalregulated kinase (ERK) protein was evaluated using western blot analysis. The nontoxic fucoidan protected ARPE19 cells from high glucoseinduced cell death and normalized high glucoseinduced generation of ROS. Fucoidan also inhibited high glucoseinduced cell apoptosis, as well as the Ca2+ influx and ERK1/2 phosphorylation in ARPE19 cells. Taken together, these findings indicated that fucoidan protects ARPE19 cells against high glucoseinduced oxidative damage via normalization of ROS generation through the Ca2+dependent ERK signaling pathway.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	5
Volume Number	11
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-05-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Calcium Metabolism Map Kinase Signaling System Drug Effects Oxidative Stress Polysaccharides Pharmacology Reactive Oxygen Species Apoptosis Cell Line Cell Survival Epithelial Cells Extracellular Signal-regulated Map Kinases Glucose Phosphorylation Retinal Pigment Epithelium Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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