NDLI: Resveratrol analog piceatannol restores the palmitic acid-induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti-inflammatory and antioxidative heme oxygenase-1 in human endothelial cells.

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Resveratrol analog piceatannol restores the palmitic acid-induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti-inflammatory and antioxidative heme oxygenase-1 in human endothelial cells.

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Upregulated microRNA-214 enhances cardiac injury by targeting ITCH during coxsackievirus infection.

Ameliorative effects of Gualou Guizhi decoction on inflammation in focal cerebral ischemic-reperfusion injury.

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Association of neonatal necrotizing enterocolitis with myeloid differentiation-2 and GM2 activator protein genetic polymorphisms.

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Efficient labeling in vitro with non-ionic gadolinium magnetic resonance imaging contrast agent and fluorescent transfection agent in bone marrow stromal cells of neonatal rats.

MicroRNA-218 and microRNA-520a inhibit cell proliferation by downregulating E2F2 in hepatocellular carcinoma.

Anti-profibrotic effects of artesunate on bleomycin-induced pulmonary fibrosis in Sprague Dawley rats.

Computational networks of activating transcription factor 3 gene in Huh7 cell lines and hepatitis C virus-infected Huh7 cell lines.

Gliotoxin potentiates osteoblast differentiation by inhibiting nuclear factor-κB signaling.

VP22 mediates intercellular trafficking and enhances the in vitro antitumor activity of PTEN.

Ophiopogonin-D suppresses MDA-MB-435 cell adhesion and invasion by inhibiting matrix metalloproteinase-9.

Ischemic postconditioning regulates cardiomyocyte autophagic activity following ischemia/reperfusion injury.

Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo.

Apoptin-modified human mesenchymal stem cells inhibit growth of lung carcinoma in nude mice.

Knockdown of ubiquitin protein ligase E3A affects proliferation and invasion, and induces apoptosis of breast cancer cells through regulation of annexin A2.

Violacein induces p44/42 mitogen-activated protein kinase-mediated solid tumor cell death and inhibits tumor cell migration.

Regulation of the oncogenic function of distal-less 4 by microRNA-122 in hepatocellular carcinoma.

Calcitriol ameliorates renal damage in a pre-established proteinuria model.

Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme oxygenase-1.

An integrated analysis of the effects of microRNA and mRNA on esophageal squamous cell carcinoma

Arsenic trioxide inhibits breast cancer cell growth via microRNA-328/hERG pathway in MCF-7 cells.

Social defeat stress promotes tumor growth and angiogenesis by upregulating vascular endothelial growth factor/extracellular signal-regulated kinase/matrix metalloproteinase signaling in a mouse model of lung carcinoma.

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Design, expression and characterization of single chain Fv, Mms13 and the single chain Fvmms13 fusion protein.

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Resveratrol analog piceatannol restores the palmitic acid-induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti-inflammatory and antioxidative heme oxygenase-1 in human endothelial cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lee, Ju Hwan Pae, Hyun-Ock Son, Yong Park, Seong Hoon Cheong, Yong-Kwan Chung, Hun-Taeg Jeong, Sun-Oh
Description	Author Affiliation: Jeong SO ( Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan 570749, Republic of Korea.); Son Y ( Department of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, Iksan 570749, Republic of Korea.); Lee JH ( Department of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, Iksan 570749, Republic of Korea.); Cheong YK ( Department of Anesthesiology and Pain Medicine, Wonkwang University School of Medicine, Iksan 570749, Republic of Korea.); Park SH ( Institute for Metabolic Disease, Wonkwang University School of Medicine, Iksan 570749, Republic of Korea.); Chung HT ( Department of Biological Science, University of Ulsan, Ulsan 680749, Republic of Korea.); Pae HO ( Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan 570749, Republic of Korea.)
Abstract	Growing evidence suggests that the elevation of free fatty acids, including palmitic acid (PA), are associated with inflammation and oxidative stress, which may be involved in endothelial dysfunction, characterized by the reduced bioavailability of nitric oxide (NO) synthesized from endothelial NO synthase (eNOS). Heme oxygenase-1 (HO-1) is important in the preservation of NO bioavailability. Piceatannol (Pic), with similar chemical structure to resveratrol, is suggested to possess similar protective effects as resveratrol. In the present study, human umbilical vein endothelial cells (HUVECs), stimulated with PA, were used to examine the endothelial protective effects of Pic. Pic increased the expression of HO-1 via nuclear factor erythroid-2-related factor-2 activation in the HUVECs, and decreased the PA-induced secretions of interleukin-6 and tumor necrosis factor- , and the formation of reactive oxygen species ROS via inhibition of NF-κB activation. Notably, following inhibition of HO-1 activity by tin protoporphryin-IX, Pic did not prevent cytokine secretion, ROS formation, and NF-κB activation in the PA-stimulated HUVECs. PA attenuated insulin-mediated insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation, leading to decreased glucose uptake, and phosphorylation of eNOS, leading to a reduction in the production of NO. Pic effectively mitigated the inhibitory effects of PA on the insulin-mediated phosphorylation of IRS-1 and eNOS, which was not observed following inhibition of HO1 activity. The results of the present study suggested that Pic may have the potential to prevent PA-induced impairment of insulin signaling and eNOS function, by inducing the expression of the anti-inflammatory and antioxidant, HO-1.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2015.3553
Journal	Molecular Medicine Reports
Issue Number	1
Volume Number	12
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-07-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Anti-inflammatory Agents, Non-steroidal Pharmacology Antioxidants Heme Oxygenase-1 Genetics Human Umbilical Vein Endothelial Cells Drug Effects Insulin Metabolism Nitric Oxide Stilbenes Gene Expression Regulation Cytology Insulin Receptor Substrate Proteins Interleukin-6 Metalloporphyrins Nf-e2-related Factor 2 Nf-kappa B Nitric Oxide Synthase Type Iii Oxidants Antagonists & Inhibitors Oxidative Stress Palmitic Acid Protoporphyrins Reactive Oxygen Species Signal Transduction Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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