NDLI: Pirfenidone inhibits proliferation, arrests the cell cycle, and downregulates heat shock protein-47 and collagen type I in rat hepatic stellate cells in vitro.

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Ribonucleotide reductase M2 subunit expression and prognostic value in nasopharyngeal carcinoma.

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Correlation between the expression of DNMT1, and GSTP1 and APC, and the methylation status of GSTP1 and APC in association with their clinical significance in prostate cancer.

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Molecular mechanism underlying the anticancer effect of simvastatin on MDA-MB-231 human breast cancer cells.

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Identification of a mutation in the WISP3 gene in three unrelated families with progressive pseudorheumatoid dysplasia.

Estrogen receptor mediates the effects of notoginsenoside R1 on endotoxin-induced inflammatory and apoptotic responses in H9c2 cardiomyocytes.

Pirfenidone inhibits proliferation, arrests the cell cycle, and downregulates heat shock protein-47 and collagen type I in rat hepatic stellate cells in vitro.

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Protective and reversal effects of conserved dopamine neurotrophic factor on PC12 cells following 6-hydroxydopamine administration.

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Deregulated microRNA species in the plasma and placenta of patients with preeclampsia.

Synergistic effects of combined treatment with simvastatin and exemestane on MCF-7 human breast cancer cells.

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Use of the disulfiram/copper complex for breast cancer chemoprevention in MMTV-erbB2 transgenic mice.

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Basic fibroblast growth factor lentiviral vector-transfected sheep bone marrow mesenchymal stem cells and non-specific osteogenic gene expression.

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Activation of the unfolded protein response in aged human lenses.

Conditioned medium from umbilical cord mesenchymal stem cells induces migration and angiogenesis

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Golgi phosphoprotein 3 expression predicts poor prognosis in patients with prostate cancer undergoing radical prostatectomy.

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Evaluation of the effects of Angelicae dahuricae radix on the morphology and viability of mesenchymal stem cells.

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Effects of glucose-dependent insulinotropic polypeptide receptor knockout and a high-fat diet on cognitive function and hippocampal gene expression in mice.

Identification and function analysis of contrary genes in Dupuytren's contracture.

High-dose insulin inhibits gap junction intercellular communication in vascular smooth muscle cells.

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Lipid metabolism disorders and bone dysfunction--interrelated and mutually regulated (review).

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Investigating polymorphisms in membrane-associated transporter protein SLC45A2, using sucrose transporters as a model.

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Bioinformatics analysis of abnormal DNA methylation in muscle samples from monozygotic twins discordant for type 2 diabetes.

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Enoyl-coenzyme A hydratase short chain 1 silencing attenuates the proliferation of hepatocellular carcinoma by inhibiting epidermal growth factor signaling in vitro and in vivo.

High-mobility group nucleosome-binding domain 2 protein inhibits the invasion of Klebsiella pneumoniae into mouse lungs in vivo.

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Protein identification from dried nipple aspirate fluid on Guthrie cards using mass spectrometry.

Chitosan oligosaccharides in combination with Agaricus blazei Murill extract reduces hepatoma formation in mice with severe combined immunodeficiency.

Effects of pinacidil on changes to the microenvironment around the incision site, of a skin/muscle incision and retraction, in a rat model of postoperative pain.

Mutations in PTF1A are not a common cause for human VATER/VACTERL association or neural tube defects mirroring Danforth's short tail mouse.

Implication of microRNA regulation in para-phenylenediamine-induced cell death and senescence in normal human hair dermal papilla cells.

Ehlers-Danlos syndrome type IV is associated with a novel G984R COL3A1 mutation.

Verifying the markers of ovarian cancer using RNA-seq data.

Acetyl-l-carnitine prevents homocysteine-induced suppression of Nrf2/Keap1 mediated antioxidation in human lens epithelial cells.

MicroRNA-423-5p targets O-GlcNAc transferase to induce apoptosis in cardiomyocytes.

Overexpression of N-myc downstream-regulated gene 1 inhibits human glioma proliferation and invasion via phosphoinositide 3-kinase/AKT pathways.

Somatic mutations in myeloid cell leukemia-1 contribute to the pathogenesis of glioma by prolonging its half-life.

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Somatostatin prevents lipopolysaccharide-induced neurodegeneration in the rat substantia nigra by inhibiting the activation of microglia.

Expression signatures of long non-coding RNAs in early brain injury following experimental subarachnoid hemorrhage.

Nitrogen permease regulator-like 2 enhances sensitivity to oxaliplatin in colon cancer cells.

Emerging role of microRNA-27a in human malignant glioma cell survival via targeting of prohibitin.

Spindle cell oncocytoma of the adenohypophysis: two case reports and a review of the literature.

RNAi-mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo.

Analysis of the microRNA expression profile of normal human dermal papilla cells treated with 5 -dihydrotestosterone.

Apoptosis induced by sonodynamic therapy in human osteosarcoma cells in vitro.

Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray.

Carbamylated low-density lipoprotein attenuates glucose uptake via a nitric oxide-mediated pathway in rat L6 skeletal muscle cells.

Enterovirus 71 induces apoptosis of SHSY5Y human neuroblastoma cells through stimulation of endogenous microRNA let-7b expression.

Generation of transgenic fibroblasts producing doxycycline-inducible human interferon- or erythropoietin for a bovine mammary bioreactor.

Angiotensin-(1-7) stimulates cholesterol efflux from angiotensin II-treated cholesterol-loaded THP-1 macrophages through the suppression of p38 and c-Jun N-terminal kinase signaling.

Trop2 inhibition suppresses the proliferation and invasion of laryngeal carcinoma cells via the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway.

Extracts of Scutellariae Radix inhibit low-density lipoprotein oxidation and the lipopolysaccharide-induced macrophage inflammatory response.

Resveratrol suppresses vascular endothelial growth factor secretion via inhibition of CXC-chemokine receptor 4 expression in ARPE-19 cells.

Upregulation of microRNA-492 induced by epigenetic drug treatment inhibits the malignant phenotype of clear cell renal cell carcinoma in vitro.

Overexpression of Tyro3 receptor tyrosine kinase leads to the acquisition of taxol resistance in ovarian cancer cells.

Cbl participates in shikonin-induced apoptosis by negatively regulating phosphoinositide 3-kinase/protein kinase B signaling.

Apoptosis of HL-60 human leukemia cells induced by Asiatic acid through modulation of B-cell lymphoma 2 family proteins and the mitogen-activated protein kinase signaling pathway.

Epigenetic modification and preliminary investigation of the mechanism of the immune evasion of HL-60 cells.

Vaccarin promotes endothelial cell proliferation in association with neovascularization in vitro and in vivo.

Synergistic effects of valproic acid and arsenic trioxide on RPMI8226 cells in vitro and the possible underlying mechanisms.

Litsea japonica extract inhibits neuronal apoptosis and the accumulation of advanced glycation end products in the diabetic mouse retina.

Effects of OsteoKing on osteoporotic rabbits.

Anti-inflammatory effects of Gualou Guizhi decoction in transient focal cerebral ischemic brains. [Corrected].

Sevoflurane ameliorates intestinal ischemia-reperfusion-induced lung injury by inhibiting the synergistic action between mast cell activation and oxidative stress.

Antibody microarray profiling of osteosarcoma cell serum for identifying potential biomarkers.

Upregulated microRNA-16 as an oncogene in renal cell carcinoma.

A novel molecular probe 131I-K237 targeting tumor angiogenesis in human prostate cancer xenografts.

Association study of polymorphisms in interferon-Î³ receptor genes with the risk of pulmonary tuberculosis.

Effects of cinobufacini injection on cell proliferation and the expression of topoisomerases in human HepG-2 hepatocellular carcinoma cells.

Effects of silencing the ATP-binding cassette protein E1 gene by electroporation on the proliferation and migration of EC109 human esophageal cancer cells.

Differentiation of human umbilical cord mesenchymal stem cells into germ-like cells in mouse seminiferous tubules.

Ser49Gly polymorphism in the ß-adrenergic receptor 1 gene in a population sample from Rio de Janeiro state, Brazil, stratified by self-identified skin color and genetic ancestry.

Blood-brain barrier permeability of Gualou Guizhi granules and neuroprotective effects in ischemia/reperfusion injury.

MicroRNA-21 promotes osteogenic differentiation by targeting small mothers against decapentaplegic 7.

DNA-dependent protein kinase catalytic subunit inhibitor reverses acquired radioresistance in lung adenocarcinoma by suppressing DNA repair.

MicroRNA-133a inhibits proliferation and invasion, and induces apoptosis in gastric carcinoma cells via targeting fascin actin-bundling protein 1.

Modulatory role of resveratrol on cytotoxic activity of cisplatin, sensitization and modification of cisplatin resistance in colorectal cancer cells.

Resveratrol analog piceatannol restores the palmitic acid-induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti-inflammatory and antioxidative heme oxygenase-1 in human endothelial cells.

Tumor necrosis factor-like weak inducer of apoptosis regulates particle-induced inflammatory osteolysis via the p38 mitogen-activated protein kinase signaling pathway.

Connective tissue growth factor stimulates the proliferation, migration and differentiation of lung fibroblasts during paraquat-induced pulmonary fibrosis.

Fetuin-A 742 (C/T) and 766 (C/G) polymorphic sites are associated with increased risk of myocardial infarction in older patients (≥ 40 years of age).

Identification of active ingredients in Wuzhuyu decoction improving migraine in mice by spectral efficiency association.

MicroRNA-509-3p inhibits cancer cell proliferation and migration by targeting the mitogen-activated protein kinase kinase kinase 8 oncogene in renal cell carcinoma.

cDNA microarray analysis of the effect of cantharidin on DNA damage, cell cycle and apoptosis-associated gene expression in NCI-H460 human lung cancer cells in vitro.

Gene expression changes in human mesenchymal stem cells from patients with osteoporosis.

Identification of KRAS and PIK3CA but not BRAF mutations in patients with gastric cancer.

Serum microRNA-125a-5p, a useful biomarker in liver diseases, correlates with disease progression.

High glucose promotes gastric cancer chemoresistance in vivo and in vitro.

Antineoplastic effect of a novel chemopreventive agent, neokestose, on the Caco-2 cell line via inhibition of expression of nuclear factor-κB and cyclooxygenase-2.

Upregulated microRNA-214 enhances cardiac injury by targeting ITCH during coxsackievirus infection.

Ameliorative effects of Gualou Guizhi decoction on inflammation in focal cerebral ischemic-reperfusion injury.

DNA methyltransferase 3, a target of microRNA-29c, contributes to neuronal proliferation by regulating the expression of brain-derived neurotrophic factor.

Association of neonatal necrotizing enterocolitis with myeloid differentiation-2 and GM2 activator protein genetic polymorphisms.

Comparative analysis of the influence of Fructus Ligustri Lucidi on a rat lumbar disc herniation model.

3,3'-Diindolylmethane attenuates cardiac H9c2 cell hypertrophy through 5'-adenosine monophosphate-activated protein kinase- .

Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2 .

Agmatine protects Müller cells from high-concentration glucose-induced cell damage via N-methyl-D-aspartic acid receptor inhibition.

Efficient labeling in vitro with non-ionic gadolinium magnetic resonance imaging contrast agent and fluorescent transfection agent in bone marrow stromal cells of neonatal rats.

MicroRNA-218 and microRNA-520a inhibit cell proliferation by downregulating E2F2 in hepatocellular carcinoma.

Anti-profibrotic effects of artesunate on bleomycin-induced pulmonary fibrosis in Sprague Dawley rats.

Computational networks of activating transcription factor 3 gene in Huh7 cell lines and hepatitis C virus-infected Huh7 cell lines.

Gliotoxin potentiates osteoblast differentiation by inhibiting nuclear factor-κB signaling.

VP22 mediates intercellular trafficking and enhances the in vitro antitumor activity of PTEN.

Ophiopogonin-D suppresses MDA-MB-435 cell adhesion and invasion by inhibiting matrix metalloproteinase-9.

Ischemic postconditioning regulates cardiomyocyte autophagic activity following ischemia/reperfusion injury.

Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo.

Apoptin-modified human mesenchymal stem cells inhibit growth of lung carcinoma in nude mice.

Knockdown of ubiquitin protein ligase E3A affects proliferation and invasion, and induces apoptosis of breast cancer cells through regulation of annexin A2.

Violacein induces p44/42 mitogen-activated protein kinase-mediated solid tumor cell death and inhibits tumor cell migration.

Regulation of the oncogenic function of distal-less 4 by microRNA-122 in hepatocellular carcinoma.

Calcitriol ameliorates renal damage in a pre-established proteinuria model.

Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme oxygenase-1.

An integrated analysis of the effects of microRNA and mRNA on esophageal squamous cell carcinoma

Arsenic trioxide inhibits breast cancer cell growth via microRNA-328/hERG pathway in MCF-7 cells.

Social defeat stress promotes tumor growth and angiogenesis by upregulating vascular endothelial growth factor/extracellular signal-regulated kinase/matrix metalloproteinase signaling in a mouse model of lung carcinoma.

Transforming growth factor-ß, insulin-like growth factor I/insulin-like growth factor I receptor and vascular endothelial growth factor-A: prognostic and predictive markers in triple-negative and non-triple-negative breast cancer.

Design, expression and characterization of single chain Fv, Mms13 and the single chain Fvmms13 fusion protein.

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Pirfenidone inhibits proliferation, arrests the cell cycle, and downregulates heat shock protein-47 and collagen type I in rat hepatic stellate cells in vitro.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Xing Song, Jie Zhou, Shi Yang, Jian-Yong Zhang, Shuai Jiang, Tian-Peng Xiang, Xian-Hong
Description	Author Affiliation: Xiang XH ( Department of Interventional Radiology, The First Affiliated Hospital of Sun YatSen University, Guangzhou, Guangdong 510080, P.R. China.); Jiang TP ( Department of Interventional Radiology, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou 550000, P.R. China.); Zhang S ( Department of Interventional Radiology, Affiliated Cancer Hospital of Guiyang Medical College, Guiyang, Guizhou 550000, P.R. China.); Song J ( Department of Interventional Radiology, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou 550000, P.R. China.); Li X ( Department of Interventional Radiology, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou 550000, P.R. China.); Yang JY ( Department of Interventional Radiology, The First Affiliated Hospital of Sun YatSen University, Guangzhou, Guangdong 510080, P.R. China.); Zhou S ( Department of Interventional Radiology, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou 550000, P.R. China.)
Abstract	Pirfenidone (esbiret) is an established anti-fibrotic and anti-inflammatory drug used to treat idiopathic pulmonary fibrosis. In the present study, the dose-dependent effects of pirfenidone on the cell cycle, proliferation and expression of heat shock protein (HSP)-47 and collagen type I in a cultured rat hepatic stellate cell line (HSC-T6) were investigated. Following pirfenidone treatment, cell proliferation was determined using the cell counting kit-8 assay and the cell cycle was measured using flow cytometry. HSP-47 expression was estimated using western blot analysis and collagen type I mRNA was assessed using reverse transcription quantitative polymerase chain reaction. Pirfenidone induced significant dose-dependent inhibition of proliferation in HSC-T6 cells. Cell viability was unaffected by treatment with pirfenidone (0, 10 or 100 µM) for 24 and 72 h. However, after 24 h, HSC-T6 cells exhibited dose-dependent decreases in HSP-47 protein and collagen I mRNA levels. In conclusion, pirfenidone inhibited HSC-T6 cell proliferation, arrested the cell cycle and reduced the expression of HSP-47 and collagen type I, indicating that pirfenidone may be a promising drug in the treatment of liver fibrosis.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	1
Volume Number	12
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-07-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Anti-inflammatory Agents, Non-steroidal Pharmacology Cell Proliferation Drug Effects Collagen Type I Genetics Down-regulation Hsp47 Heat-shock Proteins Pyridones Animals Blotting, Western Cell Line Cell Survival Metabolism G1 Phase Cell Cycle Checkpoints Hepatic Stellate Cells Cytology Rna, Messenger Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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