NDLI: Acetyl-l-carnitine prevents homocysteine-induced suppression of Nrf2/Keap1 mediated antioxidation in human lens epithelial cells.

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Activation of the unfolded protein response in aged human lenses.

Conditioned medium from umbilical cord mesenchymal stem cells induces migration and angiogenesis

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Protein identification from dried nipple aspirate fluid on Guthrie cards using mass spectrometry.

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Implication of microRNA regulation in para-phenylenediamine-induced cell death and senescence in normal human hair dermal papilla cells.

Ehlers-Danlos syndrome type IV is associated with a novel G984R COL3A1 mutation.

Verifying the markers of ovarian cancer using RNA-seq data.

Acetyl-l-carnitine prevents homocysteine-induced suppression of Nrf2/Keap1 mediated antioxidation in human lens epithelial cells.

MicroRNA-423-5p targets O-GlcNAc transferase to induce apoptosis in cardiomyocytes.

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Somatic mutations in myeloid cell leukemia-1 contribute to the pathogenesis of glioma by prolonging its half-life.

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Somatostatin prevents lipopolysaccharide-induced neurodegeneration in the rat substantia nigra by inhibiting the activation of microglia.

Expression signatures of long non-coding RNAs in early brain injury following experimental subarachnoid hemorrhage.

Nitrogen permease regulator-like 2 enhances sensitivity to oxaliplatin in colon cancer cells.

Emerging role of microRNA-27a in human malignant glioma cell survival via targeting of prohibitin.

Spindle cell oncocytoma of the adenohypophysis: two case reports and a review of the literature.

RNAi-mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo.

Analysis of the microRNA expression profile of normal human dermal papilla cells treated with 5 -dihydrotestosterone.

Apoptosis induced by sonodynamic therapy in human osteosarcoma cells in vitro.

Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray.

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Enterovirus 71 induces apoptosis of SHSY5Y human neuroblastoma cells through stimulation of endogenous microRNA let-7b expression.

Generation of transgenic fibroblasts producing doxycycline-inducible human interferon- or erythropoietin for a bovine mammary bioreactor.

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Trop2 inhibition suppresses the proliferation and invasion of laryngeal carcinoma cells via the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway.

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Overexpression of Tyro3 receptor tyrosine kinase leads to the acquisition of taxol resistance in ovarian cancer cells.

Cbl participates in shikonin-induced apoptosis by negatively regulating phosphoinositide 3-kinase/protein kinase B signaling.

Apoptosis of HL-60 human leukemia cells induced by Asiatic acid through modulation of B-cell lymphoma 2 family proteins and the mitogen-activated protein kinase signaling pathway.

Epigenetic modification and preliminary investigation of the mechanism of the immune evasion of HL-60 cells.

Vaccarin promotes endothelial cell proliferation in association with neovascularization in vitro and in vivo.

Synergistic effects of valproic acid and arsenic trioxide on RPMI8226 cells in vitro and the possible underlying mechanisms.

Litsea japonica extract inhibits neuronal apoptosis and the accumulation of advanced glycation end products in the diabetic mouse retina.

Effects of OsteoKing on osteoporotic rabbits.

Anti-inflammatory effects of Gualou Guizhi decoction in transient focal cerebral ischemic brains. [Corrected].

Sevoflurane ameliorates intestinal ischemia-reperfusion-induced lung injury by inhibiting the synergistic action between mast cell activation and oxidative stress.

Antibody microarray profiling of osteosarcoma cell serum for identifying potential biomarkers.

Upregulated microRNA-16 as an oncogene in renal cell carcinoma.

A novel molecular probe 131I-K237 targeting tumor angiogenesis in human prostate cancer xenografts.

Association study of polymorphisms in interferon-Î³ receptor genes with the risk of pulmonary tuberculosis.

Effects of cinobufacini injection on cell proliferation and the expression of topoisomerases in human HepG-2 hepatocellular carcinoma cells.

Effects of silencing the ATP-binding cassette protein E1 gene by electroporation on the proliferation and migration of EC109 human esophageal cancer cells.

Differentiation of human umbilical cord mesenchymal stem cells into germ-like cells in mouse seminiferous tubules.

Ser49Gly polymorphism in the ß-adrenergic receptor 1 gene in a population sample from Rio de Janeiro state, Brazil, stratified by self-identified skin color and genetic ancestry.

Blood-brain barrier permeability of Gualou Guizhi granules and neuroprotective effects in ischemia/reperfusion injury.

MicroRNA-21 promotes osteogenic differentiation by targeting small mothers against decapentaplegic 7.

DNA-dependent protein kinase catalytic subunit inhibitor reverses acquired radioresistance in lung adenocarcinoma by suppressing DNA repair.

MicroRNA-133a inhibits proliferation and invasion, and induces apoptosis in gastric carcinoma cells via targeting fascin actin-bundling protein 1.

Modulatory role of resveratrol on cytotoxic activity of cisplatin, sensitization and modification of cisplatin resistance in colorectal cancer cells.

Resveratrol analog piceatannol restores the palmitic acid-induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti-inflammatory and antioxidative heme oxygenase-1 in human endothelial cells.

Tumor necrosis factor-like weak inducer of apoptosis regulates particle-induced inflammatory osteolysis via the p38 mitogen-activated protein kinase signaling pathway.

Connective tissue growth factor stimulates the proliferation, migration and differentiation of lung fibroblasts during paraquat-induced pulmonary fibrosis.

Fetuin-A 742 (C/T) and 766 (C/G) polymorphic sites are associated with increased risk of myocardial infarction in older patients (≥ 40 years of age).

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MicroRNA-509-3p inhibits cancer cell proliferation and migration by targeting the mitogen-activated protein kinase kinase kinase 8 oncogene in renal cell carcinoma.

cDNA microarray analysis of the effect of cantharidin on DNA damage, cell cycle and apoptosis-associated gene expression in NCI-H460 human lung cancer cells in vitro.

Gene expression changes in human mesenchymal stem cells from patients with osteoporosis.

Identification of KRAS and PIK3CA but not BRAF mutations in patients with gastric cancer.

Serum microRNA-125a-5p, a useful biomarker in liver diseases, correlates with disease progression.

High glucose promotes gastric cancer chemoresistance in vivo and in vitro.

Antineoplastic effect of a novel chemopreventive agent, neokestose, on the Caco-2 cell line via inhibition of expression of nuclear factor-κB and cyclooxygenase-2.

Upregulated microRNA-214 enhances cardiac injury by targeting ITCH during coxsackievirus infection.

Ameliorative effects of Gualou Guizhi decoction on inflammation in focal cerebral ischemic-reperfusion injury.

DNA methyltransferase 3, a target of microRNA-29c, contributes to neuronal proliferation by regulating the expression of brain-derived neurotrophic factor.

Association of neonatal necrotizing enterocolitis with myeloid differentiation-2 and GM2 activator protein genetic polymorphisms.

Comparative analysis of the influence of Fructus Ligustri Lucidi on a rat lumbar disc herniation model.

3,3'-Diindolylmethane attenuates cardiac H9c2 cell hypertrophy through 5'-adenosine monophosphate-activated protein kinase- .

Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2 .

Agmatine protects Müller cells from high-concentration glucose-induced cell damage via N-methyl-D-aspartic acid receptor inhibition.

Efficient labeling in vitro with non-ionic gadolinium magnetic resonance imaging contrast agent and fluorescent transfection agent in bone marrow stromal cells of neonatal rats.

MicroRNA-218 and microRNA-520a inhibit cell proliferation by downregulating E2F2 in hepatocellular carcinoma.

Anti-profibrotic effects of artesunate on bleomycin-induced pulmonary fibrosis in Sprague Dawley rats.

Computational networks of activating transcription factor 3 gene in Huh7 cell lines and hepatitis C virus-infected Huh7 cell lines.

Gliotoxin potentiates osteoblast differentiation by inhibiting nuclear factor-κB signaling.

VP22 mediates intercellular trafficking and enhances the in vitro antitumor activity of PTEN.

Ophiopogonin-D suppresses MDA-MB-435 cell adhesion and invasion by inhibiting matrix metalloproteinase-9.

Ischemic postconditioning regulates cardiomyocyte autophagic activity following ischemia/reperfusion injury.

Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo.

Apoptin-modified human mesenchymal stem cells inhibit growth of lung carcinoma in nude mice.

Knockdown of ubiquitin protein ligase E3A affects proliferation and invasion, and induces apoptosis of breast cancer cells through regulation of annexin A2.

Violacein induces p44/42 mitogen-activated protein kinase-mediated solid tumor cell death and inhibits tumor cell migration.

Regulation of the oncogenic function of distal-less 4 by microRNA-122 in hepatocellular carcinoma.

Calcitriol ameliorates renal damage in a pre-established proteinuria model.

Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme oxygenase-1.

An integrated analysis of the effects of microRNA and mRNA on esophageal squamous cell carcinoma

Arsenic trioxide inhibits breast cancer cell growth via microRNA-328/hERG pathway in MCF-7 cells.

Social defeat stress promotes tumor growth and angiogenesis by upregulating vascular endothelial growth factor/extracellular signal-regulated kinase/matrix metalloproteinase signaling in a mouse model of lung carcinoma.

Transforming growth factor-ß, insulin-like growth factor I/insulin-like growth factor I receptor and vascular endothelial growth factor-A: prognostic and predictive markers in triple-negative and non-triple-negative breast cancer.

Design, expression and characterization of single chain Fv, Mms13 and the single chain Fvmms13 fusion protein.

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Acetyl-l-carnitine prevents homocysteine-induced suppression of Nrf2/Keap1 mediated antioxidation in human lens epithelial cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cao, Guo-Ping Yang, Shui-Ping Yang, Xiu-Zhen
Description	Author Affiliation: Yang SP ( Department of Ophthalmology, Taizhou People's Hospital, Taizhou, Jiangsu 225499, P.R. China.); Yang XZ ( Department of Hepatic Disease, Taizhou People's Hospital, Taizhou, Jiangsu 225499, P.R. China.); Cao GP ( Department of Ophthalmology, Taizhou People's Hospital, Taizhou, Jiangsu 225499, P.R. China.)
Abstract	Previous studies have revealed that high levels of serum homocysteine (Hcy) are closely associated with the development of juvenile and age-related cataracts. An increased concentration of Hcy is likely to induce gene specific demethylation in DNA promoter regions. The aim of the present study was to prevent this demethylation by administering acetyl-l-carnitine (ALCAR) to human lens epithelial cells (HLECs). Different concentrations of Hcy were used to treat HLECs for 3, 6, 12 and 24 h and the findings were used to determine the optimum dose to induce endoplasmic reticulum (ER) stress. Similarly, the concentration of ALCAR was standardized. The production of reactive oxygen species (ROS) and the percentage of cells undergoing cell death were measured. The levels of antioxidants, ER stress-associated proteins, mRNA levels of nuclear factor erythroid-2-related factor 2 (Nrf2), Kelch-like ECH-associated protein 1 (Keap1) and promoter DNA methylation of the Keap1 gene were also assessed. Hcy was observed to induce ER stress, produce ROS and lead to cell death. However, administration of ALCAR prevented these effects to a significant degree. Additionally, western blot analysis revealed that ALCAR increased the levels of antioxidant proteins, including catalase, superoxide dismutase, glutathione peroxidase, Nrf2, Keap1 and glutathione. Similarly, the reverse transcription-quantitative polymerase chain reaction experiments on Nrf2 and Keap1, as well as the bisulfite genomic DNA sequencing analysis revealed a preventive effect of ALCAR against Hcy-induced ER stress. The ER stress-induced activation of the unfolded protein response is responsible for demethylation of Keap1 promoter DNA to activate the expression of the Keap1 protein, which then increases the targeting of Nrf2 for proteosomal degradation. This decrease in Nrf2 activity represses the transcription of numerous antioxidant enzyme genes and alters the redox-balance towards lens oxidation. However, treatment with ALCAR led to significant protection from these effects. The present results suggested that ALCAR either prevents or ameliorates the actions of the antioxidant system in HLECs at the level of the protein and the gene. Further advanced studies are required for the development of ALCAR as an anti-cataract agent.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	1
Volume Number	12
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-07-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Acetylcarnitine Pharmacology Antioxidants Homocysteine Antagonists & Inhibitors Intracellular Signaling Peptides And Proteins Genetics Lens, Crystalline Drug Effects Nf-e2-related Factor 2 Animals Catalase Metabolism Cell Death Cell Line Dna Methylation Endoplasmic Reticulum Stress Epigenesis, Genetic Glutathione Glutathione Peroxidase Agonists Cytology Oxidative Stress Promoter Regions, Genetic Proteasome Endopeptidase Complex Proteolysis Reactive Oxygen Species Signal Transduction Superoxide Dismutase Transcription, Genetic Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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