NDLI: Overexpression of Tyro3 receptor tyrosine kinase leads to the acquisition of taxol resistance in ovarian cancer cells.

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Nodal activates smad and extracellular signal-regulated kinases 1/2 pathways promoting renal cell carcinoma proliferation.

Ischemic postconditioning inhibits apoptosis in an in vitro proximal tubular cell model.

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Regulation of the expression of claudin 23 by the enhancer of zeste 2 polycomb group protein in colorectal cancer.

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Ribonucleotide reductase M2 subunit expression and prognostic value in nasopharyngeal carcinoma.

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Synergistic hepatotoxicity by cadmium and chlorpyrifos: disordered hepatic lipid homeostasis.

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Antioxidant activity is required for the protective effects of cyclophilin A against oxidative stress.

MicroRNA-125b is involved in atherosclerosis obliterans in vitro by targeting podocalyxin.

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Correlation between the expression of DNMT1, and GSTP1 and APC, and the methylation status of GSTP1 and APC in association with their clinical significance in prostate cancer.

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Molecular mechanism underlying the anticancer effect of simvastatin on MDA-MB-231 human breast cancer cells.

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B-cell lymphoma 2 and ß-catenin expression in colorectal cancer and their prognostic role following surgery.

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Identification of a mutation in the WISP3 gene in three unrelated families with progressive pseudorheumatoid dysplasia.

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Effects of RNA interference-mediated NRP-1 silencing on the proliferation and apoptosis of breast cancer cells.

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Protective and reversal effects of conserved dopamine neurotrophic factor on PC12 cells following 6-hydroxydopamine administration.

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Deregulated microRNA species in the plasma and placenta of patients with preeclampsia.

Synergistic effects of combined treatment with simvastatin and exemestane on MCF-7 human breast cancer cells.

Ginsenoside Rg3 sensitizes human non-small cell lung cancer cells to Î³-radiation by targeting the nuclear factor-κB pathway.

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N-acetylcysteine treatment following spinal cord trauma reduces neural tissue damage and improves locomotor function in mice.

Use of the disulfiram/copper complex for breast cancer chemoprevention in MMTV-erbB2 transgenic mice.

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Afzelin attenuates asthma phenotypes by downregulation of GATA3 in a murine model of asthma.

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Basic fibroblast growth factor lentiviral vector-transfected sheep bone marrow mesenchymal stem cells and non-specific osteogenic gene expression.

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Activation of the unfolded protein response in aged human lenses.

Conditioned medium from umbilical cord mesenchymal stem cells induces migration and angiogenesis

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Evaluation of the effects of Angelicae dahuricae radix on the morphology and viability of mesenchymal stem cells.

Indepth mapping of human testicular and epididymal proteins and their functional association with spermatozoa.

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Effects of glucose-dependent insulinotropic polypeptide receptor knockout and a high-fat diet on cognitive function and hippocampal gene expression in mice.

Identification and function analysis of contrary genes in Dupuytren's contracture.

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Clinicopathological significance of cytoplasmic transducer of ErbB2. 1 expression in gastric cancer.

Positive and negative regulators of the metallothionein gene (review).

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Lipid metabolism disorders and bone dysfunction--interrelated and mutually regulated (review).

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High-mobility group nucleosome-binding domain 2 protein inhibits the invasion of Klebsiella pneumoniae into mouse lungs in vivo.

Roles of lipoxin A4 receptor activation and anti-interleukin-1ß antibody on the toll-like receptor 2/mycloid differentiation factor 88/nuclear factor-κB pathway in airway inflammation induced by ovalbumin.

Protein identification from dried nipple aspirate fluid on Guthrie cards using mass spectrometry.

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Effects of pinacidil on changes to the microenvironment around the incision site, of a skin/muscle incision and retraction, in a rat model of postoperative pain.

Mutations in PTF1A are not a common cause for human VATER/VACTERL association or neural tube defects mirroring Danforth's short tail mouse.

Implication of microRNA regulation in para-phenylenediamine-induced cell death and senescence in normal human hair dermal papilla cells.

Ehlers-Danlos syndrome type IV is associated with a novel G984R COL3A1 mutation.

Verifying the markers of ovarian cancer using RNA-seq data.

Acetyl-l-carnitine prevents homocysteine-induced suppression of Nrf2/Keap1 mediated antioxidation in human lens epithelial cells.

MicroRNA-423-5p targets O-GlcNAc transferase to induce apoptosis in cardiomyocytes.

Overexpression of N-myc downstream-regulated gene 1 inhibits human glioma proliferation and invasion via phosphoinositide 3-kinase/AKT pathways.

Somatic mutations in myeloid cell leukemia-1 contribute to the pathogenesis of glioma by prolonging its half-life.

Curcuma zedoaria (Berg.) Rosc. essential oil and paclitaxel synergistically enhance the apoptosis of SKOV3 cells.

Somatostatin prevents lipopolysaccharide-induced neurodegeneration in the rat substantia nigra by inhibiting the activation of microglia.

Expression signatures of long non-coding RNAs in early brain injury following experimental subarachnoid hemorrhage.

Nitrogen permease regulator-like 2 enhances sensitivity to oxaliplatin in colon cancer cells.

Emerging role of microRNA-27a in human malignant glioma cell survival via targeting of prohibitin.

Spindle cell oncocytoma of the adenohypophysis: two case reports and a review of the literature.

RNAi-mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo.

Analysis of the microRNA expression profile of normal human dermal papilla cells treated with 5 -dihydrotestosterone.

Apoptosis induced by sonodynamic therapy in human osteosarcoma cells in vitro.

Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray.

Carbamylated low-density lipoprotein attenuates glucose uptake via a nitric oxide-mediated pathway in rat L6 skeletal muscle cells.

Enterovirus 71 induces apoptosis of SHSY5Y human neuroblastoma cells through stimulation of endogenous microRNA let-7b expression.

Generation of transgenic fibroblasts producing doxycycline-inducible human interferon- or erythropoietin for a bovine mammary bioreactor.

Angiotensin-(1-7) stimulates cholesterol efflux from angiotensin II-treated cholesterol-loaded THP-1 macrophages through the suppression of p38 and c-Jun N-terminal kinase signaling.

Trop2 inhibition suppresses the proliferation and invasion of laryngeal carcinoma cells via the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway.

Extracts of Scutellariae Radix inhibit low-density lipoprotein oxidation and the lipopolysaccharide-induced macrophage inflammatory response.

Resveratrol suppresses vascular endothelial growth factor secretion via inhibition of CXC-chemokine receptor 4 expression in ARPE-19 cells.

Upregulation of microRNA-492 induced by epigenetic drug treatment inhibits the malignant phenotype of clear cell renal cell carcinoma in vitro.

Overexpression of Tyro3 receptor tyrosine kinase leads to the acquisition of taxol resistance in ovarian cancer cells.

Cbl participates in shikonin-induced apoptosis by negatively regulating phosphoinositide 3-kinase/protein kinase B signaling.

Apoptosis of HL-60 human leukemia cells induced by Asiatic acid through modulation of B-cell lymphoma 2 family proteins and the mitogen-activated protein kinase signaling pathway.

Epigenetic modification and preliminary investigation of the mechanism of the immune evasion of HL-60 cells.

Vaccarin promotes endothelial cell proliferation in association with neovascularization in vitro and in vivo.

Synergistic effects of valproic acid and arsenic trioxide on RPMI8226 cells in vitro and the possible underlying mechanisms.

Litsea japonica extract inhibits neuronal apoptosis and the accumulation of advanced glycation end products in the diabetic mouse retina.

Effects of OsteoKing on osteoporotic rabbits.

Anti-inflammatory effects of Gualou Guizhi decoction in transient focal cerebral ischemic brains. [Corrected].

Sevoflurane ameliorates intestinal ischemia-reperfusion-induced lung injury by inhibiting the synergistic action between mast cell activation and oxidative stress.

Antibody microarray profiling of osteosarcoma cell serum for identifying potential biomarkers.

Upregulated microRNA-16 as an oncogene in renal cell carcinoma.

A novel molecular probe 131I-K237 targeting tumor angiogenesis in human prostate cancer xenografts.

Association study of polymorphisms in interferon-Î³ receptor genes with the risk of pulmonary tuberculosis.

Effects of cinobufacini injection on cell proliferation and the expression of topoisomerases in human HepG-2 hepatocellular carcinoma cells.

Effects of silencing the ATP-binding cassette protein E1 gene by electroporation on the proliferation and migration of EC109 human esophageal cancer cells.

Differentiation of human umbilical cord mesenchymal stem cells into germ-like cells in mouse seminiferous tubules.

Ser49Gly polymorphism in the ß-adrenergic receptor 1 gene in a population sample from Rio de Janeiro state, Brazil, stratified by self-identified skin color and genetic ancestry.

Blood-brain barrier permeability of Gualou Guizhi granules and neuroprotective effects in ischemia/reperfusion injury.

MicroRNA-21 promotes osteogenic differentiation by targeting small mothers against decapentaplegic 7.

DNA-dependent protein kinase catalytic subunit inhibitor reverses acquired radioresistance in lung adenocarcinoma by suppressing DNA repair.

MicroRNA-133a inhibits proliferation and invasion, and induces apoptosis in gastric carcinoma cells via targeting fascin actin-bundling protein 1.

Modulatory role of resveratrol on cytotoxic activity of cisplatin, sensitization and modification of cisplatin resistance in colorectal cancer cells.

Resveratrol analog piceatannol restores the palmitic acid-induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti-inflammatory and antioxidative heme oxygenase-1 in human endothelial cells.

Tumor necrosis factor-like weak inducer of apoptosis regulates particle-induced inflammatory osteolysis via the p38 mitogen-activated protein kinase signaling pathway.

Connective tissue growth factor stimulates the proliferation, migration and differentiation of lung fibroblasts during paraquat-induced pulmonary fibrosis.

Fetuin-A 742 (C/T) and 766 (C/G) polymorphic sites are associated with increased risk of myocardial infarction in older patients (≥ 40 years of age).

Identification of active ingredients in Wuzhuyu decoction improving migraine in mice by spectral efficiency association.

MicroRNA-509-3p inhibits cancer cell proliferation and migration by targeting the mitogen-activated protein kinase kinase kinase 8 oncogene in renal cell carcinoma.

cDNA microarray analysis of the effect of cantharidin on DNA damage, cell cycle and apoptosis-associated gene expression in NCI-H460 human lung cancer cells in vitro.

Gene expression changes in human mesenchymal stem cells from patients with osteoporosis.

Identification of KRAS and PIK3CA but not BRAF mutations in patients with gastric cancer.

Serum microRNA-125a-5p, a useful biomarker in liver diseases, correlates with disease progression.

High glucose promotes gastric cancer chemoresistance in vivo and in vitro.

Antineoplastic effect of a novel chemopreventive agent, neokestose, on the Caco-2 cell line via inhibition of expression of nuclear factor-κB and cyclooxygenase-2.

Upregulated microRNA-214 enhances cardiac injury by targeting ITCH during coxsackievirus infection.

Ameliorative effects of Gualou Guizhi decoction on inflammation in focal cerebral ischemic-reperfusion injury.

DNA methyltransferase 3, a target of microRNA-29c, contributes to neuronal proliferation by regulating the expression of brain-derived neurotrophic factor.

Association of neonatal necrotizing enterocolitis with myeloid differentiation-2 and GM2 activator protein genetic polymorphisms.

Comparative analysis of the influence of Fructus Ligustri Lucidi on a rat lumbar disc herniation model.

3,3'-Diindolylmethane attenuates cardiac H9c2 cell hypertrophy through 5'-adenosine monophosphate-activated protein kinase- .

Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2 .

Agmatine protects Müller cells from high-concentration glucose-induced cell damage via N-methyl-D-aspartic acid receptor inhibition.

Efficient labeling in vitro with non-ionic gadolinium magnetic resonance imaging contrast agent and fluorescent transfection agent in bone marrow stromal cells of neonatal rats.

MicroRNA-218 and microRNA-520a inhibit cell proliferation by downregulating E2F2 in hepatocellular carcinoma.

Anti-profibrotic effects of artesunate on bleomycin-induced pulmonary fibrosis in Sprague Dawley rats.

Computational networks of activating transcription factor 3 gene in Huh7 cell lines and hepatitis C virus-infected Huh7 cell lines.

Gliotoxin potentiates osteoblast differentiation by inhibiting nuclear factor-κB signaling.

VP22 mediates intercellular trafficking and enhances the in vitro antitumor activity of PTEN.

Ophiopogonin-D suppresses MDA-MB-435 cell adhesion and invasion by inhibiting matrix metalloproteinase-9.

Ischemic postconditioning regulates cardiomyocyte autophagic activity following ischemia/reperfusion injury.

Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo.

Apoptin-modified human mesenchymal stem cells inhibit growth of lung carcinoma in nude mice.

Knockdown of ubiquitin protein ligase E3A affects proliferation and invasion, and induces apoptosis of breast cancer cells through regulation of annexin A2.

Violacein induces p44/42 mitogen-activated protein kinase-mediated solid tumor cell death and inhibits tumor cell migration.

Regulation of the oncogenic function of distal-less 4 by microRNA-122 in hepatocellular carcinoma.

Calcitriol ameliorates renal damage in a pre-established proteinuria model.

Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme oxygenase-1.

An integrated analysis of the effects of microRNA and mRNA on esophageal squamous cell carcinoma

Arsenic trioxide inhibits breast cancer cell growth via microRNA-328/hERG pathway in MCF-7 cells.

Social defeat stress promotes tumor growth and angiogenesis by upregulating vascular endothelial growth factor/extracellular signal-regulated kinase/matrix metalloproteinase signaling in a mouse model of lung carcinoma.

Transforming growth factor-ß, insulin-like growth factor I/insulin-like growth factor I receptor and vascular endothelial growth factor-A: prognostic and predictive markers in triple-negative and non-triple-negative breast cancer.

Design, expression and characterization of single chain Fv, Mms13 and the single chain Fvmms13 fusion protein.

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Overexpression of Tyro3 receptor tyrosine kinase leads to the acquisition of taxol resistance in ovarian cancer cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lee, Chuhee
Description	Author Affiliation: Lee C ( Department of Biochemistry and Molecular Biology, School of Medicine, Yeungnam University, Daegu 705717, Republic of Korea.)
Abstract	The majority of patients with ovarian cancer are diagnosed at the advanced stages (III/IV) and their 5-year-survival rate is relatively low. One of the major causes of the poor prognosis of ovarian cancer is the development of resistance to first-line chemotherapy, including platinum and taxol. Therefore, improvements in current understanding of chemoresistance is required for the successful treatment of ovarian cancer. In the present study, taxol-resistant ovarian cancer cells, SKOV3/TR, were established by exposing parental SKOV3 cells to increasing concentrations of taxol. . Briefly, cells were treated with 1.5 nM (for 4 weeks), 3 nM (for 4 weeks), 6 nM (for 5 weeks), 12 nM (for 5 weeks) and 24 nM taxol (for 8 weeks) over 6 months. The SKOV3/TR cells were found to be smaller in size and rounder in shape compared with their parental cells. Cell viability and colony formation assays demonstrated an increase in the population doubling time of the SKOV3/TR cells, indicating a reduction in the proliferative capacity of these cells. Reverse transcription-polymerase chain reaction and western blot analysis revealed that, among the TAM receptor tyrosine kinases (RTKs), the mRNA and protein expression levels of Tyro3 RTK were increased, while those of Axl and Mer RTK were decreased in the SKOV3/TR cells. In addition, restoration of the level of Tyro3 by transfecting Tyro3-specific small interfering RNA into the SKOV3/TR cells reduced the proliferative capacity of the cells, indicating that upregulation of the expression of Tyro3 in SKOV3/TR cells may promote survival in the presence of taxol, which eventually resulted in the acquisition of resistance upon taxol treatment. The present study subsequently found that, in the SKOV3/TR cells, the level of intracellular reactive oxygen species (ROS) was elevated, and antioxidant treatment with N-acetyl cysteine (NAC) exerted more profound antiproliferative effects compared with the parental cells. The western blot analysis demonstrated that treatment of the SKOV3/TR cells with NAC reduced the protein expression of Tyro3, and the inhibitory effect of NAC on the phosphorylation of Akt was increased, which may have had a positive effect on the proliferation of the SKOV3/TR cells. The levels of phosphorylation and protein expression of signal transducers and activators of transcription 3 (STAT3) were not affected by NAC treatment, indicating that the phosphorylation of Akt, but not expression or phosphorylation of STAT3, was associated with the increased intracellular ROS level in the SKOV3/TR cells. Taken together, the results of the present study demonstrated that the acquired taxol resistance of ovarian cancer cells was associated with ROS-dependent upregulation in the expression of Tyro3 RTK and the subsequent activation of Akt.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	1
Volume Number	12
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-07-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Oncogene Protein V-akt Biosynthesis Ovarian Neoplasms Drug Therapy Paclitaxel Administration & Dosage Receptor Protein-tyrosine Kinases Acetylcysteine Cell Line, Tumor Drug Resistance, Neoplasm Drug Effects Gene Expression Regulation, Neoplastic Genetics Pathology Phosphorylation Rna, Messenger Signal Transduction Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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