NDLI: High-dose insulin inhibits gap junction intercellular communication in vascular smooth muscle cells.

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Nodal activates smad and extracellular signal-regulated kinases 1/2 pathways promoting renal cell carcinoma proliferation.

Ischemic postconditioning inhibits apoptosis in an in vitro proximal tubular cell model.

Overexpression of adenosine deaminase acting on RNA 1 in chordoma tissues is associated with chordoma pathogenesis by reducing miR125a and miR10a expression.

Inhibitory effect of receptor for advanced glycation end productspecific small interfering RNAs on the development of hepatic fibrosis in primary rat hepatic stellate cells.

Synergistic effects of oxyresveratrol in conjunction with antibiotics against methicillin-resistant Staphylococcus aureus.

Downregulation of the expression of Bcell lymphoma-extra large by RNA interference induces apoptosis and enhances the radiosensitivity of nonsmall cell lung cancer cells.

Impact of tissue type and content of neoplastic cells of samples on the quality of epidermal growth factor receptor mutation analysis among patients with lung adenocarcinoma.

Impact of Brachyury on epithelial-mesenchymal transitions and chemosensitivity in non-small cell lung cancer.

Interleukin-4 affects the mature phenotype and function of rat bone marrow-derived dendritic cells.

Osteogenic cell fractions isolated from mouse tongue muscle.

-Lipoic acid protects against hypoxia/reoxygenation-induced injury in human umbilical vein endothelial cells through suppression of apoptosis and autophagy.

Ubiquitin-modified hepatitis B virus core antigen effectively facilitates antigen presentation and enhances cytotoxic T lymphocyte activity via the cytoplasmic transduction peptide in vitro.

Transforming growth factor-ß inhibits IQ motif containing guanosine triphosphatase activating protein 1 expression in lung fibroblasts via the nuclear factor-κB signaling pathway.

Inhibitory effects of autologous Î³-irradiated cell conditioned medium on osteoblasts in vitro.

Synergistic combination of histone deacetylase inhibitor suberoylanilide hydroxamic acid and oncolytic adenovirus ZD55-TRAIL as a therapy against cervical cancer.

Chemoresistance to doxorubicin induces epithelial-mesenchymal transition via upregulation of transforming growth factor ß signaling in HCT116 colon cancer cells.

Repression of metadherin inhibits biological behavior of prostate cancer cells and enhances their sensitivity to cisplatin.

Role of p53ß in the inhibition of proliferation of gastric cancer cells expressing wild-type or mutated p53.

FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7.

Regulation of the expression of claudin 23 by the enhancer of zeste 2 polycomb group protein in colorectal cancer.

Expression of the platelet-activating factor receptor enhances benzyl isothiocyanate-induced apoptosis in murine and human melanoma cells

Screening for characteristic microRNAs between pre-invasive and invasive stages of cervical cancer.

Inhibition of livin expression suppresses cell proliferation and enhances chemosensitivity to cisplatin in human lung adenocarcinoma cells.

Prenatal nicotine exposure induces gender-associated left ventricular-arterial uncoupling in adult offspring.

Expression of integrin-binding protein Nischarin in metastatic breast cancer.

Lentivirus-mediated knockdown of rhomboid domain containing 1 inhibits colorectal cancer cell growth.

Estrogen receptorß2 regulates interlukin-12 receptorß2 expression via p38 mitogen-activated protein kinase signaling and inhibits non-small-cell lung cancer proliferation and invasion.

Vasoactive intestinal peptide induces CD14+HLA-DR/low myeloid-derived suppressor cells in gastric cancer.

Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis.

Monocyte chemotactic protein-1 promotes the proliferation and invasion of osteosarcoma cells and upregulates the expression of AKT.

Klotho gene delivery ameliorates renal hypertrophy and fibrosis in streptozotocin-induced diabetic rats by suppressing the Rho-associated coiled-coil kinase signaling pathway.

Thymosin ß4 promotes hepatoblastoma metastasis via the induction of epithelial-mesenchymal transition.

MicroRNA-183/182/96 cooperatively regulates the proliferation of colon cancer cells.

SOCS3 blocks HIF-1α expression to inhibit proliferation and angiogenesis of human small cell lung cancer by downregulating activation of Akt, but not STAT3

Icariin recovers the osteogenic differentiation and bone formation of bone marrow stromal cells from a rat model of estrogen deficiency-induced osteoporosis.

Ribonucleotide reductase M2 subunit expression and prognostic value in nasopharyngeal carcinoma.

Inhibition of autophagy by 3-methyladenine potentiates sulforaphane-induced cell death of BE(2)-C human neuroblastoma cells.

Plasma sphingolipids: potential biomarkers for severe hepatic fibrosis in chronic hepatitis C.

Activation of notch signaling mediates the induction and maintenance of mechanical allodynia in a rat model of neuropathic pain.

Simultaneous silencing of XIAP and survivin causes partial mesenchymal-epithelial transition of human pancreatic cancer cells via the PTEN/PI3K/Akt pathway.

Synergistic hepatotoxicity by cadmium and chlorpyrifos: disordered hepatic lipid homeostasis.

Ligustrazine attenuates the platelet-derived growth factor-BB-induced proliferation and migration of vascular smooth muscle cells by interrupting extracellular signal-regulated kinase and P38 mitogen-activated protein kinase pathways.

Immune-enhancing effect of nano-DNA vaccine encoding a gene of the prME protein of Japanese encephalitis virus and BALB/c mouse granulocyte-macrophage colony-stimulating factor.

Identification and validation of reference genes for the detection of serum microRNAs by reverse transcription-quantitative polymerase chain reaction in patients with bladder cancer.

Testosterone enhances lipopolysaccharide-induced interleukin-6 and macrophage chemotactic protein-1 expression by activating the extracellular signal-regulated kinase 1/2/nuclear factor-κB signalling pathways in 3T3-L1 adipocytes.

Association of genetic polymorphisms in the telomerase reverse transcriptase gene with prostate cancer aggressiveness.

Antioxidant activity is required for the protective effects of cyclophilin A against oxidative stress.

MicroRNA-125b is involved in atherosclerosis obliterans in vitro by targeting podocalyxin.

Combination of cytokinin and auxin induces apoptosis, cell cycle progression arrest and blockage of the Akt pathway in HeLa cells.

Correlation between the expression of DNMT1, and GSTP1 and APC, and the methylation status of GSTP1 and APC in association with their clinical significance in prostate cancer.

Cluster of differentiation 147 is a key molecule during hepatocellular carcinoma cell-hepatic stellate cell cross-talk in the rat liver.

Molecular mechanism underlying the anticancer effect of simvastatin on MDA-MB-231 human breast cancer cells.

Short hairpin RNA targeting AKT1 and PI3K/p85 suppresses the proliferation and self-renewal of lung cancer stem cells.

B-cell lymphoma 2 and ß-catenin expression in colorectal cancer and their prognostic role following surgery.

Co-culture with bone marrow stromal cells protects PC12 neuronal cells from tumor necrosis factor- -induced apoptosis by inhibiting the tumor necrosis factor receptor/caspase signaling pathway.

Identification of a mutation in the WISP3 gene in three unrelated families with progressive pseudorheumatoid dysplasia.

Estrogen receptor mediates the effects of notoginsenoside R1 on endotoxin-induced inflammatory and apoptotic responses in H9c2 cardiomyocytes.

Pirfenidone inhibits proliferation, arrests the cell cycle, and downregulates heat shock protein-47 and collagen type I in rat hepatic stellate cells in vitro.

Trophoblast glycoprotein promotes pancreatic ductal adenocarcinoma cell metastasis through Wnt/planar cell polarity signaling.

Circulating microRNA-196a as a candidate diagnostic biomarker for chronic hepatitis C.

A subset of circulating microRNAs is expressed differently in patients with myocardial infarction.

A disintegrin and metalloprotease 17 promotes microglial cell survival via epidermal growth factor receptor signalling following spinal cord injury.

Apogossypolone induces reactive oxygen species accumulation and controls cell cycle progression in Raji Burkkit's lymphoma cells.

All-trans-retinoic acid inhibits chondrogenesis of rat embryo hindlimb bud mesenchymal cells by downregulating p53 expression.

Overexpression of caudal type homeobox transcription factor 2 inhibits the growth of the MGC-803 human gastric cancer cell line in vivo.

Optimized codon usage enhances the expression and immunogenicity of DNA vaccine encoding Taenia solium oncosphere TSOL18 gene.

Effects of RNA interference-mediated NRP-1 silencing on the proliferation and apoptosis of breast cancer cells.

Protective mechanism of Korean Red Ginseng in cisplatin-induced ototoxicity through attenuation of nuclear factor-κB and caspase-1 activation.

Protective and reversal effects of conserved dopamine neurotrophic factor on PC12 cells following 6-hydroxydopamine administration.

Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer's disease (review).

Deregulated microRNA species in the plasma and placenta of patients with preeclampsia.

Synergistic effects of combined treatment with simvastatin and exemestane on MCF-7 human breast cancer cells.

Ginsenoside Rg3 sensitizes human non-small cell lung cancer cells to Î³-radiation by targeting the nuclear factor-κB pathway.

Downregulation of matrix metalloproteinase 9 by small interfering RNA inhibits the tumor growth of ovarian epithelial carcinoma in vitro and in vivo.

Immunohistochemical profile of cytokines and growth factors expressed in vestibular schwannoma and in normal vestibular nerve tissue.

Recombinant receptor activator of nuclear factor κB exhibits more marked inhibitory effects on osteoclasts compared with recombinant osteoprotegerin in vitro and in vivo.

N-acetylcysteine treatment following spinal cord trauma reduces neural tissue damage and improves locomotor function in mice.

Use of the disulfiram/copper complex for breast cancer chemoprevention in MMTV-erbB2 transgenic mice.

MicroRNA-21, induced by high glucose, modulates macrophage apoptosis via programmed cell death 4.

Metastasis-associated in colon cancer-1 is associated with poor prognosis in hepatocellular carcinoma, partly by promoting proliferation through enhanced glucose metabolism.

Protective role of isoflurane pretreatment in rats with focal cerebral ischemia and the underlying molecular mechanism.

Afzelin attenuates asthma phenotypes by downregulation of GATA3 in a murine model of asthma.

Antiproliferative effects of anastrozole on MCF-7 human breast cancer cells in vitro are significantly enhanced by combined treatment with testosterone undecanoate.

Basic fibroblast growth factor lentiviral vector-transfected sheep bone marrow mesenchymal stem cells and non-specific osteogenic gene expression.

A pleiotropic effect of the single clustered hepatic metastamiRs miR-96-5p and miR-182-5p on insulin-like growth factor II, insulin-like growth factor-1 receptor and insulin-like growth factor-binding protein-3 in hepatocellular carcinoma.

Activation of the unfolded protein response in aged human lenses.

Conditioned medium from umbilical cord mesenchymal stem cells induces migration and angiogenesis

Effect of astragaloside IV against rat myocardial cell apoptosis induced by oxidative stress via mitochondrial ATP-sensitive potassium channels.

Attenuation of enoyl coenzyme A hydratase 1 expression in colorectal cancer cells using small interfering RNA inhibits cell proliferation and migration.

Dicaine represses apoptosis-linked gene 2-interacting protein X expression to induce airway epithelial barrier dysfunction.

Interleukin-1ß induced nuclear factor-κB binds to a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 promoter in human chondrosarcoma cells.

CD9 modulates proliferation of human glioblastoma cells via epidermal growth factor receptor signaling.

Golgi phosphoprotein 3 expression predicts poor prognosis in patients with prostate cancer undergoing radical prostatectomy.

Overexpression of serine/threonine-protein kinase-1 in pancreatic cancer tissue: Serine/threonine-protein kinase-1 knockdown increases the chemosensitivity of pancreatic cancer cells.

B-crystallin reduces ristocetininduced soluble CD40 ligand release in human platelets: suppression of thromboxane A2 generation.

Integrated microRNA-mRNA analysis revealing the potential roles of microRNAs in tongue squamous cell cancer.

Evaluation of the effects of Angelicae dahuricae radix on the morphology and viability of mesenchymal stem cells.

Indepth mapping of human testicular and epididymal proteins and their functional association with spermatozoa.

Paclitaxel resistance in MCF-7/PTX cells is reversed by paeonol through suppression of the SET/phosphatidylinositol 3-kinase/Akt pathway.

Arg972 insulin receptor substrate-1 enhances tumor necrosis factor- -induced apoptosis in osteoblasts.

Metformin alleviates high glucose-mediated oxidative stress in rat glomerular mesangial cells by modulation of p38 mitogen-activated protein kinase expression in vitro.

A patient with unusual features and a 69.5 Mb duplication from a de novo extra der (9): a case report.

Inhibition of Forkhead box protein M1 by thiostrepton increases chemosensitivity to doxorubicin in T-cell acute lymphoblastic leukemia.

Effects of glucose-dependent insulinotropic polypeptide receptor knockout and a high-fat diet on cognitive function and hippocampal gene expression in mice.

Identification and function analysis of contrary genes in Dupuytren's contracture.

High-dose insulin inhibits gap junction intercellular communication in vascular smooth muscle cells.

Beneficial effects of tripterygium glycosides tablet on biomarkers in patients with ankylosing spondylitis.

Clinicopathological significance of cytoplasmic transducer of ErbB2. 1 expression in gastric cancer.

Positive and negative regulators of the metallothionein gene (review).

Angiotensin II promotes melanogenesis via angiotensin II type 1 receptors in human melanocytes.

All-trans retinoic acid impairs the vasculogenic mimicry formation ability of U87 stem-like cells through promoting differentiation.

Orostachys japonicus inhibits the expression of MMP-2 and MMP-9 mRNA and modulates the expression of iNOS and COX-2 genes in human PMA-differentiated THP-1 cells via inhibition of NF-κB and MAPK activation.

RNA silencing of integrin-linked kinase increases the sensitivity of the A549 lung cancer cell line to cisplatin and promotes its apoptosis.

Inhibition of the JAK2/STAT3 signaling pathway exerts a therapeutic effect on osteosarcoma.

Curcumin triggers apoptosis via upregulation of Bax/Bcl-2 ratio and caspase activation in SW872 human adipocytes.

MicroRNA-146b-5p inhibits the growth of gallbladder carcinoma by targeting epidermal growth factor receptor.

Lipid metabolism disorders and bone dysfunction--interrelated and mutually regulated (review).

Mycobacteriophages: an important tool for the diagnosis of Mycobacterium tuberculosis (review).

Serum pentraxin 3 is a novel marker in Crohn's disease.

Investigating polymorphisms in membrane-associated transporter protein SLC45A2, using sucrose transporters as a model.

Fully human HER2/cluster of differentiation 3 bispecific antibody triggers potent and specific cytotoxicity of T lymphocytes against breast cancer.

Bioinformatics analysis of abnormal DNA methylation in muscle samples from monozygotic twins discordant for type 2 diabetes.

Zanthoxylum schinifolium leaf ethanol extract inhibits adipocyte differentiation through inactivation of the extracellular signal regulated kinase and phosphoinositide 3-kinase/Akt signaling pathways in 3T3-L1 pre-adipocytes.

A novel endoglin mutation in hereditary hemorrhagic telangiectasia type 1: a case report.

Estimation of the environmental effect of natural volatile organic compounds from Chamaecyparis obtusa and their effect on atopic dermatitis-like skin lesions in mice.

Enoyl-coenzyme A hydratase short chain 1 silencing attenuates the proliferation of hepatocellular carcinoma by inhibiting epidermal growth factor signaling in vitro and in vivo.

High-mobility group nucleosome-binding domain 2 protein inhibits the invasion of Klebsiella pneumoniae into mouse lungs in vivo.

Roles of lipoxin A4 receptor activation and anti-interleukin-1ß antibody on the toll-like receptor 2/mycloid differentiation factor 88/nuclear factor-κB pathway in airway inflammation induced by ovalbumin.

Protein identification from dried nipple aspirate fluid on Guthrie cards using mass spectrometry.

Chitosan oligosaccharides in combination with Agaricus blazei Murill extract reduces hepatoma formation in mice with severe combined immunodeficiency.

Effects of pinacidil on changes to the microenvironment around the incision site, of a skin/muscle incision and retraction, in a rat model of postoperative pain.

Mutations in PTF1A are not a common cause for human VATER/VACTERL association or neural tube defects mirroring Danforth's short tail mouse.

Implication of microRNA regulation in para-phenylenediamine-induced cell death and senescence in normal human hair dermal papilla cells.

Ehlers-Danlos syndrome type IV is associated with a novel G984R COL3A1 mutation.

Verifying the markers of ovarian cancer using RNA-seq data.

Acetyl-l-carnitine prevents homocysteine-induced suppression of Nrf2/Keap1 mediated antioxidation in human lens epithelial cells.

MicroRNA-423-5p targets O-GlcNAc transferase to induce apoptosis in cardiomyocytes.

Overexpression of N-myc downstream-regulated gene 1 inhibits human glioma proliferation and invasion via phosphoinositide 3-kinase/AKT pathways.

Somatic mutations in myeloid cell leukemia-1 contribute to the pathogenesis of glioma by prolonging its half-life.

Curcuma zedoaria (Berg.) Rosc. essential oil and paclitaxel synergistically enhance the apoptosis of SKOV3 cells.

Somatostatin prevents lipopolysaccharide-induced neurodegeneration in the rat substantia nigra by inhibiting the activation of microglia.

Expression signatures of long non-coding RNAs in early brain injury following experimental subarachnoid hemorrhage.

Nitrogen permease regulator-like 2 enhances sensitivity to oxaliplatin in colon cancer cells.

Emerging role of microRNA-27a in human malignant glioma cell survival via targeting of prohibitin.

Spindle cell oncocytoma of the adenohypophysis: two case reports and a review of the literature.

RNAi-mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo.

Analysis of the microRNA expression profile of normal human dermal papilla cells treated with 5 -dihydrotestosterone.

Apoptosis induced by sonodynamic therapy in human osteosarcoma cells in vitro.

Identification of biomarkers regulated by rexinoids (LGD1069, LG100268 and Ro25-7386) in human breast cells using Affymetrix microarray.

Carbamylated low-density lipoprotein attenuates glucose uptake via a nitric oxide-mediated pathway in rat L6 skeletal muscle cells.

Enterovirus 71 induces apoptosis of SHSY5Y human neuroblastoma cells through stimulation of endogenous microRNA let-7b expression.

Generation of transgenic fibroblasts producing doxycycline-inducible human interferon- or erythropoietin for a bovine mammary bioreactor.

Angiotensin-(1-7) stimulates cholesterol efflux from angiotensin II-treated cholesterol-loaded THP-1 macrophages through the suppression of p38 and c-Jun N-terminal kinase signaling.

Trop2 inhibition suppresses the proliferation and invasion of laryngeal carcinoma cells via the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway.

Extracts of Scutellariae Radix inhibit low-density lipoprotein oxidation and the lipopolysaccharide-induced macrophage inflammatory response.

Resveratrol suppresses vascular endothelial growth factor secretion via inhibition of CXC-chemokine receptor 4 expression in ARPE-19 cells.

Upregulation of microRNA-492 induced by epigenetic drug treatment inhibits the malignant phenotype of clear cell renal cell carcinoma in vitro.

Overexpression of Tyro3 receptor tyrosine kinase leads to the acquisition of taxol resistance in ovarian cancer cells.

Cbl participates in shikonin-induced apoptosis by negatively regulating phosphoinositide 3-kinase/protein kinase B signaling.

Apoptosis of HL-60 human leukemia cells induced by Asiatic acid through modulation of B-cell lymphoma 2 family proteins and the mitogen-activated protein kinase signaling pathway.

Epigenetic modification and preliminary investigation of the mechanism of the immune evasion of HL-60 cells.

Vaccarin promotes endothelial cell proliferation in association with neovascularization in vitro and in vivo.

Synergistic effects of valproic acid and arsenic trioxide on RPMI8226 cells in vitro and the possible underlying mechanisms.

Litsea japonica extract inhibits neuronal apoptosis and the accumulation of advanced glycation end products in the diabetic mouse retina.

Effects of OsteoKing on osteoporotic rabbits.

Anti-inflammatory effects of Gualou Guizhi decoction in transient focal cerebral ischemic brains. [Corrected].

Sevoflurane ameliorates intestinal ischemia-reperfusion-induced lung injury by inhibiting the synergistic action between mast cell activation and oxidative stress.

Antibody microarray profiling of osteosarcoma cell serum for identifying potential biomarkers.

Upregulated microRNA-16 as an oncogene in renal cell carcinoma.

A novel molecular probe 131I-K237 targeting tumor angiogenesis in human prostate cancer xenografts.

Association study of polymorphisms in interferon-Î³ receptor genes with the risk of pulmonary tuberculosis.

Effects of cinobufacini injection on cell proliferation and the expression of topoisomerases in human HepG-2 hepatocellular carcinoma cells.

Effects of silencing the ATP-binding cassette protein E1 gene by electroporation on the proliferation and migration of EC109 human esophageal cancer cells.

Differentiation of human umbilical cord mesenchymal stem cells into germ-like cells in mouse seminiferous tubules.

Ser49Gly polymorphism in the ß-adrenergic receptor 1 gene in a population sample from Rio de Janeiro state, Brazil, stratified by self-identified skin color and genetic ancestry.

Blood-brain barrier permeability of Gualou Guizhi granules and neuroprotective effects in ischemia/reperfusion injury.

MicroRNA-21 promotes osteogenic differentiation by targeting small mothers against decapentaplegic 7.

DNA-dependent protein kinase catalytic subunit inhibitor reverses acquired radioresistance in lung adenocarcinoma by suppressing DNA repair.

MicroRNA-133a inhibits proliferation and invasion, and induces apoptosis in gastric carcinoma cells via targeting fascin actin-bundling protein 1.

Modulatory role of resveratrol on cytotoxic activity of cisplatin, sensitization and modification of cisplatin resistance in colorectal cancer cells.

Resveratrol analog piceatannol restores the palmitic acid-induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti-inflammatory and antioxidative heme oxygenase-1 in human endothelial cells.

Tumor necrosis factor-like weak inducer of apoptosis regulates particle-induced inflammatory osteolysis via the p38 mitogen-activated protein kinase signaling pathway.

Connective tissue growth factor stimulates the proliferation, migration and differentiation of lung fibroblasts during paraquat-induced pulmonary fibrosis.

Fetuin-A 742 (C/T) and 766 (C/G) polymorphic sites are associated with increased risk of myocardial infarction in older patients (≥ 40 years of age).

Identification of active ingredients in Wuzhuyu decoction improving migraine in mice by spectral efficiency association.

MicroRNA-509-3p inhibits cancer cell proliferation and migration by targeting the mitogen-activated protein kinase kinase kinase 8 oncogene in renal cell carcinoma.

cDNA microarray analysis of the effect of cantharidin on DNA damage, cell cycle and apoptosis-associated gene expression in NCI-H460 human lung cancer cells in vitro.

Gene expression changes in human mesenchymal stem cells from patients with osteoporosis.

Identification of KRAS and PIK3CA but not BRAF mutations in patients with gastric cancer.

Serum microRNA-125a-5p, a useful biomarker in liver diseases, correlates with disease progression.

High glucose promotes gastric cancer chemoresistance in vivo and in vitro.

Antineoplastic effect of a novel chemopreventive agent, neokestose, on the Caco-2 cell line via inhibition of expression of nuclear factor-κB and cyclooxygenase-2.

Upregulated microRNA-214 enhances cardiac injury by targeting ITCH during coxsackievirus infection.

Ameliorative effects of Gualou Guizhi decoction on inflammation in focal cerebral ischemic-reperfusion injury.

DNA methyltransferase 3, a target of microRNA-29c, contributes to neuronal proliferation by regulating the expression of brain-derived neurotrophic factor.

Association of neonatal necrotizing enterocolitis with myeloid differentiation-2 and GM2 activator protein genetic polymorphisms.

Comparative analysis of the influence of Fructus Ligustri Lucidi on a rat lumbar disc herniation model.

3,3'-Diindolylmethane attenuates cardiac H9c2 cell hypertrophy through 5'-adenosine monophosphate-activated protein kinase- .

Salubrinal protects cardiomyocytes against apoptosis in a rat myocardial infarction model via suppressing the dephosphorylation of eukaryotic translation initiation factor 2 .

Agmatine protects Müller cells from high-concentration glucose-induced cell damage via N-methyl-D-aspartic acid receptor inhibition.

Efficient labeling in vitro with non-ionic gadolinium magnetic resonance imaging contrast agent and fluorescent transfection agent in bone marrow stromal cells of neonatal rats.

MicroRNA-218 and microRNA-520a inhibit cell proliferation by downregulating E2F2 in hepatocellular carcinoma.

Anti-profibrotic effects of artesunate on bleomycin-induced pulmonary fibrosis in Sprague Dawley rats.

Computational networks of activating transcription factor 3 gene in Huh7 cell lines and hepatitis C virus-infected Huh7 cell lines.

Gliotoxin potentiates osteoblast differentiation by inhibiting nuclear factor-κB signaling.

VP22 mediates intercellular trafficking and enhances the in vitro antitumor activity of PTEN.

Ophiopogonin-D suppresses MDA-MB-435 cell adhesion and invasion by inhibiting matrix metalloproteinase-9.

Ischemic postconditioning regulates cardiomyocyte autophagic activity following ischemia/reperfusion injury.

Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo.

Apoptin-modified human mesenchymal stem cells inhibit growth of lung carcinoma in nude mice.

Knockdown of ubiquitin protein ligase E3A affects proliferation and invasion, and induces apoptosis of breast cancer cells through regulation of annexin A2.

Violacein induces p44/42 mitogen-activated protein kinase-mediated solid tumor cell death and inhibits tumor cell migration.

Regulation of the oncogenic function of distal-less 4 by microRNA-122 in hepatocellular carcinoma.

Calcitriol ameliorates renal damage in a pre-established proteinuria model.

Curcumin protects renal tubular epithelial cells from high glucose-induced epithelial-to-mesenchymal transition through Nrf2-mediated upregulation of heme oxygenase-1.

An integrated analysis of the effects of microRNA and mRNA on esophageal squamous cell carcinoma

Arsenic trioxide inhibits breast cancer cell growth via microRNA-328/hERG pathway in MCF-7 cells.

Social defeat stress promotes tumor growth and angiogenesis by upregulating vascular endothelial growth factor/extracellular signal-regulated kinase/matrix metalloproteinase signaling in a mouse model of lung carcinoma.

Transforming growth factor-ß, insulin-like growth factor I/insulin-like growth factor I receptor and vascular endothelial growth factor-A: prognostic and predictive markers in triple-negative and non-triple-negative breast cancer.

Design, expression and characterization of single chain Fv, Mms13 and the single chain Fvmms13 fusion protein.

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High-dose insulin inhibits gap junction intercellular communication in vascular smooth muscle cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bian, Ou Sun, Yingxian Zhang, Haishan Guan, Qigang Zeng, Dingyin
Description	Author Affiliation: Bian O ( Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.); Zhang H ( Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.); Guan Q ( Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.); Sun Y ( Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.); Zeng D ( Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.)
Abstract	Gap junction intercellular communication (GJIC) is important in mediating intercellular substance and signal transmission. Connexin (Cx)43 is a major component involved in GJIC in vascular tissue and its abnormal expression is closely associated with various vascular diseases. Insulin resistance is the central component of metabolic syndrome, and high doses of insulin can affect vascular function through multiple pathways, resulting in cardiovascular disease. However, the effects of insulin on GJIC function and connexin (Cx)43 expression in vascular smooth muscle cells (VSMCs) remain unclear. Following treatment of VSMCs with different doses of insulin, a fluorescence recovery after photobleaching (FRAP) assay was performed to evaluate GJIC function in treated VSMCs. The results showed that highdose insulin suppressed GJIC function. Western blot assays further demonstrated that highdose insulin induced the phosphorylation of Cx43 at s368 and downregulated the expression of Cx43. H2O2 release assays demonstrated that highdose insulin treatment significantly elevated the cellular H2O2 level. In addition, compared with cells treated with highdose insulin, pretreatment with catalase significantly restored the cellular GJIC function, decreased the phosphorylation level of Cx43 at s368, and enhanced Cx43 expression. In conclusion, these data indicate that highdose insulin inhibits cellular GJIC function through the oxidative stressactivated signaling pathway. This phenomenon may also constitute a potential mechanism underlying the pathogenesis of insulin resistance and its complications.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	1
Volume Number	12
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-07-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Cell Communication Drug Effects Gap Junctions Metabolism Insulin Pharmacology Muscle, Smooth, Vascular Animals Cells, Cultured Connexin 43 Fluorescence Recovery After Photobleaching Pathology Glucose Hydrogen Peroxide Hypoglycemic Agents Immunohistochemistry Cytology Phosphorylation Rats, Sprague-dawley Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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