NDLI: Dynamic expression of miR-206-3p during mouse skin development is independent of keratinocyte differentiation.

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Dynamic expression of miR-206-3p during mouse skin development is independent of keratinocyte differentiation.

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Dynamic expression of miR-206-3p during mouse skin development is independent of keratinocyte differentiation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mu, Yuan Zhou, Hong Chen, Hong-Bing Wu, Wei-Jiang Hu, Li-Chao
Description	Author Affiliation: Mu Y ( Department of Clinical Laboratory, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.); Zhou H ( Department of Clinical Laboratory and Hematology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.); Wu WJ ( Department of Histology and Embryology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.); Hu LC ( Department of Clinical Laboratory and Hematology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.); Chen HB ( Department of Clinical Laboratory, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.)
Abstract	MicroRNA-206 (miR-206), the homolog of which in mice is termed miR-206-3p, is a muscle-specific miRNA known to be important in the development of skeletal muscle, and is involved in smooth muscle innervation of the airway through the posttranscriptional suppression of brainderived neurotrophic factor (Bdnf). miR2063p is also expressed at significant levels in adult and embryonic skin; however, its functional roles in adult skin and during skin development remain to be fully elucidated. In the present study, the spatiotemporal expression of miR2063p and its targetgene, Bdnf, during mouse skin development were investigated. The expression level of miR2063p increased from 13.5 days postcoitus (dpc), peaked at 17.5 dpc and declined following birth. The observed temporal profile of the expression of miR2063p was accompanied by an inverse change in the protein expression levels of BDNF. However, the mRNA expression levels of Bdnf did not parallel those of BDNF protein. The localization of the expression of miR2063p was similar, or located near that of ubiquitin carboxylterminal hydrolase L1 during skin development. An in vitro keratinocyte model demonstrated no significant differences between primary and differentiated keratinocytes in the expression levels of either miR2063p (P=0.227) or Bdnf (mRNA, P=0.118; mature BDNF, P=0.106; proBDNF, P=0.905). These findings indicate a potential role for miR2063p in cutaneous innervation, which largely relies on BDNF neurotrophic support and is independent of keratinocyte differentiation. The results of the present study suggested that this novel mechanism may be targeted for developing potential therapeutic approaches.
ISSN	17912997
e-ISSN	17913004
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	12
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-12-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Micrornas Metabolism Skin Animals Brain-derived Neurotrophic Factor Genetics Cell Differentiation Cells, Cultured Keratinocytes Cytology Mice Mice, Inbred Balb C Protein Precursors Real-time Polymerase Chain Reaction Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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