NDLI: Involvement of epithelial-to-mesenchymal transition and associated transforming growth factor-ß/Smad signaling in paraquat-induced pulmonary fibrosis.

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Involvement of epithelial-to-mesenchymal transition and associated transforming growth factor-ß/Smad signaling in paraquat-induced pulmonary fibrosis.

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Involvement of epithelial-to-mesenchymal transition and associated transforming growth factor-ß/Smad signaling in paraquat-induced pulmonary fibrosis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chang, Wen-Xiu Han, Ying-Ying Shen, Peng
Description	Author Affiliation: Han YY ( Department of Nephrology, Tianjin First Center Hospital, Tianjin 300192, P.R. China.); Shen P ( Department of Emergency Medicine, Tianjin First Center Hospital, Tianjin 300192, P.R. China.); Chang WX ( Department of Nephrology, Tianjin First Center Hospital, Tianjin 300192, P.R. China.)
Abstract	Paraquat (PQ) is a highly toxic herbicide which is able to induce pulmonary fibrosis in humans and animals. The epithelialtomesenchymal transition (EMT) was demonstrated to be an important factor in pulmonary fibrosis. However, it has remained elusive whether PQ induces pulmonary fibrosis via EMT, which was therefore investigated in the present study. In addition, the underlying mechanisms of PQinduced EMT were examined in vitro. Hematoxylin and eosin staining of rat lung tissues demonstrated that PQ induced pulmonary fibrosis in vivo. Western blot analysis then revealed that the expression of epithelial cell marker Ecadherin was significantly decreased, while the expression of mesenchymal markers smoothmuscle actin and vimentin was significantly increased in rat lung tissues and A549 cells following PQ treatment. Transforming growth factor (TGF)ß/Smad signaling was also induced by PQ as evidenced by increased expression of TGFß1 and Smad2. However, PQinduced EMT in A549 cells was abolished by transfection with TGFß1specific small hairpin RNA. In conclusion, the present study demonstrated that PQ induced EMT in vivo and in vitro, which may be an important process in the development of PQinduced pulmonary fibrosis. In addition, TGF-ß/Smad signaling was involved in PQ-induced EMT.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2015.4454
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	12
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-12-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Epithelial-mesenchymal Transition Physiology Paraquat Pulmonary Fibrosis Chemically Induced Signal Transduction Smad2 Protein Metabolism Transforming Growth Factor Beta1 Actins Animals Cadherins Cell Line, Tumor Disease Models, Animal Drug Effects Herbicides Toxicity Physiopathology Rna Interference Rna, Small Interfering Rats, Sprague-dawley Antagonists & Inhibitors Genetics Vimentin Research Support, Non-u.s. Gov't Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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