NDLI: Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway. (Journal: Molecular Medicine Reports Volume: 12 Issue: 6)

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Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway. (Journal: Molecular Medicine Reports Volume: 12 Issue: 6)

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhao, Wei Zhang, Qiwen Lu, Mingshu
Description	Author Affiliation: Zhao W ( Department of General Surgery, People's Hospital of Laiwu, Laiwu, Shandong 271100, P.R. China.); Lu M ( Department of General Surgery, People's Hospital of Laiwu, Laiwu, Shandong 271100, P.R. China.); Zhang Q ( Department of General Surgery, People's Hospital of Laiwu, Laiwu, Shandong 271100, P.R. China.)
Abstract	Chloride intracellular channel 1 (CLIC1) has been demonstrated to be overexpressed in gastric cancer, and elevated CLIC1 expression levels are markedly associated with the processes of tumor cell migration and invasion. However, the regulatory mechanism and signaling pathway underlying these processes have remained to be elucidated. The present study examined the impact of N-acetyl cysteine (NAC), indanyloxyacetic acid (IAA)-94 and SB203580, inhibitors of reactive oxygen species (ROS), as well as CLIC1 and p38 mitogen-activated protein kinase (MAPK) on the migration and invasion of SGC-7901 gastric cancer cells in a hypoxiareoxygenation (H-R) microenvironment. The results demonstrated that intracellular ROS and CLIC1 levels were increased under HR conditions, and that functional inhibition of CLIC1 significantly decreased the HRelevated ROS generation and pp38 MAPK levels in SGC7901 cells, as well as inhibited the migration and invasion of SGC7901 cells. In addition, the expression levels of MMP2 and MMP9 were inhibited by NAC, IAA94 and SB203580. These results indicated that CLIC1 regulates gastric cancer-cell migration and invasion via the ROS-mediated p38 MAPK signaling pathway.
ISSN	17912997
e-ISSN	17913004
DOI	10.3892/mmr.2015.4459
Journal	Molecular Medicine Reports
Issue Number	6
Volume Number	12
Language	English
Publisher	Spandidos Publications
Publisher Date	2015-12-01
Publisher Place	Greece
Access Restriction	Open
Subject Keyword	Chloride Channels Metabolism P38 Mitogen-activated Protein Kinases Acetylcysteine Pharmacology Cell Line, Tumor Cell Movement Drug Effects Antagonists & Inhibitors Down-regulation Glycolates Imidazoles Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Pyridines Reactive Oxygen Species Signal Transduction Stomach Neoplasms Pathology Discipline Molecular Biology
Content Type	Text
Resource Type	Article
Subject	Genetics Biochemistry Molecular Biology Cancer Research Molecular Medicine Oncology

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